ISMARA results: TCF4_id4_mespaa+mespab+mespba+mespbb

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PRJNA207719: Tissue specific transcriptome profiling

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Results for TCF4_id4_mespaa+mespab+mespba+mespbb

Z-value: 1.48

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Transcription factors associated with TCF4_id4_mespaa+mespab+mespba+mespbb

Gene Symbol	Gene ID	Gene Info
TCF4 NCBI UniProt	ENSDARG00000107408	transcription factor 4
id4 NCBI UniProt	ENSDARG00000045131	inhibitor of DNA binding 4
mespaa NCBI UniProt	ENSDARG00000017078	mesoderm posterior aa
mespba NCBI UniProt	ENSDARG00000030347	mesoderm posterior ba
mespab NCBI UniProt	ENSDARG00000068761	mesoderm posterior ab
mespbb NCBI UniProt	ENSDARG00000097947	mesoderm posterior bb
mespba NCBI UniProt	ENSDARG00000110553	mesoderm posterior ba
mespaa NCBI UniProt	ENSDARG00000114890	mesoderm posterior aa

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mespaa	dr11_v1_chr7_+_15324830_15324830	-0.82	9.0e-02	Click!
id4	dr11_v1_chr16_-_9980402_9980402	-0.70	1.9e-01	Click!
TCF4	dr11_v1_chr21_+_1381276_1381276	-0.44	4.5e-01	Click!
mespbb	dr11_v1_chr25_-_11026907_11026907	-0.42	4.8e-01	Click!

Activity profile of TCF4_id4_mespaa+mespab+mespba+mespbb motif

Sorted Z-values of TCF4_id4_mespaa+mespab+mespba+mespbb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_48312109 Show fit	1.26	ENSDART00000161103	si:ch73-359m17.9 NCBI UniProt Show fit	si:ch73-359m17.9
chr16_-_36834505 Show fit	1.07	ENSDART00000141275 ENSDART00000139588 ENSDART00000041993	pnp4b NCBI UniProt Show fit	purine nucleoside phosphorylase 4b
chr20_-_42702832 Show fit	1.01	ENSDART00000134689 ENSDART00000045816	plg NCBI UniProt Show fit	plasminogen
chr2_-_22688651 Show fit	0.77	ENSDART00000013863	agxtb NCBI UniProt Show fit	alanine-glyoxylate aminotransferase b
chr7_+_7048245 Show fit	0.77	ENSDART00000001649	actn3b NCBI UniProt Show fit	actinin alpha 3b
chr24_-_25691020 Show fit	0.69	ENSDART00000015391	chrnd NCBI UniProt Show fit	cholinergic receptor, nicotinic, delta (muscle)
chr1_+_30422143 Show fit	0.66	ENSDART00000033024	tmem41ab NCBI UniProt Show fit	transmembrane protein 41ab
chr7_+_39446247 Show fit	0.64	ENSDART00000033610 ENSDART00000099015	tnnt3b NCBI UniProt Show fit	troponin T type 3b (skeletal, fast)
chr9_+_310331 Show fit	0.64	ENSDART00000172446 ENSDART00000187731 ENSDART00000193970	stac3 NCBI UniProt Show fit	SH3 and cysteine rich domain 3
chr25_-_4146947 Show fit	0.61	ENSDART00000129268	fads2 NCBI UniProt Show fit	fatty acid desaturase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF4_id4_mespaa+mespab+mespba+mespbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0035036	binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2	1.2	GO:1901387	positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.3	1.0	GO:0042730	fibrinolysis(GO:0042730)
0.0	1.0	GO:0035383	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.2	0.9	GO:0006545	glycine biosynthetic process(GO:0006545)
0.1	0.9	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.3	0.8	GO:1990575	mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0	0.8	GO:0006942	regulation of striated muscle contraction(GO:0006942)
0.1	0.7	GO:0060832	oocyte animal/vegetal axis specification(GO:0060832)
0.1	0.7	GO:0040016	embryonic cleavage(GO:0040016)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	1.3	GO:0030315	T-tubule(GO:0030315)
0.1	1.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	1.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.9	GO:0005871	kinesin complex(GO:0005871)
0.0	0.9	GO:0005581	collagen trimer(GO:0005581)
0.0	0.8	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.7	GO:0032019	mitochondrial cloud(GO:0032019)
0.0	0.7	GO:0042555	MCM complex(GO:0042555)
0.0	0.7	GO:0032588	trans-Golgi network membrane(GO:0032588)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	GO:0035804	structural constituent of egg coat(GO:0035804)
0.1	1.3	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	1.2	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.1	1.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.1	1.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	0.9	GO:0005113	patched binding(GO:0005113)
0.1	0.8	GO:0032190	acrosin binding(GO:0032190)
0.1	0.8	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.8	GO:0008483	transaminase activity(GO:0008483)
0.0	0.7	GO:0098631	protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)

Showing 1 to 10 of 115 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.6	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.6	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.5	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.4	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	1.0	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	0.6	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.6	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.6	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.5	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	0.4	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.1	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.3	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex

Showing 1 to 10 of 24 entries

Results for TCF4_id4_mespaa+mespab+mespba+mespbb

Z-value: 1.48

Motif logo

Transcription factors associated with TCF4_id4_mespaa+mespab+mespba+mespbb

Activity-expression correlation:

Activity profile of TCF4_id4_mespaa+mespab+mespba+mespbb motif

Sorted Z-values of TCF4_id4_mespaa+mespab+mespba+mespbb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF4_id4_mespaa+mespab+mespba+mespbb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: