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PRJNA195909:zebrafish embryo and larva development
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Results for xbp1
Z-value: 1.49
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Transcription factors associated with xbp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| xbp1 | dr11_v1_chr5_-_15948833_15948920 | -0.29 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_34915886 Show fit | 3.49 |
ENSDART00000141201
ENSDART00000002166 |
cyclin A1 |
|
| chr12_+_10116912 Show fit | 2.73 |
ENSDART00000189630
|
si:dkeyp-118b1.2 |
|
| chr1_-_9485939 Show fit | 2.41 |
ENSDART00000157814
|
mical-like 2b |
|
| chr9_+_54237100 Show fit | 2.37 |
ENSDART00000148928
|
RNA binding motif protein 27 |
|
| chr1_-_9486214 Show fit | 2.27 |
ENSDART00000137821
|
mical-like 2b |
|
| chr5_+_24543862 Show fit | 2.09 |
ENSDART00000029699
|
ATPase H+ transporting V0 subunit a2b |
|
| chr1_-_23308225 Show fit | 1.96 |
ENSDART00000137567
ENSDART00000008201 |
small integral membrane protein 14 |
|
| chr21_+_10701834 Show fit | 1.78 |
ENSDART00000192473
|
lectin, mannose-binding, 1 |
|
| chr21_+_10702031 Show fit | 1.69 |
ENSDART00000102304
|
lectin, mannose-binding, 1 |
|
| chr11_+_30647545 Show fit | 1.54 |
ENSDART00000114792
|
expressed sequence EH507706 |
Network of associatons between targets according to the STRING database.
First level regulatory network of xbp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.4 | 3.9 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.1 | 3.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.1 | 3.5 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.6 | 3.2 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.2 | 3.0 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 2.5 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.6 | 2.3 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.1 | 2.1 | GO:0045851 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
| 0.5 | 1.9 | GO:0051645 | Golgi localization(GO:0051645) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 1.2 | 3.5 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.1 | 3.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.8 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 2.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 1.8 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 1.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 1.4 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.2 | 1.3 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 1.3 | GO:0032039 | integrator complex(GO:0032039) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 3.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.6 | 3.2 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.0 | 3.1 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.4 | 3.0 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 2.9 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.6 | 2.3 | GO:0004807 | triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929) |
| 0.1 | 2.1 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.4 | 2.0 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.4 | 1.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.4 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 1.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.1 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.2 | 3.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 2.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 2.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 2.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.7 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 1.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 1.2 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 1.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |