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PRJNA207719: Tissue specific transcriptome profiling
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Results for CABZ01087224.1+hlfb
Z-value: 0.92
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Transcription factors associated with CABZ01087224.1+hlfb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CABZ01087224.1 | dr11_v1_chr3_+_11568523_11568523 | -0.33 | 5.9e-01 | Click! |
| hlfb | dr11_v1_chr12_+_32159272_32159272 | -0.22 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_7735157 Show fit | 0.61 |
ENSDART00000186717
|
tuftelin 1b |
|
| chr3_-_40275096 Show fit | 0.48 |
ENSDART00000141578
|
serine hydroxymethyltransferase 1 (soluble) |
|
| chr3_+_30921246 Show fit | 0.48 |
ENSDART00000076850
|
claudin i |
|
| chr22_+_11775269 Show fit | 0.47 |
ENSDART00000140272
|
keratin 96 |
|
| chr2_+_10134345 Show fit | 0.45 |
ENSDART00000100725
|
alpha-2-HS-glycoprotein 2 |
|
| chr5_+_45677781 Show fit | 0.45 |
ENSDART00000163120
ENSDART00000126537 |
group-specific component (vitamin D binding protein) |
|
| chr9_-_48736388 Show fit | 0.43 |
ENSDART00000022074
|
dehydrogenase/reductase (SDR family) member 9 |
|
| chr5_+_43782267 Show fit | 0.39 |
ENSDART00000130355
|
nitric oxide synthase 2a, inducible |
|
| chr14_+_3507326 Show fit | 0.38 |
ENSDART00000159326
|
glutathione S-transferase pi 1 |
|
| chr7_+_12950507 Show fit | 0.37 |
ENSDART00000067629
ENSDART00000158004 |
serum amyloid A |
Network of associatons between targets according to the STRING database.
First level regulatory network of CABZ01087224.1+hlfb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.0 | 0.7 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 0.2 | 0.5 | GO:0006565 | L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 0.5 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.5 | GO:0030819 | activation of adenylate cyclase activity(GO:0007190) positive regulation of cyclic nucleotide metabolic process(GO:0030801) positive regulation of cyclic nucleotide biosynthetic process(GO:0030804) positive regulation of nucleotide biosynthetic process(GO:0030810) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of cyclase activity(GO:0031281) positive regulation of adenylate cyclase activity(GO:0045762) positive regulation of lyase activity(GO:0051349) positive regulation of purine nucleotide biosynthetic process(GO:1900373) |
| 0.1 | 0.4 | GO:0031282 | regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.1 | 0.4 | GO:0051818 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883) |
| 0.0 | 0.4 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.0 | 0.4 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.0 | 0.4 | GO:0051923 | sulfation(GO:0051923) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.3 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.0 | 0.3 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.2 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.0 | 0.2 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.2 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878) |
| 0.0 | 0.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.2 | 0.5 | GO:0070905 | glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905) |
| 0.2 | 0.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 0.5 | GO:0045174 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) |
| 0.0 | 0.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 0.4 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.4 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.1 | 0.4 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.6 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.2 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.0 | 0.2 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.1 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |