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PRJNA207719: Tissue specific transcriptome profiling
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Results for atf3+jdp2b
Z-value: 1.69
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Transcription factors associated with atf3+jdp2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf3 | dr11_v1_chr20_+_37794633_37794633 | 0.80 | 1.0e-01 | Click! |
| jdp2b | dr11_v1_chr20_+_46586678_46586692 | 0.15 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_59252701 Show fit | 1.54 |
ENSDART00000144829
|
uroplakin 3b |
|
| chr6_+_112579 Show fit | 1.44 |
ENSDART00000034505
|
adaptor-related protein complex 1, mu 2 subunit |
|
| chr19_-_3781405 Show fit | 1.13 |
ENSDART00000170609
|
bloodthirsty-related gene family, member 19 |
|
| chr10_+_20256454 Show fit | 1.10 |
ENSDART00000111097
|
transcriptional and immune response regulator |
|
| chr1_-_59104145 Show fit | 1.08 |
ENSDART00000132495
ENSDART00000152457 |
si:zfos-2330d3.1 si:zfos-2330d3.7 |
|
| chr7_-_20241346 Show fit | 0.99 |
ENSDART00000173619
ENSDART00000127699 |
si:ch73-335l21.4 |
|
| chr5_-_29531948 Show fit | 0.97 |
ENSDART00000098360
|
arrestin domain containing 1a |
|
| chr5_+_29831235 Show fit | 0.96 |
ENSDART00000109660
|
F11 receptor, tandem duplicate 1 |
|
| chr22_+_1170294 Show fit | 0.95 |
ENSDART00000159761
ENSDART00000169809 |
interferon regulatory factor 6 |
|
| chr17_-_2039511 Show fit | 0.93 |
ENSDART00000160223
|
serine peptidase inhibitor, Kunitz type 1 a |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf3+jdp2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 1.5 | GO:0072028 | nephron morphogenesis(GO:0072028) |
| 0.1 | 1.4 | GO:0090559 | regulation of membrane permeability(GO:0090559) |
| 0.0 | 1.4 | GO:0030261 | chromosome condensation(GO:0030261) |
| 0.0 | 1.4 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 1.3 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.2 | 1.2 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.0 | 1.2 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.1 | 1.1 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.1 | 1.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.9 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 1.5 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.0 | 1.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 1.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.6 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 1.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 1.2 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 1.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.0 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 0.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 0.9 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |