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PRJNA207719: Tissue specific transcriptome profiling
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Results for CT027745.1+tbx19
Z-value: 0.80
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Transcription factors associated with CT027745.1+tbx19
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbx19 | dr11_v1_chr6_+_9204099_9204099 | -0.86 | 6.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_35020529 Show fit | 0.94 |
ENSDART00000158016
|
filamin C, gamma a (actin binding protein 280) |
|
| chr3_-_55104310 Show fit | 0.83 |
ENSDART00000101713
|
hemoglobin, beta adult 1 |
|
| chr3_+_55105066 Show fit | 0.82 |
ENSDART00000110848
|
si:ch211-5k11.8 |
|
| chr23_+_32039386 Show fit | 0.63 |
ENSDART00000133801
|
myosin light chain kinase 2 |
|
| chr9_-_54304684 Show fit | 0.54 |
ENSDART00000109512
|
interleukin 13 |
|
| chr4_+_76722754 Show fit | 0.53 |
ENSDART00000153867
|
membrane-spanning 4-domains, subfamily A, member 17A.3 |
|
| chr8_+_44783424 Show fit | 0.51 |
ENSDART00000025875
|
si:ch1073-459j12.1 |
|
| chr22_+_4443689 Show fit | 0.47 |
ENSDART00000185490
|
toll-like receptor adaptor molecule 1 |
|
| chr4_+_26357221 Show fit | 0.45 |
ENSDART00000187684
ENSDART00000101545 ENSDART00000148296 ENSDART00000171433 |
troponin I, skeletal, slow d |
|
| chr3_+_32416948 Show fit | 0.44 |
ENSDART00000157324
ENSDART00000154267 ENSDART00000186094 ENSDART00000155860 ENSDART00000156986 |
proline rich Gla (G-carboxyglutamic acid) 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CT027745.1+tbx19
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 0.9 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 0.2 | 0.5 | GO:0032816 | regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) |
| 0.0 | 0.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.5 | GO:0071219 | cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222) |
| 0.0 | 0.4 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.0 | 0.4 | GO:1900077 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.0 | 0.4 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.1 | 0.3 | GO:0010269 | response to selenium ion(GO:0010269) |
| 0.0 | 0.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.8 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.1 | 0.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 0.4 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.3 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.1 | 0.2 | GO:0031085 | BLOC-3 complex(GO:0031085) |
| 0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0019825 | oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825) |
| 0.0 | 0.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.5 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 0.4 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
| 0.0 | 0.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 0.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.3 | GO:0030983 | mismatched DNA binding(GO:0030983) |
| 0.0 | 0.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 0.5 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |