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PRJNA195909:zebrafish embryo and larva development

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Results for xbp1

Z-value: 1.49

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Transcription factors associated with xbp1

Gene Symbol Gene ID Gene Info
ENSDARG00000035622 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
xbp1dr11_v1_chr5_-_15948833_15948920-0.294.5e-01Click!

Activity profile of xbp1 motif

Sorted Z-values of xbp1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_34915886 3.49 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr12_+_10116912 2.73 ENSDART00000189630
si:dkeyp-118b1.2
chr1_-_9485939 2.41 ENSDART00000157814
mical-like 2b
chr9_+_54237100 2.37 ENSDART00000148928
RNA binding motif protein 27
chr1_-_9486214 2.27 ENSDART00000137821
mical-like 2b
chr5_+_24543862 2.09 ENSDART00000029699
ATPase H+ transporting V0 subunit a2b
chr1_-_23308225 1.96 ENSDART00000137567
ENSDART00000008201
small integral membrane protein 14
chr21_+_10701834 1.78 ENSDART00000192473
lectin, mannose-binding, 1
chr21_+_10702031 1.69 ENSDART00000102304
lectin, mannose-binding, 1
chr11_+_30647545 1.54 ENSDART00000114792
expressed sequence EH507706
chr5_-_28968964 1.53 ENSDART00000184936
ENSDART00000016628
family with sequence similarity 129, member Bb
chr20_+_42537768 1.50 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
chr19_-_5103313 1.49 ENSDART00000037007
triosephosphate isomerase 1a
chr25_-_37262220 1.43 ENSDART00000153789
ENSDART00000155182
ring finger and WD repeat domain 3
chr12_-_35582683 1.37 ENSDART00000167933
SEC24 homolog C, COPII coat complex component
chr4_-_13613148 1.31 ENSDART00000067164
ENSDART00000111247
interferon regulatory factor 5
chr23_-_24226533 1.30 ENSDART00000109134
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr12_-_35582521 1.27 ENSDART00000162175
ENSDART00000168958
SEC24 homolog C, COPII coat complex component
chr11_-_26832685 1.25 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr4_+_68562464 1.24 ENSDART00000192954

chr25_+_34862225 1.23 ENSDART00000149782
zgc:194879
chr6_+_13806466 1.23 ENSDART00000043522
transmembrane protein 198b
chr18_+_6706140 1.22 ENSDART00000111343
lipase maturation factor 2a
chr3_+_3610140 1.19 ENSDART00000104977
protein interacting with prkca 1
chr8_+_47219107 1.17 ENSDART00000146018
ENSDART00000075068
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_+_26640096 1.16 ENSDART00000067793
integrator complex subunit 3
chr13_-_51247529 1.14 ENSDART00000191774
ENSDART00000083788

chr3_-_34586403 1.13 ENSDART00000151515
septin 9a
chr15_+_35933094 1.13 ENSDART00000019976
rhomboid domain containing 1
chr18_-_21746421 1.13 ENSDART00000188809
protein serine kinase H1
chr10_-_32851847 1.12 ENSDART00000134255
tripartite motif containing 37
chr5_-_56943064 1.12 ENSDART00000146991
si:ch211-127d4.3
chr20_+_22799857 1.09 ENSDART00000058527
sec1 family domain containing 2
chr8_+_11471350 1.06 ENSDART00000092355
ENSDART00000136184
tight junction protein 2b (zona occludens 2)
chr6_-_29051773 1.06 ENSDART00000190508
ENSDART00000180191
ENSDART00000111682
ecotropic viral integration site 5b
chr5_+_65087226 1.06 ENSDART00000183187
peptidyl-tRNA hydrolase 1 homolog
chr5_+_6672870 1.05 ENSDART00000126598
paxillin a
chr2_-_7757273 1.04 ENSDART00000136074
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr12_+_30789611 1.03 ENSDART00000181501
aldehyde dehydrogenase 18 family, member A1
chr6_+_58289335 1.02 ENSDART00000177399
Ral GTPase activating protein, beta subunit (non-catalytic)
chr12_+_30788912 1.01 ENSDART00000160422
aldehyde dehydrogenase 18 family, member A1
chr19_+_7549854 1.00 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr4_-_8058214 1.00 ENSDART00000132228
WNK lysine deficient protein kinase 1b
chr17_+_19630272 1.00 ENSDART00000104895
regulator of G protein signaling 7a
chr5_+_65086668 0.99 ENSDART00000183746
peptidyl-tRNA hydrolase 1 homolog
chr16_-_42750295 0.98 ENSDART00000176570
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr10_+_20392083 0.98 ENSDART00000166867
R3H domain and coiled-coil containing 1
chr18_-_7481036 0.98 ENSDART00000101292
si:dkey-238c7.16
chr7_-_878473 0.97 ENSDART00000173567
si:cabz01080528.1
chr11_+_45286911 0.96 ENSDART00000181763
pyrroline-5-carboxylate reductase 1b
chr5_+_20453874 0.95 ENSDART00000124545
ENSDART00000008402
squamous cell carcinoma antigen recognized by T cells 3
chr9_-_27748868 0.94 ENSDART00000190306
TBCC domain containing 1
chr9_+_19623363 0.94 ENSDART00000142471
ENSDART00000147662
ENSDART00000136053
pyridoxal (pyridoxine, vitamin B6) kinase a
chr10_+_37173029 0.93 ENSDART00000136510
kinase suppressor of ras 1a
chr11_+_45287541 0.93 ENSDART00000165321
ENSDART00000173116
pyrroline-5-carboxylate reductase 1b
chr5_+_65086856 0.92 ENSDART00000169209
ENSDART00000162409
peptidyl-tRNA hydrolase 1 homolog
chr17_+_24446705 0.92 ENSDART00000163221
UDP-glucose pyrophosphorylase 2b
chr10_+_16165533 0.92 ENSDART00000065045
proline-rich coiled-coil 1
chr16_-_41717063 0.91 ENSDART00000084610
centrosomal protein 85
chr18_+_19990412 0.91 ENSDART00000155054
ENSDART00000090310
protein inhibitor of activated STAT, 1b
chr24_+_14214831 0.88 ENSDART00000004664
translocation associated membrane protein 1
chr17_+_24446353 0.87 ENSDART00000140467
UDP-glucose pyrophosphorylase 2b
chr22_-_817479 0.87 ENSDART00000123487
zgc:153675
chr23_-_36823932 0.85 ENSDART00000142305
homeodomain interacting protein kinase 1a
chr12_+_1592146 0.85 ENSDART00000184575
ENSDART00000192902
solute carrier family 39 member 11
chr3_-_33494163 0.83 ENSDART00000020342
small G protein signaling modulator 3
chr15_-_10341048 0.83 ENSDART00000171013
teneurin transmembrane protein 4
chr5_+_2002804 0.83 ENSDART00000064088
vitamin K epoxide reductase complex, subunit 1-like 1
chr7_+_32693890 0.82 ENSDART00000121972
solute carrier family 39 (zinc transporter), member 13
chr19_-_3482138 0.80 ENSDART00000168139
human immunodeficiency virus type I enhancer binding protein 1
chr23_-_18057851 0.80 ENSDART00000173075
ENSDART00000173230
ENSDART00000173135
ENSDART00000173431
ENSDART00000173068
ENSDART00000172987
zgc:92287
chr8_-_14554785 0.80 ENSDART00000057645
quiescin Q6 sulfhydryl oxidase 1
chr17_+_24445818 0.79 ENSDART00000139963
UDP-glucose pyrophosphorylase 2b
chr10_-_7472323 0.79 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
neuregulin 1
chr19_-_5103141 0.78 ENSDART00000150952
triosephosphate isomerase 1a
chr3_+_28860283 0.78 ENSDART00000077235
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr17_+_23730089 0.78 ENSDART00000034913
zgc:91976
chr25_+_3759553 0.77 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
THO complex 5
chr9_+_23825440 0.77 ENSDART00000138470
integrator complex subunit 6
chr7_-_69352424 0.76 ENSDART00000170714
adaptor-related protein complex 1, gamma 1 subunit
chr12_-_16452200 0.75 ENSDART00000037601
ribonuclease P/MRP 30 subunit
chr9_+_54695981 0.74 ENSDART00000183605
RAB9A, member RAS oncogene family
chr10_-_22150419 0.74 ENSDART00000006173
claudin 7b
chr17_-_15029639 0.74 ENSDART00000142941
endoplasmic reticulum oxidoreductase alpha
chr12_+_23991276 0.73 ENSDART00000153136
proteasome activator subunit 4b
chr15_-_18115540 0.72 ENSDART00000131639
ENSDART00000047902
archain 1b
chr2_-_55298075 0.72 ENSDART00000186404
ENSDART00000149062
RAB8A, member RAS oncogene family
chr10_-_26225548 0.72 ENSDART00000132019
ENSDART00000079194
ADP-ribosylation factor interacting protein 2b
chr1_+_10018466 0.71 ENSDART00000113551
tripartite motif containing 2b
chr6_-_32087108 0.71 ENSDART00000150934
ENSDART00000130627
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr5_+_61556172 0.70 ENSDART00000131937
ORAI calcium release-activated calcium modulator 2
chr6_-_42388608 0.69 ENSDART00000049425
Sec61 translocon alpha 1 subunit, like
chr4_+_77957611 0.68 ENSDART00000156692
ADP-ribosylation factor GTPase activating protein 3
chr21_-_22693730 0.66 ENSDART00000158342
grass carp reovirus (GCRV)-induced gene 2d
chr20_+_22799641 0.66 ENSDART00000131132
sec1 family domain containing 2
chr22_-_11078988 0.65 ENSDART00000126664
ENSDART00000006927
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr12_+_31783066 0.65 ENSDART00000105584
leucine rich repeat containing 59
chr8_-_24970790 0.65 ENSDART00000141267
si:ch211-199o1.2
chr3_-_59981162 0.64 ENSDART00000128790
cerebellar degeneration-related protein 2-like
chr17_+_24446533 0.63 ENSDART00000131417
UDP-glucose pyrophosphorylase 2b
chr17_+_19630068 0.63 ENSDART00000182619
regulator of G protein signaling 7a
chr3_+_53773256 0.63 ENSDART00000170461
collagen, type V, alpha 3a
chr11_+_44503774 0.63 ENSDART00000169295
endoplasmic reticulum oxidoreductase beta
chr20_-_40758410 0.63 ENSDART00000183031
connexin 34.5
chr20_+_16182948 0.62 ENSDART00000152708
zyg-11 homolog (C. elegans)
chr25_-_1687481 0.62 ENSDART00000163553
ENSDART00000179460
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr21_+_10076203 0.62 ENSDART00000190383

chr16_-_5115993 0.62 ENSDART00000138654
ttk protein kinase
chr11_+_6431133 0.62 ENSDART00000190742

chr16_+_53603945 0.61 ENSDART00000083513
SAC1 like phosphatidylinositide phosphatase b
chr7_+_31130667 0.61 ENSDART00000173937
tight junction protein 1a
chr9_-_53899106 0.60 ENSDART00000171986
component of oligomeric golgi complex 3
chr23_+_10396842 0.60 ENSDART00000167593
ENSDART00000125103
eukaryotic translation initiation factor 4Ba
chr8_-_31701157 0.59 ENSDART00000141799
F-box protein 4
chr9_+_25840720 0.59 ENSDART00000024572
glycosyltransferase-like domain containing 1
chr16_+_4078240 0.58 ENSDART00000160890
inositol polyphosphate-5-phosphatase B
chr23_+_22785375 0.56 ENSDART00000142085
arginine-glutamic acid dipeptide (RE) repeats a
chr16_-_36196700 0.56 ENSDART00000172324
calpain 7
chr11_-_44037692 0.55 ENSDART00000186333

chr20_-_1120056 0.55 ENSDART00000040680
RNA guanylyltransferase and 5'-phosphatase
chr13_+_42406883 0.54 ENSDART00000084354
cytoplasmic polyadenylation element binding protein 3
chr14_+_31566517 0.53 ENSDART00000002684
integrator complex subunit 6 like
chr22_-_10152629 0.53 ENSDART00000144209
RanBP-type and C3HC4-type zinc finger containing 1
chr2_+_45300512 0.53 ENSDART00000144704
calmodulin regulated spectrin-associated protein family, member 2b
chr16_+_6727195 0.53 ENSDART00000148625
zinc finger protein 407
chr8_+_47571211 0.53 ENSDART00000131460
phospholipase C, eta 2a
chr23_-_18057553 0.52 ENSDART00000173102
ENSDART00000058742
zgc:92287
chr20_+_49787584 0.52 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671

chr11_-_270210 0.52 ENSDART00000005217
ENSDART00000172779
aminolevulinate, delta-, synthase 1
chr12_+_19362335 0.51 ENSDART00000041711
G1 to S phase transition 1
chr23_+_43638982 0.51 ENSDART00000168646
solute carrier family 10, member 7
chr11_-_6420917 0.51 ENSDART00000193717

chr4_-_789645 0.50 ENSDART00000164441
microtubule-associated protein, RP/EB family, member 3b
chr1_+_46598764 0.50 ENSDART00000053240
calcium binding protein 39-like
chr16_-_54978981 0.50 ENSDART00000154023
WD and tetratricopeptide repeats 1
chr11_+_7276824 0.49 ENSDART00000185992
si:ch73-238c9.1
chr8_+_1291730 0.49 ENSDART00000192775
F-box and leucine-rich repeat protein 17
chr5_-_63644938 0.46 ENSDART00000050865
surfeit gene 4, like
chr17_+_6765621 0.46 ENSDART00000156637
ENSDART00000007622
AFG1 like ATPase a
chr1_-_53277187 0.45 ENSDART00000131520
zinc finger protein 330
chr3_+_34180835 0.45 ENSDART00000055252
translocase of inner mitochondrial membrane 29
chr15_-_32383340 0.45 ENSDART00000185632
complement component 4
chr6_+_26948093 0.45 ENSDART00000153595
FERM, RhoGEF and pleckstrin domain protein 2
chr6_+_49723289 0.43 ENSDART00000190452
syntaxin 16
chr6_+_23026714 0.43 ENSDART00000124948
signal recognition particle 68
chr15_-_29326254 0.42 ENSDART00000114492
si:dkey-52l18.4
chr14_-_45464112 0.42 ENSDART00000173209
EH-domain containing 1a
chr21_+_17016337 0.41 ENSDART00000065755
GPN-loop GTPase 3
chr7_-_65114067 0.41 ENSDART00000110614
ENSDART00000098277
transmembrane protein 41B
chr6_-_35052145 0.41 ENSDART00000073970
ENSDART00000185790
UDP-N-acetylglucosamine pyrophosphorylase 1
chr20_-_1191910 0.41 ENSDART00000043218
ubiquitin-conjugating enzyme E2, J1
chr21_-_44003457 0.40 ENSDART00000190647
arylsulfatase family, member Ib
chr19_-_46219035 0.40 ENSDART00000170601
si:ch1073-228h2.2
chr12_+_19362547 0.40 ENSDART00000180148
G1 to S phase transition 1
chr25_+_32157326 0.40 ENSDART00000112588
tight junction protein 1b
chr6_+_6779114 0.38 ENSDART00000163493
ENSDART00000143359
Sec23 homolog B, COPII coat complex component
chr3_+_33367954 0.38 ENSDART00000103161
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr2_+_34767171 0.37 ENSDART00000145451
astrotactin 1
chr22_+_1517318 0.37 ENSDART00000160406
si:ch211-255f4.5
chr1_+_38142715 0.36 ENSDART00000079928
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr15_-_16070731 0.36 ENSDART00000122099
dynein, light chain, LC8-type 2a
chr13_-_46917098 0.36 ENSDART00000183453
solute carrier family 29 (equilibrative nucleoside transporter), member 1a
chr9_+_34950942 0.36 ENSDART00000077800
transcription factor Dp-1, a
chr22_+_31295791 0.35 ENSDART00000092447
glutamate receptor interacting protein 2b
chr6_+_49722970 0.35 ENSDART00000155934
ENSDART00000154738
syntaxin 16
chr12_+_48480632 0.35 ENSDART00000158157
Rho GTPase activating protein 44
chr13_-_38088627 0.35 ENSDART00000175268

chr4_-_19693978 0.35 ENSDART00000100974
ENSDART00000040405
staphylococcal nuclease and tudor domain containing 1
chr21_-_2958422 0.35 ENSDART00000174091
zgc:194215
chr12_-_2869565 0.32 ENSDART00000152772
zinc finger, DHHC-type containing 16b
chr7_+_31339129 0.31 ENSDART00000173477
ENSDART00000114148
cancer susceptibility candidate 4
chr6_+_59854224 0.31 ENSDART00000083499
lysine (K)-specific demethylase 6A, like
chr3_-_36209936 0.31 ENSDART00000175208
casein kinase 1, delta a
chr21_-_17016105 0.30 ENSDART00000189120

chr5_-_14239078 0.30 ENSDART00000090788
neuropeptide FF receptor 1 like 2
chr15_+_28119284 0.29 ENSDART00000188366
unc-119 homolog a (C. elegans)
chr2_+_37176814 0.29 ENSDART00000048277
ENSDART00000176827
coatomer protein complex, subunit alpha
chr19_+_40248697 0.29 ENSDART00000151269
cyclin-dependent kinase 6
chr22_+_3238474 0.29 ENSDART00000157954
si:ch1073-178p5.3
chr13_+_36595618 0.27 ENSDART00000022684
cornichon family AMPA receptor auxiliary protein 1
chr18_-_18587745 0.27 ENSDART00000191973
splicing factor 3b, subunit 3
chr17_+_45737992 0.26 ENSDART00000135073
ENSDART00000143525
ENSDART00000158165
ENSDART00000184167
ENSDART00000109525
asparaginase homolog (S. cerevisiae)
chr2_-_9527129 0.26 ENSDART00000157422
ENSDART00000004398
coatomer protein complex, subunit epsilon
chr1_-_53277660 0.25 ENSDART00000014232
zinc finger protein 330
chr5_-_56964547 0.25 ENSDART00000074400
TIA1 cytotoxic granule-associated RNA binding protein
chr21_+_43882274 0.25 ENSDART00000075672
steroid receptor RNA activator 1
chr1_-_156375 0.25 ENSDART00000160221
PCI domain containing 2
chr6_-_52348562 0.24 ENSDART00000142565
ENSDART00000145369
ENSDART00000016890
eukaryotic translation initiation factor 6
chr14_-_16082806 0.24 ENSDART00000165656
MAX dimerization protein 3
chr5_-_30516646 0.23 ENSDART00000014666
archain 1a
chr6_+_47843760 0.23 ENSDART00000140943
peptidyl arginine deiminase, type II
chr17_+_22577472 0.22 ENSDART00000045099
Yip1 domain family, member 4
chr19_+_1414604 0.22 ENSDART00000159024
bloodthirsty-related gene family, member 29
chr11_+_7276983 0.21 ENSDART00000172407
ENSDART00000161176
ENSDART00000161041
ENSDART00000165536
si:ch73-238c9.1
chr9_+_30112423 0.21 ENSDART00000112398
ENSDART00000013591
trk-fused gene
chr14_+_8594367 0.21 ENSDART00000037749
syntaxin 5A
chr14_+_20351 0.21 ENSDART00000051893
syntaxin 18
chr3_+_27770110 0.21 ENSDART00000017962
enoyl-CoA delta isomerase 1
chr2_+_36608387 0.20 ENSDART00000159541
p21 protein (Cdc42/Rac)-activated kinase 2a
chr17_+_15213496 0.20 ENSDART00000058351
ENSDART00000131663
glucosamine-phosphate N-acetyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of xbp1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.6 2.3 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.5 1.9 GO:0051645 Golgi localization(GO:0051645)
0.4 3.9 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3 1.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.3 0.9 GO:0046184 aldehyde biosynthetic process(GO:0046184)
0.3 0.9 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 0.8 GO:0042373 vitamin K metabolic process(GO:0042373)
0.3 0.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.2 1.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 0.6 GO:1901993 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.2 3.0 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 1.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.2 0.9 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 0.7 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.2 0.8 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 2.1 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.6 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 1.0 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 1.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.4 GO:0016264 gap junction assembly(GO:0016264)
0.1 0.5 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.1 0.7 GO:0060876 semicircular canal formation(GO:0060876)
0.1 0.7 GO:0035092 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 4.7 GO:0036269 swimming behavior(GO:0036269)
0.1 0.8 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.1 0.6 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 1.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.2 GO:1902626 mature ribosome assembly(GO:0042256) assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.9 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.1 1.2 GO:0035999 methionine biosynthetic process(GO:0009086) tetrahydrofolate interconversion(GO:0035999)
0.1 3.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.1 GO:0061055 myotome development(GO:0061055)
0.1 0.6 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 3.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.0 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 0.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.2 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.4 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.7 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 0.9 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 1.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.2 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.7 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 1.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.9 GO:0001757 somite specification(GO:0001757)
0.0 0.3 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.5 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0090114 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 1.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.4 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 2.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.3 GO:0051607 defense response to virus(GO:0051607)
0.0 0.2 GO:0009648 photoperiodism(GO:0009648)
0.0 0.6 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 1.1 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.4 GO:0032456 endocytic recycling(GO:0032456)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.3 1.2 GO:0098842 postsynaptic early endosome(GO:0098842)
0.2 2.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.2 GO:0070876 SOSS complex(GO:0070876)
0.2 0.8 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.2 0.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 0.9 GO:0018444 translation release factor complex(GO:0018444)
0.2 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 1.1 GO:0016234 inclusion body(GO:0016234)
0.2 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 3.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.5 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 3.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 1.3 GO:0032039 integrator complex(GO:0032039)
0.1 0.4 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0070390 transcription export complex 2(GO:0070390)
0.0 1.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.1 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 1.8 GO:0030141 secretory granule(GO:0030141)
0.0 0.5 GO:0051233 microtubule plus-end(GO:0035371) spindle midzone(GO:0051233)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0043186 P granule(GO:0043186)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.6 2.3 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.4 3.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.4 2.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 1.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 1.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 3.5 GO:0005537 mannose binding(GO:0005537)
0.3 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 0.6 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.7 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 2.1 GO:0051117 ATPase binding(GO:0051117)
0.1 0.8 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.5 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.4 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.9 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 1.2 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.0 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 1.3 GO:0019894 kinesin binding(GO:0019894)
0.1 3.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.6 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.8 GO:0048038 quinone binding(GO:0048038)
0.0 0.7 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.8 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0004067 asparaginase activity(GO:0004067)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 1.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 3.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.5 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 2.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 3.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.2 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 3.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 0.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 2.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation