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PRJNA207719: Tissue specific transcriptome profiling
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Results for atf5a+atf5b
Z-value: 1.67
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Transcription factors associated with atf5a+atf5b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf5b | dr11_v1_chr15_-_17869115_17869115 | 0.85 | 7.0e-02 | Click! |
| atf5a | dr11_v1_chr5_-_30418636_30418636 | 0.54 | 3.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf5a+atf5b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.1 | 2.5 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 1.9 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 1.6 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 0.0 | 1.6 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.1 | 1.5 | GO:0097105 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 0.0 | 1.5 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 1.4 | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947) |
| 0.4 | 1.3 | GO:0060845 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.2 | 1.2 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 0.8 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.7 | GO:0031514 | motile cilium(GO:0031514) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.2 | 2.3 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.4 | 1.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 1.9 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.1 | 1.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 1.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 1.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 1.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.2 | 1.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.2 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 1.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.9 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 0.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.5 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.0 | 0.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.4 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |