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PRJNA207719: Tissue specific transcriptome profiling
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Results for arnt
Z-value: 1.30
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Transcription factors associated with arnt
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| arnt | dr11_v1_chr16_-_4610255_4610278 | 0.63 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_50770537 Show fit | 1.52 |
ENSDART00000158723
|
synuclein, beta |
|
| chr2_+_18988407 Show fit | 1.21 |
ENSDART00000170216
|
glutamate-ammonia ligase (glutamine synthase) a |
|
| chr1_-_39943596 Show fit | 1.18 |
ENSDART00000149730
|
storkhead box 2a |
|
| chr3_-_59472422 Show fit | 1.12 |
ENSDART00000100327
|
neuronal pentraxin 1 like |
|
| chr14_+_35748385 Show fit | 1.10 |
ENSDART00000064617
ENSDART00000074671 ENSDART00000172803 |
glutamate receptor, ionotropic, AMPA 2b |
|
| chr14_+_35748206 Show fit | 1.08 |
ENSDART00000177391
|
glutamate receptor, ionotropic, AMPA 2b |
|
| chr21_-_39639954 Show fit | 1.04 |
ENSDART00000026766
|
aldolase C, fructose-bisphosphate, b |
|
| chr7_+_22823889 Show fit | 1.03 |
ENSDART00000127467
ENSDART00000148576 ENSDART00000149993 |
phosphorylase, glycogen, muscle b |
|
| chr8_+_40081403 Show fit | 0.98 |
ENSDART00000138036
|
leucine rich repeat containing 75Ba |
|
| chr11_-_39044595 Show fit | 0.94 |
ENSDART00000065461
|
claudin 19 |
Network of associatons between targets according to the STRING database.
First level regulatory network of arnt
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 1.5 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 1.2 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.0 | 1.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.3 | 1.0 | GO:0052576 | carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576) |
| 0.0 | 1.0 | GO:0008593 | regulation of Notch signaling pathway(GO:0008593) |
| 0.2 | 0.9 | GO:1900271 | regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271) |
| 0.2 | 0.9 | GO:0071881 | adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881) |
| 0.0 | 0.9 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.2 | 0.7 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 2.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 0.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.8 | GO:0038201 | TOR complex(GO:0038201) |
| 0.0 | 0.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 0.7 | GO:0097648 | G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648) |
| 0.0 | 0.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.6 | GO:0016586 | RSC complex(GO:0016586) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.5 | 1.5 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.2 | 1.2 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.2 | 1.0 | GO:0008184 | phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 1.0 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 0.9 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.0 | 0.9 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.2 | 0.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 0.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.8 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 0.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.5 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.5 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |