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PRJNA195909:zebrafish embryo and larva development
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Results for zbtb14
Z-value: 2.41
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Transcription factors associated with zbtb14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb14 | dr11_v1_chr24_+_41989108_41989108 | -0.71 | 3.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_22281854 Show fit | 9.01 |
ENSDART00000146319
|
crystallin, gamma M2d3 |
|
| chr14_+_46313135 Show fit | 6.19 |
ENSDART00000172902
|
crystallin, beta A1, like 1 |
|
| chr24_+_32176155 Show fit | 4.78 |
ENSDART00000003745
|
vimentin |
|
| chr19_+_25649626 Show fit | 4.08 |
ENSDART00000146947
|
tachykinin 1 |
|
| chr2_+_42724404 Show fit | 3.22 |
ENSDART00000075392
|
brain abundant, membrane attached signal protein 1 |
|
| chr14_+_46313396 Show fit | 3.08 |
ENSDART00000047525
|
crystallin, beta A1, like 1 |
|
| chr4_+_5741733 Show fit | 2.99 |
ENSDART00000110243
|
POU class 3 homeobox 2a |
|
| chr1_-_56223913 Show fit | 2.86 |
ENSDART00000019573
|
zgc:65894 |
|
| chr23_-_20258490 Show fit | 2.80 |
ENSDART00000147326
|
laminin, beta 2 (laminin S) |
|
| chr23_+_44732863 Show fit | 2.72 |
ENSDART00000160044
ENSDART00000172268 |
ATPase Na+/K+ transporting subunit beta 2a |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 4.5 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.8 | 4.1 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.2 | 3.7 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 3.4 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.2 | 2.8 | GO:0016203 | muscle attachment(GO:0016203) |
| 0.2 | 2.7 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
| 0.1 | 2.7 | GO:0036376 | cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436) |
| 0.1 | 2.5 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.0 | 2.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 3.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 3.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 2.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 2.7 | GO:0090533 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 2.4 | GO:0005605 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
| 0.1 | 2.4 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 2.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 2.1 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 17.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 1.4 | 4.1 | GO:0031834 | neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835) |
| 0.1 | 4.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 3.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 3.1 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 2.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.4 | 2.7 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 2.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 2.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 2.8 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.0 | 2.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 1.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.5 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 1.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |