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PRJNA195909:zebrafish embryo and larva development
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Results for tfcp2+tfcp2l1+ubp1
Z-value: 1.37
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Transcription factors associated with tfcp2+tfcp2l1+ubp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tfcp2l1 | dr11_v1_chr9_+_38292947_38292947 | -0.43 | 2.5e-01 | Click! |
| ubp1 | dr11_v1_chr19_+_42806812_42806814 | -0.04 | 9.2e-01 | Click! |
| tfcp2 | dr11_v1_chr23_-_33680265_33680265 | 0.04 | 9.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_68795063 Show fit | 2.06 |
ENSDART00000016307
|
hairy-related 1 |
|
| chr22_+_22021936 Show fit | 1.51 |
ENSDART00000149586
|
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 |
|
| chr10_-_15048781 Show fit | 1.29 |
ENSDART00000038401
ENSDART00000155674 |
si:ch211-95j8.2 |
|
| chr13_+_18533005 Show fit | 1.26 |
ENSDART00000136024
|
finTRIM family, member 14-like |
|
| chr7_-_38792543 Show fit | 1.10 |
ENSDART00000157416
|
si:dkey-23n7.10 |
|
| chr13_+_28495419 Show fit | 1.06 |
ENSDART00000025583
|
fibroblast growth factor 8a |
|
| chr3_-_27647845 Show fit | 1.04 |
ENSDART00000151625
|
si:ch211-157c3.4 |
|
| chr4_-_48636872 Show fit | 1.03 |
ENSDART00000168605
|
zinc finger protein 1063 |
|
| chr17_+_51743908 Show fit | 1.00 |
ENSDART00000149039
ENSDART00000148869 |
ornithine decarboxylase 1 |
|
| chr24_+_38671054 Show fit | 0.96 |
ENSDART00000154214
|
si:ch73-70c5.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfcp2+tfcp2l1+ubp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:0001757 | somite specification(GO:0001757) |
| 0.1 | 1.5 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.2 | 1.1 | GO:0061194 | rhombomere 5 development(GO:0021571) rhombomere 6 development(GO:0021572) tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195) |
| 0.1 | 1.0 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.2 | 0.9 | GO:0055107 | Golgi to secretory granule transport(GO:0055107) |
| 0.1 | 0.9 | GO:0019372 | lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.0 | 0.9 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.3 | 0.8 | GO:0034382 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
| 0.3 | 0.8 | GO:0032757 | interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757) |
| 0.1 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 0.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 0.6 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 0.0 | 0.5 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.4 | GO:0071818 | BAT3 complex(GO:0071818) |
| 0.0 | 0.4 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.3 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 0.3 | GO:0070062 | extracellular exosome(GO:0070062) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 2.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 1.5 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.0 | 1.2 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 1.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.1 | 1.0 | GO:0004586 | ornithine decarboxylase activity(GO:0004586) |
| 0.1 | 0.9 | GO:0004051 | arachidonate 5-lipoxygenase activity(GO:0004051) |
| 0.3 | 0.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.8 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.2 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.5 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.3 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |