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PRJNA195909:zebrafish embryo and larva development

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Results for tp63

Z-value: 0.93

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Transcription factors associated with tp63

Gene Symbol Gene ID Gene Info
tp63
ENSDARG00000044356 tumor protein p63
tp63
ENSDARG00000113627 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp63dr11_v1_chr6_+_28877306_288774410.636.9e-02Click!

Activity profile of tp63 motif

Sorted Z-values of tp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_36275633 1.88 ENSDART00000185027
ENSDART00000149532
ENSDART00000102883
ENSDART00000148444
zgc:86896
zgc:86896
chr24_+_35564668 1.84 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta
chr15_-_29387446 1.54 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr9_+_41103127 1.48 ENSDART00000000250
slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr23_-_17470146 1.47 ENSDART00000002398
trim101
tripartite motif containing 101
chr16_+_20904754 1.46 ENSDART00000006043
hoxa11b
homeobox A11b
chr23_-_19827411 1.37 ENSDART00000187964
haus7
HAUS augmin-like complex, subunit 7
chr14_-_9522364 1.30 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr11_-_11518469 1.23 ENSDART00000104254
krt15
keratin 15
chr17_-_32863250 1.21 ENSDART00000167292
prox1a
prospero homeobox 1a
chr18_+_17611627 1.12 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr1_+_36436936 1.05 ENSDART00000124112
pou4f2
POU class 4 homeobox 2
chr7_+_69653981 0.95 ENSDART00000090165
frem1a
Fras1 related extracellular matrix 1a
chr17_-_43466317 0.86 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr5_+_38913621 0.85 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr17_+_53250802 0.84 ENSDART00000143819
VASH1
vasohibin 1
chr17_-_7861219 0.82 ENSDART00000148604
syne1b
spectrin repeat containing, nuclear envelope 1b
chr7_-_50914526 0.81 ENSDART00000160398
ankrd46b
ankyrin repeat domain 46b
chr21_-_45613564 0.77 ENSDART00000160324
LO018363.1

chr10_-_10607118 0.74 ENSDART00000101089
dbh
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr8_-_26703195 0.73 ENSDART00000193439
ENSDART00000137968
si:dkey-159f12.2
si:dkey-159f12.2
chr10_+_39091353 0.71 ENSDART00000125986
si:ch73-1a9.4
si:ch73-1a9.4
chr14_+_24241241 0.71 ENSDART00000022377
nkx2.5
NK2 homeobox 5
chr10_+_25355308 0.71 ENSDART00000100415
map3k7cl
map3k7 C-terminal like
chr20_-_1314537 0.70 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr7_+_26138240 0.65 ENSDART00000193750
ENSDART00000184942
nat16
N-acetyltransferase 16
chr3_-_28120092 0.65 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr15_+_44053244 0.65 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr25_+_22107643 0.63 ENSDART00000089680
sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr25_+_34641536 0.59 ENSDART00000167033
CABZ01079011.1

chr10_+_5135842 0.58 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr20_-_1314355 0.56 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr12_+_22576404 0.56 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr13_-_12581388 0.55 ENSDART00000079655
enpep
glutamyl aminopeptidase
chr1_+_36651059 0.48 ENSDART00000187475
ednraa
endothelin receptor type Aa
chr3_-_50136424 0.47 ENSDART00000188843
btr02
bloodthirsty-related gene family, member 2
chr8_-_4694458 0.47 ENSDART00000019828
zgc:63587
zgc:63587
chr6_+_54538948 0.46 ENSDART00000149270
tulp1b
tubby like protein 1b
chr2_-_32501501 0.43 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr13_+_25422009 0.41 ENSDART00000057686
calhm2
calcium homeostasis modulator 2
chr11_+_691734 0.38 ENSDART00000191463
timp4.1
TIMP metallopeptidase inhibitor 4, tandem duplicate 1
chr4_-_52165969 0.37 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr8_+_2487883 0.34 ENSDART00000101841
dynll1
dynein, light chain, LC8-type 1
chr16_-_17207754 0.33 ENSDART00000063804
wu:fj39g12
wu:fj39g12
chr15_+_21672700 0.31 ENSDART00000187043
si:dkey-40g16.5
si:dkey-40g16.5
chr17_-_22324727 0.29 ENSDART00000160341
CU104709.1

chr20_-_25436389 0.29 ENSDART00000153266
itsn2a
intersectin 2a
chr23_+_44307996 0.29 ENSDART00000042430
dlg4b
discs, large homolog 4b (Drosophila)
chr7_+_8324506 0.28 ENSDART00000168110
si:dkey-185m8.2
si:dkey-185m8.2
chr12_-_4651988 0.27 ENSDART00000182836
si:ch211-255p10.4
si:ch211-255p10.4
chr12_+_45200744 0.27 ENSDART00000098932
wbp2
WW domain binding protein 2
chr8_-_38506339 0.25 ENSDART00000054558
ENSDART00000141623
foxb2
forkhead box B2
chr13_+_25421531 0.24 ENSDART00000158093
calhm2
calcium homeostasis modulator 2
chr5_+_69868911 0.24 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
ugt2a5
UDP glucuronosyltransferase 2 family, polypeptide A5
chr2_+_36691771 0.21 ENSDART00000131978
ptx3b
pentraxin 3, long b
chr22_+_21305682 0.20 ENSDART00000023521
odf3l2
outer dense fiber of sperm tails 3-like 2
chr7_-_56606752 0.20 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr7_-_60156409 0.19 ENSDART00000006802
cct7
chaperonin containing TCP1, subunit 7 (eta)
chr13_-_41908583 0.19 ENSDART00000136515
ipmka
inositol polyphosphate multikinase a
chr6_-_10902916 0.15 ENSDART00000122221
nfe2l2b
nuclear factor, erythroid 2-like 2b
chr7_-_8324927 0.15 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr17_-_14671098 0.13 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr14_-_733565 0.12 ENSDART00000158097
tlr1
toll-like receptor 1
chr7_+_22702437 0.12 ENSDART00000182054
si:dkey-165a24.9
si:dkey-165a24.9
chr17_-_14613711 0.11 ENSDART00000157345
sdsl
serine dehydratase-like
chr15_-_5157572 0.10 ENSDART00000174192
or128-10
odorant receptor, family E, subfamily 128, member 10
chr5_-_1999417 0.10 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr7_+_22702225 0.05 ENSDART00000173672
si:dkey-165a24.9
si:dkey-165a24.9
chr13_-_2060713 0.05 ENSDART00000038434
hcrtr2
hypocretin (orexin) receptor 2
chr10_-_5135788 0.03 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr1_+_52735484 0.02 ENSDART00000182076
CABZ01021532.1

chr17_+_38724473 0.02 ENSDART00000075792
GPR68
G protein-coupled receptor 68
chr2_-_37837472 0.01 ENSDART00000165347
mettl17
methyltransferase like 17

Network of associatons between targets according to the STRING database.

First level regulatory network of tp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.4 1.1 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.4 1.5 GO:0010039 response to iron ion(GO:0010039)
0.2 0.7 GO:0042420 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.2 0.7 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 0.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.5 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 1.2 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 1.9 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.6 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 1.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.8 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.1 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.0 0.9 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0051014 actin filament severing(GO:0051014)
0.0 1.4 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186)
0.0 0.1 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.7 GO:0021854 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.0 GO:0033334 fin morphogenesis(GO:0033334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.1 1.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.2 1.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 1.5 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 1.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 1.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 1.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME DEFENSINS Genes involved in Defensins