ISMARA results: VDR+nr1i2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for VDR+nr1i2_vdrb

Z-value: 0.29

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Transcription factors associated with VDR+nr1i2_vdrb

Gene Symbol	Gene ID	Gene Info
nr1i2 NCBI UniProt	ENSDARG00000029766	nuclear receptor subfamily 1, group I, member 2
VDR NCBI UniProt	ENSDARG00000112923	vitamin D receptor
vdrb NCBI UniProt	ENSDARG00000070721	vitamin D receptor b
vdrb NCBI UniProt	ENSDARG00000114864	vitamin D receptor b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
vdrb	dr11_v1_chr6_-_39005133_39005133	0.75	1.4e-01	Click!
CABZ01088036.1	dr11_v1_chr23_+_45785563_45785563	0.62	2.7e-01	Click!
nr1i2	dr11_v1_chr9_+_9502610_9502610	0.56	3.3e-01	Click!

Activity profile of VDR+nr1i2_vdrb motif

Sorted Z-values of VDR+nr1i2_vdrb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_25112269 Show fit	0.34	ENSDART00000147546	ndrg3a NCBI UniProt Show fit	ndrg family member 3a
chr11_+_25111846 Show fit	0.32	ENSDART00000128705 ENSDART00000190058	ndrg3a NCBI UniProt Show fit	ndrg family member 3a
chr14_-_33872092 Show fit	0.31	ENSDART00000111903	si:ch73-335m24.2 NCBI UniProt Show fit	si:ch73-335m24.2
chr17_-_12385308 Show fit	0.27	ENSDART00000080927	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr16_+_53685812 Show fit	0.27	ENSDART00000014098	ggctb NCBI UniProt Show fit	gamma-glutamylcyclotransferase b
chr14_-_33872616 Show fit	0.24	ENSDART00000162840	si:ch73-335m24.2 NCBI UniProt Show fit	si:ch73-335m24.2
chr9_+_38888025 Show fit	0.23	ENSDART00000148306	map2 NCBI UniProt Show fit	microtubule-associated protein 2
chr1_-_56223913 Show fit	0.22	ENSDART00000019573	zgc:65894 NCBI UniProt Show fit	zgc:65894
chr5_+_23624684 Show fit	0.20	ENSDART00000051539	cx27.5 NCBI UniProt Show fit	connexin 27.5
chr5_-_42544522 Show fit	0.18	ENSDART00000157968	BX510949.1 NCBI UniProt Show fit

Showing 1 to 10 of 194 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR+nr1i2_vdrb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Total log-likelihood	Term	Description
0.3	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	GO:0021577	hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.1	GO:0045843	negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.1	GO:0070207	protein homotrimerization(GO:0070207)
0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.0	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)

Showing 1 to 9 of 9 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.2	GO:0042584	chromaffin granule membrane(GO:0042584)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.0	0.2	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.2	GO:0072349	modified amino acid transmembrane transporter activity(GO:0072349)
0.0	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0044736	acid-sensing ion channel activity(GO:0044736)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling

Showing 1 to 1 of 1 entries

Results for VDR+nr1i2_vdrb

Z-value: 0.29

Motif logo

Transcription factors associated with VDR+nr1i2_vdrb

Activity-expression correlation:

Activity profile of VDR+nr1i2_vdrb motif

Sorted Z-values of VDR+nr1i2_vdrb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR+nr1i2_vdrb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: