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PRJNA195909:zebrafish embryo and larva development
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Results for zbtb47b+znf652
Z-value: 2.53
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Transcription factors associated with zbtb47b+znf652
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| znf652 | dr11_v1_chr3_+_15776446_15776446 | -0.96 | 5.7e-05 | Click! |
| zbtb47b | dr11_v1_chr24_-_20641000_20641000 | -0.94 | 1.4e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23913943 Show fit | 8.96 |
ENSDART00000175404
ENSDART00000129525 |
apolipoprotein A-IV b, tandem duplicate 1 |
|
| chr12_-_16764751 Show fit | 5.33 |
ENSDART00000113862
|
zgc:174154 |
|
| chr5_+_37978501 Show fit | 5.02 |
ENSDART00000012050
|
apolipoprotein A-Ia |
|
| chr10_+_44042033 Show fit | 4.36 |
ENSDART00000190006
ENSDART00000046172 |
crystallin, beta A4 |
|
| chr13_-_33822550 Show fit | 3.86 |
ENSDART00000143703
|
fibronectin leucine rich transmembrane 3 |
|
| chr13_-_18637244 Show fit | 3.63 |
ENSDART00000057869
|
methionine adenosyltransferase I, alpha |
|
| chr20_-_19365875 Show fit | 3.17 |
ENSDART00000063703
ENSDART00000187707 ENSDART00000161065 |
si:dkey-71h2.2 |
|
| chr9_-_44295071 Show fit | 3.11 |
ENSDART00000011837
|
neuronal differentiation 1 |
|
| chr3_-_50865079 Show fit | 2.82 |
ENSDART00000164295
|
peripheral myelin protein 22a |
|
| chr22_-_5682494 Show fit | 2.82 |
ENSDART00000012686
|
deoxyribonuclease 1 like 4, tandem duplicate 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb47b+znf652
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 57.8 | GO:0006355 | regulation of transcription, DNA-templated(GO:0006355) |
| 0.1 | 8.8 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 8.8 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.2 | 7.5 | GO:0042738 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 1.0 | 5.0 | GO:0010873 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.2 | 4.2 | GO:0000737 | DNA catabolic process, endonucleolytic(GO:0000737) |
| 0.2 | 4.1 | GO:0048923 | posterior lateral line neuromast hair cell differentiation(GO:0048923) |
| 0.1 | 4.1 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.1 | 4.0 | GO:0071466 | cellular response to xenobiotic stimulus(GO:0071466) |
| 0.5 | 3.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 30.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 5.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 4.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 3.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.8 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 2.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.1 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 2.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 86.5 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.1 | 9.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 7.5 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.0 | 6.3 | GO:0030414 | peptidase inhibitor activity(GO:0030414) |
| 1.0 | 5.0 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.6 | 5.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.4 | 4.2 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.1 | 4.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 4.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 3.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 1.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 1.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.9 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.5 | 5.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 3.6 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.4 | 2.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 1.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.5 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |