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PRJNA207719: Tissue specific transcriptome profiling

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Results for atf4a+atf4b

Z-value: 1.10

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Transcription factors associated with atf4a+atf4b

Gene Symbol Gene ID Gene Info
atf4b
ENSDARG00000038141 activating transcription factor 4b
atf4a
ENSDARG00000111939 activating transcription factor 4a
atf4b
ENSDARG00000114163 activating transcription factor 4b
atf4b
ENSDARG00000114542 activating transcription factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf4bdr11_v1_chr3_+_24197934_241979340.652.3e-01Click!
atf4adr11_v1_chr6_+_269204_269204-0.454.4e-01Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_31119548 1.52 ENSDART00000136578
syn1
synapsin I
chr16_+_34523515 1.28 ENSDART00000041007
stmn1b
stathmin 1b
chr12_+_46960579 1.27 ENSDART00000149032
oat
ornithine aminotransferase
chr19_-_9712530 1.13 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr18_-_16179129 1.02 ENSDART00000125353
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr15_+_29085955 1.01 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr21_-_43949208 1.00 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr23_-_27345425 0.94 ENSDART00000022042
ENSDART00000191870
scn8aa
sodium channel, voltage gated, type VIII, alpha subunit a
chr6_+_41255485 0.91 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr15_-_24869826 0.91 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr4_+_8797197 0.91 ENSDART00000158671
sult4a1
sulfotransferase family 4A, member 1
chr6_-_11780070 0.88 ENSDART00000151195
march7
membrane-associated ring finger (C3HC4) 7
chr13_-_24447332 0.88 ENSDART00000043004
slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_+_45994123 0.87 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr4_+_17279966 0.83 ENSDART00000067005
ENSDART00000137487
bcat1
branched chain amino-acid transaminase 1, cytosolic
chr3_+_31933893 0.82 ENSDART00000146509
ENSDART00000139644
lin7b
lin-7 homolog B (C. elegans)
chr2_-_36932253 0.81 ENSDART00000124217
map1sb
microtubule-associated protein 1Sb
chr4_+_1600034 0.76 ENSDART00000146779
slc38a2
solute carrier family 38, member 2
chr21_+_30502002 0.76 ENSDART00000043727
slc7a3a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr25_+_7784582 0.76 ENSDART00000155016
dgkzb
diacylglycerol kinase, zeta b
chr7_-_52842605 0.75 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr4_+_12113105 0.74 ENSDART00000182399
tmem178b
transmembrane protein 178B
chr14_+_28438947 0.72 ENSDART00000006489
acsl4a
acyl-CoA synthetase long chain family member 4a
chr5_-_55395964 0.71 ENSDART00000145791
prune2
prune homolog 2 (Drosophila)
chr20_+_28266892 0.71 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr23_-_12014931 0.71 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr5_-_57528943 0.69 ENSDART00000130320
pisd
phosphatidylserine decarboxylase
chr17_-_45552602 0.67 ENSDART00000154844
ENSDART00000034432
susd4
sushi domain containing 4
chr12_+_34953038 0.67 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr12_-_32066469 0.61 ENSDART00000140685
ENSDART00000062185
rab40b
RAB40B, member RAS oncogene family
chr20_-_29418620 0.59 ENSDART00000172634
ryr3
ryanodine receptor 3
chr9_-_9228941 0.56 ENSDART00000121665
cbsb
cystathionine-beta-synthase b
chr5_-_32323136 0.53 ENSDART00000110804
hspb15
heat shock protein, alpha-crystallin-related, b15
chr5_+_3501859 0.53 ENSDART00000080486
ywhag1
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr5_-_55395384 0.53 ENSDART00000147298
ENSDART00000082577
prune2
prune homolog 2 (Drosophila)
chr10_-_31104983 0.52 ENSDART00000186941
pknox2
pbx/knotted 1 homeobox 2
chr15_-_25392589 0.52 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr3_+_40856095 0.51 ENSDART00000143207
mmd2a
monocyte to macrophage differentiation-associated 2a
chr2_+_35240764 0.51 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr2_-_37059966 0.51 ENSDART00000137967
diras1b
DIRAS family, GTP-binding RAS-like 1b
chr7_+_33314925 0.50 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr12_-_35386910 0.50 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr24_-_39771667 0.47 ENSDART00000181867
GFOD1
si:ch211-276f18.2
chr23_-_18030399 0.47 ENSDART00000136967
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr6_+_37754763 0.46 ENSDART00000110770
herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr2_+_1001560 0.45 ENSDART00000134656
cacna1eb
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr8_+_54202554 0.43 ENSDART00000020569
creld1b
cysteine-rich with EGF-like domains 1b
chr9_+_2574122 0.42 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr17_+_12700617 0.41 ENSDART00000191931
stmn4l
stathmin-like 4, like
chr8_+_42917515 0.41 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr18_-_2727764 0.38 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr5_-_57652168 0.37 ENSDART00000166245
gb:eh456644
expressed sequence EH456644
chr16_-_20006270 0.36 ENSDART00000079155
hdac9b
histone deacetylase 9b
chr12_-_46959990 0.35 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr14_-_30945515 0.35 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr19_+_30885258 0.35 ENSDART00000143394
yars
tyrosyl-tRNA synthetase
chr14_-_7306983 0.34 ENSDART00000158914
si:ch211-51f19.1
si:ch211-51f19.1
chr20_-_18915376 0.33 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr5_-_41494831 0.33 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr20_+_16743056 0.32 ENSDART00000050308
calm1b
calmodulin 1b
chr3_-_15889508 0.30 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr6_+_23809501 0.28 ENSDART00000168701
glulb
glutamate-ammonia ligase (glutamine synthase) b
chr5_+_13243446 0.28 ENSDART00000186140
CR933528.1

chr3_+_25907266 0.28 ENSDART00000170324
ENSDART00000192633
tom1
target of myb1 membrane trafficking protein
chr2_+_7849890 0.27 ENSDART00000114241
si:ch211-38m6.6
si:ch211-38m6.6
chr20_-_20610812 0.27 ENSDART00000181870
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr6_+_49551614 0.26 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr24_+_18948665 0.25 ENSDART00000106186
prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_-_43935119 0.25 ENSDART00000142271
si:ch211-204c21.1
si:ch211-204c21.1
chr12_+_41697664 0.24 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr18_+_17493859 0.24 ENSDART00000090754
si:dkey-102f14.5
si:dkey-102f14.5
chr25_+_28893615 0.23 ENSDART00000156994
ENSDART00000075151
amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr21_-_36948 0.23 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr20_-_20611063 0.23 ENSDART00000063492
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr7_-_35036770 0.22 ENSDART00000123174
galr1b
galanin receptor 1b
chr12_-_48374728 0.22 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr16_-_36093776 0.21 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr25_+_26923193 0.21 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr17_+_8175998 0.21 ENSDART00000131200
myct1b
myc target 1b
chr1_-_19237576 0.21 ENSDART00000143663
ENSDART00000131579
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr5_-_43935460 0.20 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
si:ch211-204c21.1
chr15_+_20543770 0.20 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr25_-_6389713 0.20 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa
chr9_+_747612 0.19 ENSDART00000181004
insig2
insulin induced gene 2
chr20_-_14680897 0.19 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr15_-_23908779 0.19 ENSDART00000088808
usp32
ubiquitin specific peptidase 32
chr13_-_25548733 0.19 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr14_-_47882706 0.18 ENSDART00000188772
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr6_-_31233696 0.17 ENSDART00000079173
lepr
leptin receptor
chr22_+_38276024 0.17 ENSDART00000143792
rcor3
REST corepressor 3
chr15_-_24960730 0.17 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr16_+_40024883 0.17 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr18_-_21047007 0.15 ENSDART00000162702
igf1ra
insulin-like growth factor 1a receptor
chr18_+_27926839 0.15 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr2_-_32486080 0.15 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr13_+_4225173 0.15 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr10_+_10210455 0.15 ENSDART00000144214
sh2d3ca
SH2 domain containing 3Ca
chr24_+_32525146 0.15 ENSDART00000132417
ENSDART00000110185
yme1l1a
YME1-like 1a
chr7_+_39664055 0.14 ENSDART00000146171
zgc:158564
zgc:158564
chr15_-_23908605 0.14 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr20_+_21583639 0.14 ENSDART00000131069
esr2a
estrogen receptor 2a
chr16_+_4839078 0.14 ENSDART00000150111
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr15_-_33495048 0.14 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr8_+_7778770 0.13 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr1_-_11519934 0.13 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr8_-_31384607 0.13 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr13_+_22317216 0.13 ENSDART00000110794
usp54a
ubiquitin specific peptidase 54a
chr2_-_58257624 0.12 ENSDART00000098940
foxl2b
forkhead box L2b
chr25_-_21894317 0.11 ENSDART00000089642
fbxo31
F-box protein 31
chr3_-_12930217 0.10 ENSDART00000166322
pdgfab
platelet-derived growth factor alpha polypeptide b
chr16_+_4838808 0.10 ENSDART00000179363
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr19_-_8812891 0.10 ENSDART00000151134
ENSDART00000025385
ENSDART00000180291
cers2a
ceramide synthase 2a
chr23_+_16760845 0.10 ENSDART00000185952
ENSDART00000147724
si:rp71-1k13.6
si:rp71-1k13.6
chr7_-_30272871 0.10 ENSDART00000099586
zgc:162945
zgc:162945
chr15_+_24737599 0.09 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr2_+_44348473 0.08 ENSDART00000155166
ENSDART00000098146
zgc:152670
zgc:152670
chr17_-_50220228 0.08 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr2_+_16597011 0.08 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr15_-_17870090 0.08 ENSDART00000155066
atf5b
activating transcription factor 5b
chr1_+_37312580 0.08 ENSDART00000171340
fam193a
family with sequence similarity 193, member A
chr24_-_38644937 0.07 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr20_-_19532531 0.07 ENSDART00000125830
ENSDART00000179566
ENSDART00000184193
eif2b4
BX276101.2
eukaryotic translation initiation factor 2B, subunit 4 delta

chr7_-_31830936 0.06 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr4_-_17642168 0.06 ENSDART00000007030
klhl42
kelch-like family, member 42
chr12_-_13205572 0.04 ENSDART00000152670
pelo
pelota mRNA surveillance and ribosome rescue factor
chr17_-_42799104 0.04 ENSDART00000154755
prkd3
protein kinase D3
chr5_-_69499486 0.04 ENSDART00000023983
ENSDART00000180293
psat1
phosphoserine aminotransferase 1
chr14_+_7892021 0.03 ENSDART00000161307
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr22_+_25931782 0.03 ENSDART00000157842
dnaja3b
DnaJ (Hsp40) homolog, subfamily A, member 3B
chr20_-_32007209 0.03 ENSDART00000021575
adgb
androglobin
chr24_-_37484123 0.02 ENSDART00000111623
cluap1
clusterin associated protein 1
chr6_+_10871659 0.02 ENSDART00000041858
mtx2
metaxin 2
chr12_+_13205955 0.02 ENSDART00000092906
ppp1cab
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr12_-_13205854 0.02 ENSDART00000077829
pelo
pelota mRNA surveillance and ribosome rescue factor
chr14_-_26465729 0.02 ENSDART00000143454
syvn1
synovial apoptosis inhibitor 1, synoviolin
chr16_-_42770064 0.02 ENSDART00000112879
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr20_-_35246150 0.02 ENSDART00000090549
fzd3a
frizzled class receptor 3a
chr3_+_33440615 0.02 ENSDART00000146005
gtpbp1
GTP binding protein 1
chr3_-_40284744 0.02 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr22_-_20720427 0.01 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr12_+_17603528 0.01 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr6_+_48862 0.01 ENSDART00000082954
mbd5
methyl-CpG binding domain protein 5
chr14_-_23801389 0.01 ENSDART00000054264
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr13_-_9300299 0.01 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr23_-_36441693 0.01 ENSDART00000024354
csad
cysteine sulfinic acid decarboxylase
chr13_-_25408387 0.01 ENSDART00000002741
itprip
inositol 1,4,5-trisphosphate receptor interacting protein
chr19_+_30884706 0.00 ENSDART00000052126
yars
tyrosyl-tRNA synthetase
chr19_+_30884960 0.00 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
yars
tyrosyl-tRNA synthetase
chr16_-_31351419 0.00 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2 0.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957) regulation of protein activation cascade(GO:2000257)
0.2 0.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.6 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.2 0.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.4 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.8 GO:0090467 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 0.7 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.1 0.5 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.1 1.2 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 1.3 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.5 GO:0061551 trigeminal ganglion development(GO:0061551)
0.1 0.8 GO:0006868 glutamine transport(GO:0006868)
0.1 0.9 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 3.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.2 GO:0036316 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.3 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.9 GO:0051923 sulfation(GO:0051923)
0.0 0.3 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.2 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 1.5 GO:0003146 heart jogging(GO:0003146)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.5 GO:0019835 cytolysis(GO:0019835)
0.0 0.7 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.6 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.5 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 1.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.9 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.2 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.6 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 1.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 0.8 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.4 GO:0004427 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.1 0.7 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.8 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.2 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 0.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:1903924 estradiol binding(GO:1903924)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 1.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 0.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation