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PRJNA207719: Tissue specific transcriptome profiling
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Results for bach1a+bach1b+bach2a+bach2b
Z-value: 1.34
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Transcription factors associated with bach1a+bach1b+bach2a+bach2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000002196 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 b | |
| ENSDARG00000004074 | BTB and CNC homology 1, basic leucine zipper transcription factor 2b | |
| ENSDARG00000036569 | BTB and CNC homology 1, basic leucine zipper transcription factor 2a | |
| ENSDARG00000062553 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 a |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| bach2a | dr11_v1_chr17_+_15674052_15674052 | 0.95 | 1.4e-02 | Click! |
| bach2b | dr11_v1_chr20_-_24022558_24022558 | 0.84 | 7.6e-02 | Click! |
| bach1a | dr11_v1_chr15_-_8191992_8191992 | 0.76 | 1.4e-01 | Click! |
| bach1b | dr11_v1_chr10_+_25369254_25369254 | -0.58 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of bach1a+bach1b+bach2a+bach2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:1903670 | regulation of sprouting angiogenesis(GO:1903670) |
| 0.0 | 3.4 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 3.0 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 2.6 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.5 | 2.0 | GO:0090387 | phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387) |
| 0.6 | 1.7 | GO:0015824 | proline transport(GO:0015824) |
| 0.2 | 1.7 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.0 | 1.6 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.0 | 1.4 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.1 | 1.3 | GO:0021772 | olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 2.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 1.4 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 1.2 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 1.1 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.0 | 1.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.8 | GO:0032589 | neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590) |
| 0.0 | 0.7 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 2.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 1.8 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 1.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 1.3 | GO:0031843 | neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843) |
| 0.0 | 1.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.1 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
| 0.0 | 1.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 1.0 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 1.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 1.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.2 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 0.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 0.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |