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PRJNA195909:zebrafish embryo and larva development
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Results for zbtb3
Z-value: 1.79
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Transcription factors associated with zbtb3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb3 | dr11_v1_chr14_+_35405518_35405518 | -0.95 | 8.3e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_52398205 Show fit | 48.12 |
ENSDART00000143225
|
si:ch211-217k17.9 |
|
| chr1_+_50921266 Show fit | 3.79 |
ENSDART00000006538
|
orthodenticle homeobox 2a |
|
| chr9_+_3429662 Show fit | 2.95 |
ENSDART00000160977
ENSDART00000114168 ENSDART00000082153 |
integrin, alpha 6a |
|
| chr3_-_61185746 Show fit | 2.84 |
ENSDART00000028219
|
parvalbumin 4 |
|
| chr7_-_35432901 Show fit | 2.80 |
ENSDART00000026712
|
matrix metallopeptidase 2 |
|
| chr7_-_25895189 Show fit | 2.74 |
ENSDART00000173599
ENSDART00000079235 ENSDART00000173786 ENSDART00000173602 ENSDART00000079245 ENSDART00000187568 ENSDART00000173505 |
CD99 molecule-like 2 |
|
| chr11_+_10548171 Show fit | 2.60 |
ENSDART00000191497
|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a |
|
| chr14_+_6546516 Show fit | 2.59 |
ENSDART00000097214
|
ADAM metallopeptidase domain 19b |
|
| chr12_+_48220584 Show fit | 2.58 |
ENSDART00000164392
|
leucine rich repeat containing 20 |
|
| chr16_+_10422836 Show fit | 2.41 |
ENSDART00000161568
|
INO80 complex subunit E |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.0 | 3.0 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.2 | 2.8 | GO:0035701 | hematopoietic stem cell migration(GO:0035701) |
| 0.1 | 2.6 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.6 | 2.4 | GO:1900619 | acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619) |
| 0.2 | 2.4 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 2.3 | GO:0055113 | epiboly involved in gastrulation with mouth forming second(GO:0055113) |
| 0.4 | 1.9 | GO:0031174 | lifelong otolith mineralization(GO:0031174) |
| 0.0 | 1.8 | GO:0070507 | regulation of microtubule cytoskeleton organization(GO:0070507) |
| 0.4 | 1.7 | GO:0021742 | abducens nucleus development(GO:0021742) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 2.8 | GO:0030017 | sarcomere(GO:0030017) |
| 0.2 | 2.4 | GO:0033202 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.1 | 2.2 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.5 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 1.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 2.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.4 | 2.4 | GO:0004104 | cholinesterase activity(GO:0004104) |
| 0.1 | 2.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 1.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 2.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 1.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 1.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.5 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 0.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |