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PRJNA195909:zebrafish embryo and larva development

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Results for tp73

Z-value: 1.05

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Transcription factors associated with tp73

Gene Symbol Gene ID Gene Info
tp73
ENSDARG00000017953 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp73dr11_v1_chr8_+_48848200_48848200-0.809.2e-03Click!

Activity profile of tp73 motif

Sorted Z-values of tp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_40837539 2.19 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr2_+_44528255 1.89 ENSDART00000193834
pask
PAS domain containing serine/threonine kinase
chr25_+_36292465 1.69 ENSDART00000152649
bmb
brambleberry
chr11_+_14333441 1.52 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr20_-_164300 1.42 ENSDART00000183354
si:ch211-241j12.3
si:ch211-241j12.3
chr2_-_7185460 1.37 ENSDART00000092078
rc3h1b
ring finger and CCCH-type domains 1b
chr16_+_39196727 1.08 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr16_-_21489514 1.01 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
mpp6a
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr5_+_6854498 0.99 ENSDART00000148663
elac1
elaC ribonuclease Z 1
chr20_+_4157815 0.97 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr13_+_33368140 0.91 ENSDART00000033848
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr22_+_24318131 0.86 ENSDART00000187360
ENSDART00000165618
ccdc50
coiled-coil domain containing 50
chr23_+_42254960 0.85 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr13_-_36418921 0.84 ENSDART00000135804
dcaf5
ddb1 and cul4 associated factor 5
chr4_+_23127104 0.81 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr14_+_15484544 0.81 ENSDART00000188649
CR382326.1

chr23_+_39346774 0.80 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr4_-_49607096 0.79 ENSDART00000154381
si:dkey-159n16.4
si:dkey-159n16.4
chr12_+_26608883 0.76 ENSDART00000153094
si:dkey-148d16.5
si:dkey-148d16.5
chr8_-_22739757 0.74 ENSDART00000182167
ENSDART00000171891
iqsec2a
IQ motif and Sec7 domain 2a
chr19_+_4068134 0.72 ENSDART00000158285
btr26
bloodthirsty-related gene family, member 26
chr23_+_39346930 0.72 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr22_-_9860792 0.70 ENSDART00000155908
si:dkey-253d23.2
si:dkey-253d23.2
chr18_-_38270077 0.69 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr5_-_18446483 0.68 ENSDART00000180027
si:dkey-215k6.1
si:dkey-215k6.1
chr4_+_23127284 0.64 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr7_-_16597130 0.63 ENSDART00000144118
e2f8
E2F transcription factor 8
chr7_-_16596938 0.63 ENSDART00000134548
e2f8
E2F transcription factor 8
chr3_+_31680592 0.63 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr2_+_23352302 0.62 ENSDART00000187760
rnf2
ring finger protein 2
chr13_-_17464654 0.61 ENSDART00000140312
lrmda
leucine rich melanocyte differentiation associated
chr11_+_12175162 0.57 ENSDART00000125446
si:ch211-156l18.7
si:ch211-156l18.7
chr22_+_8536838 0.56 ENSDART00000132998
si:ch73-27e22.7
si:ch73-27e22.7
chr18_+_44768829 0.55 ENSDART00000016271
ilvbl
ilvB (bacterial acetolactate synthase)-like
chr8_-_49623328 0.54 ENSDART00000139494
frmd3
FERM domain containing 3
chr6_+_13046720 0.54 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr4_+_23126558 0.54 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr1_+_57371447 0.53 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
si:dkey-27j5.3
chr13_-_17464362 0.53 ENSDART00000145499
lrmda
leucine rich melanocyte differentiation associated
chr12_-_3077395 0.52 ENSDART00000002867
ENSDART00000126315
rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_+_52545400 0.52 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr20_+_48100261 0.49 ENSDART00000158604
xkr5a
XK related 5a
chr25_-_3745393 0.45 ENSDART00000037973
morc2
MORC family CW-type zinc finger 2
chr22_+_12477996 0.44 ENSDART00000177704
CR847870.3

chr4_+_76304911 0.44 ENSDART00000172734
ENSDART00000161850
si:ch73-389k6.1
si:ch73-389k6.1
chr11_+_24348425 0.43 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr7_+_41314862 0.43 ENSDART00000185198
zgc:165532
zgc:165532
chr25_+_4581214 0.42 ENSDART00000185552
CABZ01068600.1

chr21_+_26612777 0.41 ENSDART00000142667
esrra
estrogen-related receptor alpha
chr19_+_4061699 0.40 ENSDART00000158309
ENSDART00000166512
btr25
btr26
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr3_+_62219158 0.36 ENSDART00000162354
BX470259.5

chr9_-_34121839 0.33 ENSDART00000000004
slc35a5
solute carrier family 35, member A5
chr2_+_37837249 0.32 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr11_+_24994705 0.32 ENSDART00000129211
zgc:92107
zgc:92107
chr7_-_72208248 0.31 ENSDART00000108916
zmp:0000001168
zmp:0000001168
chr14_+_22132896 0.25 ENSDART00000138274
ccng1
cyclin G1
chr22_+_15979430 0.23 ENSDART00000189703
ENSDART00000192674
rc3h1a
ring finger and CCCH-type domains 1a
chr20_-_7133546 0.23 ENSDART00000160910
si:ch211-121a2.4
si:ch211-121a2.4
chr19_-_7525588 0.22 ENSDART00000092256
mrpl9
mitochondrial ribosomal protein L9
chr11_-_8208464 0.22 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr5_-_26936861 0.22 ENSDART00000191032
htra4
HtrA serine peptidase 4
chr3_+_8825382 0.21 ENSDART00000158893
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr18_+_20567542 0.20 ENSDART00000182585
bida
BH3 interacting domain death agonist
chr9_-_52598343 0.18 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr6_-_40885496 0.18 ENSDART00000189857
sirt4
sirtuin 4
chr11_+_7528599 0.18 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr13_-_4707018 0.18 ENSDART00000128422
oit3
oncoprotein induced transcript 3
chr12_+_5358409 0.18 ENSDART00000152632
plce1
phospholipase C, epsilon 1
chr6_+_54888493 0.17 ENSDART00000113331
nav1b
neuron navigator 1b
chr8_+_52515188 0.15 ENSDART00000163668
si:ch1073-392o20.2
si:ch1073-392o20.2
chr18_+_32916351 0.13 ENSDART00000170387
ENSDART00000161553
olfcg2
olfactory receptor C family, g2
chr11_+_30303785 0.13 ENSDART00000185610
ENSDART00000126815
ugt1b5
UDP glucuronosyltransferase 1 family, polypeptide B5
chr10_-_40479911 0.12 ENSDART00000136741
taar20d1
trace amine associated receptor 20d1
chr11_+_24298432 0.09 ENSDART00000138487
si:dkey-76p14.2
si:dkey-76p14.2
chr22_-_31788170 0.09 ENSDART00000170925
pimr207
Pim proto-oncogene, serine/threonine kinase, related 207
chr5_-_62988463 0.07 ENSDART00000047143
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr11_-_8271374 0.06 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202
chr23_-_24047054 0.06 ENSDART00000184308
ENSDART00000185902
CR925720.1

chr4_+_25693463 0.04 ENSDART00000132864
acot18
acyl-CoA thioesterase 18
chr23_+_9258531 0.04 ENSDART00000138745
acss2
acyl-CoA synthetase short chain family member 2
chr7_-_73848458 0.04 ENSDART00000041385
zgc:163061
zgc:163061
chr13_-_50546634 0.03 ENSDART00000192127
CU570781.2

chr16_-_19568795 0.03 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr18_+_45676788 0.02 ENSDART00000109948
ENSDART00000179864
qser1
glutamine and serine rich 1
chr19_-_35400819 0.01 ENSDART00000148080
rnf19b
ring finger protein 19B
chr1_+_11711503 0.01 ENSDART00000138355
si:dkey-26i13.8
si:dkey-26i13.8

Network of associatons between targets according to the STRING database.

First level regulatory network of tp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.4 2.0 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.3 1.7 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.3 1.0 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.3 1.3 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.2 1.0 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.2 1.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.5 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.1 0.5 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 0.5 GO:0031649 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.4 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.1 0.6 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.5 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.5 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.9 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.2 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.0 1.6 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 1.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.1 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 2.2 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.4 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.0 GO:0046689 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005948 acetolactate synthase complex(GO:0005948)
0.1 0.9 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.6 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.5 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.2 1.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.1 GO:0019107 myristoyltransferase activity(GO:0019107)
0.2 0.5 GO:0003984 acetolactate synthase activity(GO:0003984)
0.2 1.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.9 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 1.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.3 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 ST STAT3 PATHWAY STAT3 Pathway
0.1 2.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi