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PRJNA195909:zebrafish embryo and larva development

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Results for thraa+thrab

Z-value: 1.74

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Transcription factors associated with thraa+thrab

Gene Symbol Gene ID Gene Info
ENSDARG00000000151 thyroid hormone receptor alpha a
ENSDARG00000052654 thyroid hormone receptor alpha b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
thraadr11_v1_chr3_-_34724879_34724879-0.713.4e-02Click!
thrabdr11_v1_chr12_-_22039350_22039350-0.294.6e-01Click!

Activity profile of thraa+thrab motif

Sorted Z-values of thraa+thrab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_39185761 5.76 ENSDART00000075992
ENSDART00000140644
crystallin, beta A1b
chr9_-_22129788 3.66 ENSDART00000124272
ENSDART00000175417
crystallin, gamma M2d8
chr6_-_13783604 3.66 ENSDART00000149536
ENSDART00000041269
ENSDART00000150102
crystallin, beta A2a
chr10_-_44027391 3.57 ENSDART00000145404
crystallin, beta B1
chr21_+_39185461 3.55 ENSDART00000178419
crystallin, beta A1b
chr9_-_22135576 3.33 ENSDART00000101902
crystallin, gamma M2d8
chr9_-_22272181 3.29 ENSDART00000113174
crystallin, gamma M2d7
chr9_-_22245572 3.12 ENSDART00000114943
crystallin, gamma M2d4
chr20_-_40717900 3.01 ENSDART00000181663
connexin 43
chr12_-_30841679 2.87 ENSDART00000105594
crystallin, gamma MX
chr9_-_22299412 2.77 ENSDART00000139101
crystallin, gamma M2d21
chr9_-_22147567 2.74 ENSDART00000110941
crystallin, gamma M2d14
chr1_+_29096881 2.63 ENSDART00000075539
crystallin, alpha A
chr9_-_22205682 2.32 ENSDART00000101869
crystallin, gamma M2d12
chr9_-_22240052 2.27 ENSDART00000111109
crystallin, gamma M2d9
chr7_+_26716321 2.17 ENSDART00000189750
CD82 molecule a
chr2_+_42191592 2.07 ENSDART00000144716
caveolae associated protein 4a
chr3_-_38915998 2.04 ENSDART00000141886
si:dkey-106c17.2
chr1_+_16127825 1.96 ENSDART00000122503
tumor suppressor candidate 3
chr9_-_22023061 1.88 ENSDART00000101952
crystallin, gamma M2c
chr19_-_47456787 1.78 ENSDART00000168792
transcription factor AP-2 epsilon
chr13_-_16257848 1.74 ENSDART00000079745
zgc:110045
chr12_-_3133483 1.73 ENSDART00000015092
collagen, type I, alpha 1b
chr3_+_33300522 1.73 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr7_+_20017211 1.70 ENSDART00000100808
B-cell CLL/lymphoma 6, member B
chr24_-_39610585 1.63 ENSDART00000066506
cytochrome c oxidase subunit VIb polypeptide 1
chr3_-_18575868 1.59 ENSDART00000122968
aquaporin 8b
chr19_+_3653976 1.57 ENSDART00000125673
neural precursor cell expressed, developmentally down-regulated 9
chr13_-_31435137 1.56 ENSDART00000057441
reticulon 1a
chr10_+_6318227 1.51 ENSDART00000170872
ENSDART00000162428
ENSDART00000158994
tropomyosin 2 (beta)
chr17_+_23300827 1.49 ENSDART00000058745
zgc:165461
chr7_-_30082931 1.49 ENSDART00000075600
tetraspanin 3b
chr19_+_1184878 1.47 ENSDART00000163539
scratch family zinc finger 1a
chr4_-_16853464 1.46 ENSDART00000125743
ENSDART00000164570
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a
chr4_-_1360495 1.45 ENSDART00000164623
pleiotrophin
chr16_+_33655890 1.44 ENSDART00000143757
four and a half LIM domains 3a
chr11_-_31172276 1.44 ENSDART00000171520
si:dkey-238i5.3
chr21_-_41870029 1.40 ENSDART00000182035
endonuclease, polyU-specific 2
chr13_+_22249636 1.37 ENSDART00000108472
ENSDART00000173123
synaptopodin 2-like a
chr11_+_23265157 1.35 ENSDART00000110152
colony stimulating factor 1a (macrophage)
chr16_+_5774977 1.35 ENSDART00000134202
cholecystokinin a
chr7_-_41627956 1.34 ENSDART00000083929
plexin domain containing 2
chr8_-_16697615 1.33 ENSDART00000187929
retinal pigment epithelium-specific protein 65b
chr11_-_44543082 1.32 ENSDART00000099568
G protein-coupled receptor 137Bb
chr1_-_59176949 1.26 ENSDART00000128742

chr15_+_28096152 1.25 ENSDART00000100293
ENSDART00000140092
crystallin, beta B1, like 3
chr13_-_30645965 1.22 ENSDART00000109307
zinc finger, CCHC domain containing 24
chr4_+_42604252 1.22 ENSDART00000184850

chr20_+_30490682 1.22 ENSDART00000184871
myelin transcription factor 1-like, a
chr19_+_10341738 1.22 ENSDART00000128721
recoverin 3
chr10_+_22782522 1.21 ENSDART00000079498
ENSDART00000145558
si:ch211-237l4.6
chr8_-_2434282 1.21 ENSDART00000137262
ENSDART00000134044
voltage-dependent anion channel 3
chr7_+_31871830 1.20 ENSDART00000139899
myosin binding protein C, cardiac
chr13_-_36703164 1.19 ENSDART00000044357
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr19_+_30662529 1.19 ENSDART00000175662
family with sequence similarity 49, member A-like
chr11_+_45421761 1.19 ENSDART00000167347
HRAS-like suppressor
chr13_-_29424454 1.19 ENSDART00000026765
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr25_-_5740334 1.18 ENSDART00000169622
ENSDART00000168720

chr13_-_39947335 1.18 ENSDART00000056996
secreted frizzled-related protein 5
chr6_+_41463786 1.18 ENSDART00000065006
twinfilin actin-binding protein 2a
chr20_+_54738210 1.17 ENSDART00000151399
p21 protein (Cdc42/Rac)-activated kinase 7
chr7_-_17028015 1.16 ENSDART00000022441
developing brain homeobox 1a
chr23_-_11870962 1.16 ENSDART00000143481
si:dkey-178k16.1
chr2_+_33368414 1.14 ENSDART00000077462
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr20_-_26001288 1.14 ENSDART00000136518
ENSDART00000063177
calpain 3b
chr18_-_48492951 1.14 ENSDART00000146346
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr18_-_15373620 1.11 ENSDART00000031752
regulatory factor X, 4
chr23_-_16843649 1.10 ENSDART00000129971
si:dkey-63j12.4
chr7_+_29133321 1.10 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr3_+_23737795 1.10 ENSDART00000182247
homeobox B3a
chr18_+_36037223 1.06 ENSDART00000144410
transmembrane protein 91
chr14_+_36231126 1.05 ENSDART00000141766
ELOVL fatty acid elongase 6
chr4_+_30776883 1.03 ENSDART00000169519
si:dkey-11d20.1
chr6_+_1787160 1.02 ENSDART00000113505
myosin, light chain 9b, regulatory
chr23_-_4855122 1.01 ENSDART00000133701
solute carrier family 6 (neurotransmitter transporter), member 1a
chr25_-_29134654 1.01 ENSDART00000067066
poly (ADP-ribose) polymerase family, member 6b
chr4_-_16412084 1.00 ENSDART00000188460
decorin
chr4_+_42450386 0.99 ENSDART00000168211
si:dkey-11d20.1
chr3_-_29977495 0.99 ENSDART00000077111
hydroxysteroid (17-beta) dehydrogenase 14
chr16_+_50289916 0.98 ENSDART00000168861
ENSDART00000167332
hepcidin antimicrobial peptide
chr9_-_22892838 0.96 ENSDART00000143888
nebulin
chr17_-_27273296 0.96 ENSDART00000077087
inhibitor of DNA binding 3
chr6_-_60031693 0.96 ENSDART00000160275

chr11_+_45422206 0.89 ENSDART00000182548
HRAS-like suppressor
chr21_+_25688388 0.89 ENSDART00000125709
bicaudal-D-related protein 2
chr8_+_25902170 0.88 ENSDART00000193130
ras homolog gene family, member Ab
chr15_+_24644016 0.88 ENSDART00000043292
smoothelin, like
chr4_+_38344 0.87 ENSDART00000170197
ENSDART00000175348
putative homeodomain transcription factor 2
chr11_-_30138299 0.87 ENSDART00000172106
Scm polycomb group protein like 2
chr5_-_51747278 0.86 ENSDART00000192232
LHFPL tetraspan subfamily member 2b
chr16_+_22618620 0.85 ENSDART00000185728
ENSDART00000041625
cholinergic receptor, nicotinic, beta 2b
chr9_+_907459 0.83 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr9_+_54644626 0.83 ENSDART00000190609
EGF-like-domain, multiple 6
chr11_+_25477643 0.81 ENSDART00000065941
opsin 1 (cone pigments), long-wave-sensitive, 1
chr18_-_48517040 0.80 ENSDART00000143645
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr19_-_103289 0.79 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr19_-_24443394 0.79 ENSDART00000090825
thrombospondin 3b
chr7_+_36035432 0.79 ENSDART00000179004
iroquois homeobox 3a
chr14_-_7128980 0.77 ENSDART00000171311
si:ch73-43g23.1
chr11_-_11471857 0.77 ENSDART00000030103
keratin 94
chr10_-_44341288 0.75 ENSDART00000166131
zinc finger, SWIM-type containing 6
chr18_-_15932704 0.75 ENSDART00000127769
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr5_-_33286820 0.75 ENSDART00000184426
ribosomal protein L7a
chr18_-_48508585 0.74 ENSDART00000133364
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 4
chr14_-_42997145 0.74 ENSDART00000172801
protocadherin 10b
chr19_+_4912817 0.74 ENSDART00000101658
ENSDART00000165082
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr7_-_26924903 0.73 ENSDART00000124363
ALX homeobox 4a
chr4_+_75314247 0.71 ENSDART00000162365

chr10_-_39153959 0.69 ENSDART00000150193
ENSDART00000111362
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr10_+_8629275 0.69 ENSDART00000129643
apelin receptor b
chr10_-_39154594 0.69 ENSDART00000148825
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr3_-_36612877 0.69 ENSDART00000167164
si:dkeyp-72e1.7
chr15_-_35406564 0.68 ENSDART00000086051
MDS1 and EVI1 complex locus
chr11_-_1400507 0.68 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
ribosomal protein L29
chr5_-_29643381 0.68 ENSDART00000034849
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr21_-_45073764 0.68 ENSDART00000181390
ENSDART00000063714
Rap guanine nucleotide exchange factor (GEF) 6
chr19_-_24443867 0.67 ENSDART00000163763
ENSDART00000043133
thrombospondin 3b
chr1_+_34696503 0.66 ENSDART00000186106

chr18_+_8340886 0.64 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr16_-_46605160 0.63 ENSDART00000189070
ENSDART00000181194
transmembrane protein 176l.3a
chr2_-_28102264 0.63 ENSDART00000013638
cadherin 6
chr25_+_10830269 0.62 ENSDART00000175736
si:ch211-147g22.5
chr3_+_12484008 0.62 ENSDART00000182229
vasorin b
chr8_+_28259347 0.61 ENSDART00000110857
family with sequence similarity 212, member B
chr3_+_58379450 0.61 ENSDART00000155759
short chain dehydrogenase/reductase family 42E, member 2
chr23_+_30048849 0.61 ENSDART00000126027
urotensin 2, alpha
chr5_+_15350954 0.61 ENSDART00000140990
ENSDART00000137287
ENSDART00000061653
phosphatidylethanolamine binding protein 1
chr3_-_45777226 0.59 ENSDART00000192849
H3 histone, family 3B.1
chr17_+_24613255 0.58 ENSDART00000064738
ATP synthase inhibitory factor subunit 1b
chr8_-_25980694 0.58 ENSDART00000135456
si:dkey-72l14.3
chr1_-_45347393 0.58 ENSDART00000173024
si:ch211-243a20.4
chr12_+_34896956 0.57 ENSDART00000055415
peripherin 2a (retinal degeneration, slow)
chr5_-_30535327 0.57 ENSDART00000040328
H2A histone family, member X
chr15_-_28095532 0.57 ENSDART00000191490
crystallin, beta A1a
chr23_+_42810055 0.56 ENSDART00000186647
myosin, light chain 9a, regulatory
chr4_-_77432218 0.56 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr5_+_27440325 0.56 ENSDART00000185815
ENSDART00000144013
lysyl oxidase-like 2b
chr8_-_47818282 0.56 ENSDART00000137149
KN motif and ankyrin repeat domains 3
chr4_+_17280868 0.56 ENSDART00000145349
branched chain amino-acid transaminase 1, cytosolic
chr8_-_16712111 0.55 ENSDART00000184147
ENSDART00000180419
ENSDART00000076600
retinal pigment epithelium-specific protein 65c
chr1_+_23783349 0.55 ENSDART00000007531
slit homolog 2 (Drosophila)
chr4_+_15899668 0.55 ENSDART00000101592
collagen type VII alpha 1-like
chr2_-_44199722 0.54 ENSDART00000140633
ENSDART00000145728
succinate dehydrogenase complex, subunit C, integral membrane protein
chr7_-_72435159 0.54 ENSDART00000173060
rabphilin 3A homolog (mouse), b
chr25_-_15214161 0.54 ENSDART00000031499
wilms tumor 1a
chr17_+_389218 0.54 ENSDART00000162898
si:rp71-62i8.1
chr23_-_3703569 0.53 ENSDART00000143731
protein kinase C and casein kinase substrate in neurons 1a
chr2_+_6181383 0.53 ENSDART00000153307
si:ch73-344o19.1
chr20_+_45893173 0.52 ENSDART00000131169
bone morphogenetic protein 2b
chr10_+_35439952 0.52 ENSDART00000006284
HERV-H LTR-associating 2a, tandem duplicate 2
chr13_+_51869025 0.51 ENSDART00000187066

chr16_+_53125918 0.51 ENSDART00000102170

chr23_+_4373360 0.51 ENSDART00000144061
protein tyrosine phosphatase domain containing 1b
chr18_+_48943875 0.50 ENSDART00000076803

chr8_+_25352268 0.50 ENSDART00000187829
deoxyribonuclease I-like 1-like
chr1_-_45177373 0.49 ENSDART00000143142
ENSDART00000034549
zgc:111983
chr20_-_7992496 0.48 ENSDART00000145521
phospholipid phosphatase 3
chr25_-_36492779 0.48 ENSDART00000042271
iroquois homeobox 3b
chr9_-_11550711 0.48 ENSDART00000093343
FEV (ETS oncogene family)
chr13_+_23677949 0.47 ENSDART00000144215
pecanex-like 2 (Drosophila)
chr16_-_5721386 0.46 ENSDART00000136655
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
chr4_-_37479395 0.46 ENSDART00000168299
ENSDART00000157864
si:dkey-106c17.2
chr1_-_22512063 0.46 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr14_-_30390145 0.45 ENSDART00000045423
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr4_+_26496489 0.45 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr7_-_26308098 0.45 ENSDART00000146440
ENSDART00000146935
ENSDART00000164627
zgc:77439
chr16_+_5678071 0.45 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr9_+_17429170 0.44 ENSDART00000006256
zgc:101559
chr1_-_30039331 0.44 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr7_-_37812176 0.43 ENSDART00000164485
adenylate cyclase 7
chr18_+_45542981 0.43 ENSDART00000140357
kinesin family member C3
chr20_+_5564042 0.43 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr5_-_23277385 0.43 ENSDART00000134982
proteolipid protein 1b
chr16_-_44649053 0.43 ENSDART00000184807

chr5_+_23024033 0.43 ENSDART00000171199
chromatin modifying protein 1B
chr14_-_24332786 0.43 ENSDART00000173164
family with sequence similarity 13, member B
chr18_-_26785861 0.42 ENSDART00000098361
neuromedin Ba
chr10_+_22775253 0.41 ENSDART00000190141
transmembrane protein 88 a
chr20_+_36623807 0.41 ENSDART00000149171
ENSDART00000062895
signal recognition particle 9
chr9_+_21281652 0.41 ENSDART00000113352
large tumor suppressor kinase 2
chr2_-_4797512 0.41 ENSDART00000160765
tyrosine kinase, non-receptor, 2b
chr5_-_58840971 0.40 ENSDART00000050932
transmembrane protein 136b
chr11_+_6819050 0.40 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr6_+_29305190 0.40 ENSDART00000078647
si:ch211-201h21.5
chr2_+_24786765 0.39 ENSDART00000141030
phosphodiesterase 4C, cAMP-specific a
chr14_-_34771371 0.39 ENSDART00000160598
ENSDART00000150413
ENSDART00000168910
actin binding LIM protein family, member 3
chr8_-_7391721 0.39 ENSDART00000149836
LHFPL tetraspan subfamily member 4b
chr5_-_23277939 0.38 ENSDART00000003514
proteolipid protein 1b
chr24_+_26036395 0.38 ENSDART00000143485
tyrosine kinase, non-receptor, 2a
chr20_+_19793620 0.38 ENSDART00000136317
cholinergic receptor, nicotinic, alpha 2b (neuronal)
chr1_-_38813679 0.38 ENSDART00000148917
ankyrin repeat and SOCS box containing 5b
chr20_-_9755546 0.37 ENSDART00000152498
ENSDART00000152239
si:dkey-63j12.4
chr24_-_7995748 0.37 ENSDART00000158566
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr4_-_25271455 0.37 ENSDART00000066936
transmembrane protein 110, like
chr12_+_7491690 0.37 ENSDART00000152564
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr24_-_7995960 0.36 ENSDART00000186594
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr13_+_18663600 0.36 ENSDART00000141647
selenoprotein U 1a
chr22_+_26443235 0.36 ENSDART00000044085
zgc:92480
chr23_+_6232895 0.35 ENSDART00000139795
synaptotagmin IIa
chr5_-_30487822 0.35 ENSDART00000189288
ENSDART00000183201
pleckstrin homology-like domain, family B, member 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of thraa+thrab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:1901827 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.4 1.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.4 1.2 GO:0042908 xenobiotic transport(GO:0042908)
0.4 1.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.4 1.1 GO:0097264 self proteolysis(GO:0097264)
0.4 1.4 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.3 45.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.3 1.6 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.1 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.3 0.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 1.2 GO:0003210 cardiac atrium formation(GO:0003210)
0.2 0.7 GO:0072196 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.2 0.8 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.2 0.5 GO:0007414 axonal defasciculation(GO:0007414)
0.2 0.7 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.2 1.0 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 1.0 GO:0032570 response to progesterone(GO:0032570)
0.1 0.6 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.6 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 1.1 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.1 0.4 GO:1901296 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.1 0.5 GO:0061032 visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.1 0.4 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 1.2 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 2.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 0.5 GO:0035777 pronephric distal tubule development(GO:0035777)
0.1 0.2 GO:0090190 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 0.7 GO:0021794 thalamus development(GO:0021794)
0.1 0.2 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.5 GO:0097638 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 1.2 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.3 GO:0070983 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.1 1.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.3 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 0.3 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.6 GO:0032324 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 1.5 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 1.1 GO:1903672 positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.0 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.3 GO:0090497 mesenchymal cell migration(GO:0090497)
0.0 0.8 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 1.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.6 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.4 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.0 2.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0035094 response to nicotine(GO:0035094)
0.0 0.4 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 1.0 GO:0050654 chondroitin sulfate proteoglycan metabolic process(GO:0050654)
0.0 1.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.8 GO:0009648 photoperiodism(GO:0009648)
0.0 0.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.3 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.0 0.1 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 2.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.5 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0061036 positive regulation of chondrocyte differentiation(GO:0032332) positive regulation of cartilage development(GO:0061036)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0 0.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 2.5 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.2 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.8 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.4 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.8 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.4 GO:0007586 digestion(GO:0007586)
0.0 0.4 GO:0046058 cAMP biosynthetic process(GO:0006171) cAMP metabolic process(GO:0046058)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 2.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.5 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.6 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.2 GO:0046930 pore complex(GO:0046930)
0.1 0.8 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 2.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.8 GO:0043209 myelin sheath(GO:0043209)
0.0 3.9 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.2 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.5 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 45.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 1.9 GO:0050251 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.2 1.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 1.2 GO:0015288 porin activity(GO:0015288)
0.2 1.2 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 2.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 0.5 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.1 0.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.6 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.1 0.6 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.7 GO:0060182 apelin receptor activity(GO:0060182)
0.1 2.4 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 0.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 0.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.3 GO:0051380 norepinephrine binding(GO:0051380)
0.1 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.5 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.4 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.5 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.0 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.2 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.9 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.1 GO:0008201 heparin binding(GO:0008201)
0.0 0.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.3 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.3 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 8.5 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID ATM PATHWAY ATM pathway
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane