ISMARA results: thraa+thrab

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PRJNA195909:zebrafish embryo and larva development

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Results for thraa+thrab

Z-value: 1.74

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Transcription factors associated with thraa+thrab

Gene Symbol	Gene ID	Gene Info
thraa NCBI UniProt	ENSDARG00000000151	thyroid hormone receptor alpha a
thrab NCBI UniProt	ENSDARG00000052654	thyroid hormone receptor alpha b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
thraa	dr11_v1_chr3_-_34724879_34724879	-0.71	3.4e-02	Click!
thrab	dr11_v1_chr12_-_22039350_22039350	-0.29	4.6e-01	Click!

Activity profile of thraa+thrab motif

Sorted Z-values of thraa+thrab motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_39185761 Show fit	5.76	ENSDART00000075992 ENSDART00000140644	cryba1b NCBI UniProt Show fit	crystallin, beta A1b
chr9_-_22129788 Show fit	3.66	ENSDART00000124272 ENSDART00000175417	crygm2d8 NCBI UniProt Show fit	crystallin, gamma M2d8
chr6_-_13783604 Show fit	3.66	ENSDART00000149536 ENSDART00000041269 ENSDART00000150102	cryba2a NCBI UniProt Show fit	crystallin, beta A2a
chr10_-_44027391 Show fit	3.57	ENSDART00000145404	crybb1 NCBI UniProt Show fit	crystallin, beta B1
chr21_+_39185461 Show fit	3.55	ENSDART00000178419	cryba1b NCBI UniProt Show fit	crystallin, beta A1b
chr9_-_22135576 Show fit	3.33	ENSDART00000101902	crygm2d8 NCBI UniProt Show fit	crystallin, gamma M2d8
chr9_-_22272181 Show fit	3.29	ENSDART00000113174	crygm2d7 NCBI UniProt Show fit	crystallin, gamma M2d7
chr9_-_22245572 Show fit	3.12	ENSDART00000114943	crygm2d4 NCBI UniProt Show fit	crystallin, gamma M2d4
chr20_-_40717900 Show fit	3.01	ENSDART00000181663	cx43 NCBI UniProt Show fit	connexin 43
chr12_-_30841679 Show fit	2.87	ENSDART00000105594	crygmx NCBI UniProt Show fit	crystallin, gamma MX

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of thraa+thrab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	45.3	GO:0002088	lens development in camera-type eye(GO:0002088)
0.0	2.7	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.0	2.5	GO:0030833	regulation of actin filament polymerization(GO:0030833)
0.0	2.1	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.1	2.0	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.5	1.9	GO:1901827	tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.3	1.6	GO:0090527	actin filament reorganization(GO:0090527)
0.1	1.5	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.1	1.5	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.0	1.5	GO:0030318	melanocyte differentiation(GO:0030318)

Showing 1 to 10 of 94 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0030018	Z disc(GO:0030018)
0.0	2.1	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1	2.0	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	1.8	GO:0005581	collagen trimer(GO:0005581)
0.0	1.5	GO:0005865	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0	1.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.2	1.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	1.2	GO:0046930	pore complex(GO:0046930)
0.0	1.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	1.0	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	45.9	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	8.5	GO:0003779	actin binding(GO:0003779)
0.0	3.1	GO:0008201	heparin binding(GO:0008201)
0.2	2.7	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1	2.4	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.5	1.9	GO:0050251	retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.0	1.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.2	1.6	GO:0015250	water channel activity(GO:0015250)
0.1	1.5	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	1.4	GO:0004521	endoribonuclease activity(GO:0004521)

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	1.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.7	PID ATM PATHWAY	ATM pathway
0.0	0.6	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.4	PID IL3 PATHWAY	IL3-mediated signaling events

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	2.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	1.7	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	1.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.4	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	1.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	1.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.8	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening

Showing 1 to 10 of 19 entries

Results for thraa+thrab

Z-value: 1.74

Motif logo

Transcription factors associated with thraa+thrab

Activity-expression correlation:

Activity profile of thraa+thrab motif

Sorted Z-values of thraa+thrab motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of thraa+thrab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: