ISMARA results: wt1a+wt1b

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PRJNA195909:zebrafish embryo and larva development

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Results for wt1a+wt1b

Z-value: 1.44

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Transcription factors associated with wt1a+wt1b

Gene Symbol	Gene ID	Gene Info
wt1b NCBI UniProt	ENSDARG00000007990	WT1 transcription factor b
wt1a NCBI UniProt	ENSDARG00000031420	WT1 transcription factor a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
wt1a	dr11_v1_chr25_-_15214161_15214161	0.92	4.7e-04	Click!
wt1b	dr11_v1_chr18_-_45617146_45617146	0.78	1.2e-02	Click!

Activity profile of wt1a+wt1b motif

Sorted Z-values of wt1a+wt1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_47459723 Show fit	3.78	ENSDART00000015046	fstl1a NCBI UniProt Show fit	follistatin-like 1a
chr15_+_1397811 Show fit	3.42	ENSDART00000102125	schip1 NCBI UniProt Show fit	schwannomin interacting protein 1
chr9_-_39005317 Show fit	2.53	ENSDART00000014207	myl1 NCBI UniProt Show fit	myosin, light chain 1, alkali; skeletal, fast
chr2_-_22535 Show fit	2.39	ENSDART00000157877	CABZ01092282.1 NCBI UniProt Show fit
chr12_-_16764751 Show fit	2.34	ENSDART00000113862	zgc:174154 NCBI UniProt Show fit	zgc:174154
chr22_-_34872533 Show fit	2.18	ENSDART00000167176	slit1b NCBI UniProt Show fit	slit homolog 1b (Drosophila)
chr14_+_42172677 Show fit	2.12	ENSDART00000148544	pcdh18b NCBI UniProt Show fit	protocadherin 18b
chr19_+_1964005 Show fit	2.00	ENSDART00000172049	sh3bp5a NCBI UniProt Show fit	SH3-domain binding protein 5a (BTK-associated)
chr14_+_42172257 Show fit	1.91	ENSDART00000074362	pcdh18b NCBI UniProt Show fit	protocadherin 18b
chr3_+_32526263 Show fit	1.89	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of wt1a+wt1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	4.4	GO:0035332	positive regulation of hippo signaling(GO:0035332)
0.0	4.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	3.8	GO:0060034	notochord cell differentiation(GO:0060034)
0.0	3.4	GO:0010466	negative regulation of peptidase activity(GO:0010466)
0.0	2.7	GO:0008284	positive regulation of cell proliferation(GO:0008284)
0.1	2.2	GO:0021602	cranial nerve morphogenesis(GO:0021602)
0.2	2.0	GO:0061099	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1	2.0	GO:0045773	positive regulation of axon extension(GO:0045773)
0.1	1.9	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	1.9	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)

Showing 1 to 10 of 141 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0030027	lamellipodium(GO:0030027)
0.1	2.1	GO:0005869	dynactin complex(GO:0005869)
0.2	1.9	GO:0090533	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.3	1.6	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.6	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	1.6	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	1.5	GO:0044295	axonal growth cone(GO:0044295)
0.1	1.4	GO:0005801	cis-Golgi network(GO:0005801)
0.1	1.4	GO:0030057	desmosome(GO:0030057)
0.0	1.4	GO:0001725	stress fiber(GO:0001725) actomyosin(GO:0042641) contractile actin filament bundle(GO:0097517)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	14.3	GO:0005509	calcium ion binding(GO:0005509)
0.0	2.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	2.6	GO:0008201	heparin binding(GO:0008201)
0.0	2.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	2.2	GO:0003714	transcription corepressor activity(GO:0003714)
0.1	2.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	2.0	GO:0004860	protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1	1.9	GO:0001671	ATPase activator activity(GO:0001671)
0.0	1.9	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2	1.8	GO:0045294	alpha-catenin binding(GO:0045294)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	2.0	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	1.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	1.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	1.1	PID NECTIN PATHWAY	Nectin adhesion pathway
0.2	1.0	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	2.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	2.0	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.1	1.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.5	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	1.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	1.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions

Showing 1 to 10 of 33 entries

Results for wt1a+wt1b

Z-value: 1.44

Motif logo

Transcription factors associated with wt1a+wt1b

Activity-expression correlation:

Activity profile of wt1a+wt1b motif

Sorted Z-values of wt1a+wt1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of wt1a+wt1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: