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PRJNA207719: Tissue specific transcriptome profiling
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Results for alx1
Z-value: 1.09
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Transcription factors associated with alx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| alx1 | dr11_v1_chr18_+_16246806_16246806 | -0.12 | 8.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_31276842 Show fit | 1.80 |
ENSDART00000187238
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr15_-_21877726 Show fit | 0.76 |
ENSDART00000127819
ENSDART00000145646 ENSDART00000100897 ENSDART00000144739 |
zgc:162608 |
|
| chr20_-_40755614 Show fit | 0.65 |
ENSDART00000061247
|
connexin 32.3 |
|
| chr9_-_22821901 Show fit | 0.57 |
ENSDART00000101711
|
nebulin |
|
| chr10_+_21867307 Show fit | 0.55 |
ENSDART00000126629
|
cerebellin 17 |
|
| chr9_-_22834860 Show fit | 0.48 |
ENSDART00000146486
|
nebulin |
|
| chr7_-_38792543 Show fit | 0.46 |
ENSDART00000157416
|
si:dkey-23n7.10 |
|
| chr25_+_31267268 Show fit | 0.45 |
ENSDART00000181239
|
troponin I type 2a (skeletal, fast), tandem duplicate 3 |
|
| chr24_-_40744672 Show fit | 0.43 |
ENSDART00000160672
|
|
|
| chr25_+_31277415 Show fit | 0.43 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of alx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 1.5 | GO:0071691 | cardiac muscle thin filament assembly(GO:0071691) |
| 0.2 | 0.8 | GO:0010872 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.0 | 0.6 | GO:0051445 | regulation of meiotic cell cycle(GO:0051445) |
| 0.1 | 0.5 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.4 | GO:0043385 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
| 0.0 | 0.4 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.0 | 0.4 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.4 | GO:0021551 | central nervous system morphogenesis(GO:0021551) |
| 0.0 | 0.4 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 0.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.8 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 0.5 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.4 | GO:0071546 | pi-body(GO:0071546) |
| 0.0 | 0.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.3 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 0.5 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.4 | GO:0009374 | biotin binding(GO:0009374) |
| 0.1 | 0.4 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.0 | 0.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 0.3 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.0 | 0.3 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.0 | 0.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.3 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.0 | 0.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.3 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 0.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |