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PRJNA207719: Tissue specific transcriptome profiling
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Results for alx4a+alx4b
Z-value: 0.65
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Transcription factors associated with alx4a+alx4b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| alx4b | dr11_v1_chr18_+_38321039_38321039 | -0.39 | 5.2e-01 | Click! |
| alx4a | dr11_v1_chr7_-_26924903_26924903 | 0.32 | 6.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_9669717 Show fit | 0.73 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr17_-_12336987 Show fit | 0.68 |
ENSDART00000172001
|
synaptosomal-associated protein, 25b |
|
| chr5_-_23280098 Show fit | 0.62 |
ENSDART00000126540
ENSDART00000051533 |
proteolipid protein 1b |
|
| chr2_+_50608099 Show fit | 0.51 |
ENSDART00000185805
ENSDART00000111135 |
neuronal differentiation 6b |
|
| chr12_+_18578597 Show fit | 0.51 |
ENSDART00000134944
|
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b |
|
| chr8_+_7359294 Show fit | 0.49 |
ENSDART00000121708
|
proprotein convertase subtilisin/kexin type 1 inhibitor, like |
|
| chr23_-_3681026 Show fit | 0.48 |
ENSDART00000192128
ENSDART00000040086 |
protein kinase C and casein kinase substrate in neurons 1a |
|
| chr4_+_21129752 Show fit | 0.47 |
ENSDART00000169764
|
synaptotagmin Ia |
|
| chr2_-_38000276 Show fit | 0.46 |
ENSDART00000034790
|
Purkinje cell protein 4 like 1 |
|
| chr18_+_21408794 Show fit | 0.44 |
ENSDART00000140161
|
N-terminal EF-hand calcium binding protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of alx4a+alx4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 0.7 | GO:0099540 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.1 | 0.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.0 | 0.6 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 0.6 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 0.5 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.0 | 0.5 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
| 0.1 | 0.4 | GO:0045938 | positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0031105 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.1 | 0.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 0.5 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 0.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.1 | 0.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.3 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.8 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 0.8 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.2 | 0.7 | GO:0060175 | brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 0.6 | GO:0031843 | neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843) |
| 0.0 | 0.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.5 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
| 0.0 | 0.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.1 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.1 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |