ISMARA results: atf2+atf7a+atf7b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 2.65

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Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Gene Symbol	Gene ID	Gene Info
atf7a NCBI UniProt	ENSDARG00000011298	activating transcription factor 7a
atf2 NCBI UniProt	ENSDARG00000023903	activating transcription factor 2
atf7b NCBI UniProt	ENSDARG00000055481	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000114492	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000115171	activating transcription factor 7b
creb5b NCBI UniProt	ENSDARG00000070536	cAMP responsive element binding protein 5b
creb5a NCBI UniProt	ENSDARG00000099002	cAMP responsive element binding protein 5a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf2	dr11_v1_chr9_+_2343096_2343172	0.95	1.3e-02	Click!
atf7b	dr11_v1_chr6_-_39631164_39631181	0.85	6.8e-02	Click!
creb5b	dr11_v1_chr16_-_20707742_20707742	0.74	1.5e-01	Click!
creb5a	dr11_v1_chr19_-_19505167_19505167	0.55	3.3e-01	Click!
atf7a	dr11_v1_chr23_-_27479558_27479558	0.19	7.6e-01	Click!

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_-_43606502 Show fit	4.50	ENSDART00000151030	si:ch73-362m14.4 NCBI UniProt Show fit	si:ch73-362m14.4
chr3_-_49566364 Show fit	3.83	ENSDART00000161507	zgc:153426 NCBI UniProt Show fit	zgc:153426
chr9_+_7548533 Show fit	3.55	ENSDART00000081543	ptprna NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, Na
chr24_-_7632187 Show fit	3.50	ENSDART00000041714	atp6v0a1b NCBI UniProt Show fit	ATPase H+ transporting V0 subunit a1b
chr16_+_34523515 Show fit	3.42	ENSDART00000041007	stmn1b NCBI UniProt Show fit	stathmin 1b
chr6_+_13920479 Show fit	3.32	ENSDART00000155480	ptprnb NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, Nb
chr8_+_44714336 Show fit	3.11	ENSDART00000145801	elmod3 NCBI UniProt Show fit	ELMO/CED-12 domain containing 3
chr1_-_22861348 Show fit	2.82	ENSDART00000139412	SMIM18 NCBI UniProt Show fit	si:dkey-92j12.6
chr9_-_296169 Show fit	2.80	ENSDART00000165228	kif5aa NCBI UniProt Show fit	kinesin family member 5A, a
chr19_-_1961024 Show fit	2.71	ENSDART00000108784	mturn NCBI UniProt Show fit	maturin, neural progenitor differentiation regulator homolog (Xenopus)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.2	GO:0006470	protein dephosphorylation(GO:0006470)
0.1	5.1	GO:0007019	microtubule depolymerization(GO:0007019)
0.3	4.5	GO:0051127	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	4.5	GO:0000226	microtubule cytoskeleton organization(GO:0000226)
0.0	4.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3	3.8	GO:0032481	positive regulation of type I interferon production(GO:0032481)
0.0	3.7	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.9	3.6	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	3.2	GO:0006821	chloride transport(GO:0006821)
0.7	2.8	GO:1990535	neuron projection maintenance(GO:1990535)

Showing 1 to 10 of 118 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.2	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	8.9	GO:0043005	neuron projection(GO:0043005)
0.1	7.9	GO:0030141	secretory granule(GO:0030141)
0.1	6.9	GO:0005871	kinesin complex(GO:0005871)
0.3	4.5	GO:0031209	SCAR complex(GO:0031209)
0.0	3.9	GO:0008021	synaptic vesicle(GO:0008021)
0.0	3.0	GO:0031902	late endosome membrane(GO:0031902)
0.0	2.5	GO:0000922	spindle pole(GO:0000922)
0.2	2.4	GO:0044295	axonal growth cone(GO:0044295)
0.0	2.4	GO:0005802	trans-Golgi network(GO:0005802)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.6	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.5	4.5	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	4.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	4.1	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	3.9	GO:0005096	GTPase activator activity(GO:0005096)
0.1	3.7	GO:0042577	lipid phosphatase activity(GO:0042577)
0.2	3.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.1	2.8	GO:0030165	PDZ domain binding(GO:0030165)
0.2	2.3	GO:0051117	ATPase binding(GO:0051117)
0.3	2.2	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	1.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	1.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	1.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	1.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	0.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.6	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	1.7	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.2	1.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	1.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	1.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.0	1.1	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	0.9	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	0.9	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 20 entries

Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 2.65

Motif logo

Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Activity-expression correlation:

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: