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PRJNA195909:zebrafish embryo and larva development
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Results for tfap4
Z-value: 2.19
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Transcription factors associated with tfap4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tfap4 | dr11_v1_chr3_-_12227359_12227359 | -0.18 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_20693743 Show fit | 5.79 |
ENSDART00000153023
ENSDART00000153370 |
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 2 |
|
| chr7_+_17947217 Show fit | 5.49 |
ENSDART00000101601
|
cysteine three histidine 1 |
|
| chr9_-_5351017 Show fit | 4.74 |
ENSDART00000082260
|
abhydrolase domain containing 13 |
|
| chr15_+_38299563 Show fit | 4.30 |
ENSDART00000099375
|
si:dkey-24p1.6 |
|
| chr11_+_45448212 Show fit | 4.06 |
ENSDART00000173341
|
son of sevenless homolog 1 (Drosophila) |
|
| chr4_-_17278904 Show fit | 3.60 |
ENSDART00000178686
ENSDART00000135730 |
lymphoid-restricted membrane protein |
|
| chr15_+_38308421 Show fit | 3.04 |
ENSDART00000129941
|
si:dkey-24p1.6 |
|
| chr13_-_2336584 Show fit | 2.93 |
ENSDART00000113692
|
transcription elongation factor B (SIII), polypeptide 3, like |
|
| chr14_-_34605607 Show fit | 2.66 |
ENSDART00000191608
|
actin filament associated protein 1-like 1a |
|
| chr5_-_9216758 Show fit | 2.57 |
ENSDART00000134896
ENSDART00000147000 |
low-density lipoprotein receptor related-protein 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfap4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0043413 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 0.0 | 3.9 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.2 | 3.6 | GO:0035046 | pronuclear migration(GO:0035046) |
| 0.0 | 3.6 | GO:0006897 | endocytosis(GO:0006897) |
| 0.2 | 3.4 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 3.2 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.2 | 2.9 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 2.8 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 0.0 | 2.7 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.1 | 2.6 | GO:0006998 | nuclear envelope organization(GO:0006998) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.2 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 6.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.4 | 5.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.7 | GO:0005813 | centrosome(GO:0005813) |
| 0.3 | 3.6 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 3.2 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 3.2 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 3.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 3.1 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 5.8 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 5.0 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.2 | 4.7 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 4.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 4.2 | GO:0032934 | sterol binding(GO:0032934) |
| 0.0 | 3.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.3 | 3.4 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.6 | 2.9 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 2.7 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 2.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.3 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 1.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 1.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 1.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 1.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.1 | 3.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 2.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.0 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 2.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 1.9 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 1.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 1.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |