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PRJNA195909:zebrafish embryo and larva development

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Results for tfap2b

Z-value: 1.06

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Transcription factors associated with tfap2b

Gene Symbol Gene ID Gene Info
tfap2b
ENSDARG00000012667 transcription factor AP-2 beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2bdr11_v1_chr20_-_47704973_47704973-0.501.7e-01Click!

Activity profile of tfap2b motif

Sorted Z-values of tfap2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_33857911 1.14 ENSDART00000165370
nxph2b
neurexophilin 2b
chr4_-_77551860 1.08 ENSDART00000188176
AL935186.6

chr4_-_77563411 1.02 ENSDART00000186841
AL935186.8

chr7_-_7420301 1.01 ENSDART00000102620
six7
SIX homeobox 7
chr4_-_20115570 0.97 ENSDART00000134528
si:dkey-159a18.1
si:dkey-159a18.1
chr15_-_32131 0.83 ENSDART00000099074
ENSDART00000164323
CYP2C9
si:zfos-411a11.2
chr17_-_26867725 0.82 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr12_+_30360184 0.81 ENSDART00000190718
si:ch211-225b10.3
si:ch211-225b10.3
chr13_+_32148338 0.74 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr17_-_26868169 0.73 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr12_-_8958353 0.62 ENSDART00000041728
cyp26a1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr7_+_48667081 0.60 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr12_+_30360579 0.57 ENSDART00000152900
si:ch211-225b10.3
si:ch211-225b10.3
chr18_+_24919614 0.52 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr18_+_40364732 0.52 ENSDART00000123661
ENSDART00000130847
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr15_-_20710 0.51 ENSDART00000161218
cyp2y3
cytochrome P450, family 2, subfamily Y, polypeptide 3
chr12_+_5708400 0.48 ENSDART00000017191
dlx3b
distal-less homeobox 3b
chr9_-_15424639 0.48 ENSDART00000124346
fn1a
fibronectin 1a
chr7_-_38570299 0.45 ENSDART00000143815
celf1
cugbp, Elav-like family member 1
chr16_+_26612401 0.41 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr7_-_38570878 0.40 ENSDART00000139187
ENSDART00000134570
ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr10_-_5135788 0.39 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr3_-_506241 0.38 ENSDART00000150141
si:dkey-12f6.5
si:dkey-12f6.5
chr22_+_508290 0.37 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr8_+_23861461 0.37 ENSDART00000037109
srpk1a
SRSF protein kinase 1a
chr25_+_17871089 0.36 ENSDART00000133725
btbd10a
BTB (POZ) domain containing 10a
chr12_+_638435 0.36 ENSDART00000152508
si:ch211-176g6.1
si:ch211-176g6.1
chr23_-_1017428 0.35 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr1_-_55248496 0.32 ENSDART00000098615
nanos3
nanos homolog 3
chr8_+_24281512 0.31 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr23_-_1017605 0.28 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr4_+_58667348 0.26 ENSDART00000186596
ENSDART00000180673
CR388148.2

chr21_-_27362938 0.26 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr7_+_529522 0.24 ENSDART00000190811
nrxn2b
neurexin 2b
chr7_+_34794829 0.23 ENSDART00000009698
ENSDART00000075089
ENSDART00000173456
esrp2
epithelial splicing regulatory protein 2
chr21_+_21205667 0.22 ENSDART00000058311
rictorb
RPTOR independent companion of MTOR, complex 2b
chr25_-_20870900 0.21 ENSDART00000171288
magi2b
membrane associated guanylate kinase, WW and PDZ domain containing 2b
chr5_-_15948833 0.21 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr1_+_5275811 0.21 ENSDART00000189676
spry2
sprouty RTK signaling antagonist 2
chr9_+_22764235 0.21 ENSDART00000090875
tnfaip6
tumor necrosis factor, alpha-induced protein 6
chr24_+_16149251 0.20 ENSDART00000188289
si:dkey-118j18.2
si:dkey-118j18.2
chr17_-_19019635 0.20 ENSDART00000126666
flrt2
fibronectin leucine rich transmembrane protein 2
chr21_-_34926619 0.20 ENSDART00000065337
ENSDART00000192740
kif20a
kinesin family member 20A
chr22_-_9906790 0.19 ENSDART00000105936
si:dkey-253d23.8
si:dkey-253d23.8
chr1_-_43987873 0.19 ENSDART00000108821
CR385050.1

chr24_+_42074143 0.18 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr4_+_5835393 0.18 ENSDART00000055414
pex26
peroxisomal biogenesis factor 26
chr6_-_59942335 0.18 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr14_-_51039702 0.16 ENSDART00000178932
cltb
clathrin, light chain B
chr25_+_30460378 0.16 ENSDART00000016310
banp
BTG3 associated nuclear protein
chr3_-_43646733 0.16 ENSDART00000180959
axin1
axin 1
chr25_+_6471401 0.14 ENSDART00000132927
snx33
sorting nexin 33
chr10_+_6383270 0.13 ENSDART00000170548
zgc:114200
zgc:114200
chr1_-_49544601 0.13 ENSDART00000145960
slc47a2.2
solute carrier family 47 (multidrug and toxin extrusion), member 2.2
chr16_+_20496691 0.12 ENSDART00000182737
ENSDART00000078984
cpvl
carboxypeptidase, vitellogenic-like
chr6_+_9867426 0.12 ENSDART00000151749
MPP4 (1 of many)
si:ch211-222n4.6
chr2_+_9918678 0.12 ENSDART00000081253
acbd5b
acyl-CoA binding domain containing 5b
chr2_+_9918935 0.12 ENSDART00000140434
acbd5b
acyl-CoA binding domain containing 5b
chr14_+_31509922 0.11 ENSDART00000124499
hprt1
hypoxanthine phosphoribosyltransferase 1
chr6_+_38381957 0.10 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr16_-_20435475 0.10 ENSDART00000139776
chn2
chimerin 2
chr7_+_21887787 0.10 ENSDART00000162252
pop7
POP7 homolog, ribonuclease P/MRP subunit
chr25_-_32363341 0.09 ENSDART00000153892
ENSDART00000114385
cep152
centrosomal protein 152
chr4_+_54439143 0.09 ENSDART00000170168
si:ch211-133h13.1
si:ch211-133h13.1
chr4_-_63980140 0.09 ENSDART00000160818
znf1091
zinc finger protein 1091
chr16_+_54209504 0.08 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr12_-_32013125 0.08 ENSDART00000153355
grin2cb
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr6_+_52931841 0.07 ENSDART00000174358
si:dkeyp-3f10.12
si:dkeyp-3f10.12
chr15_-_3736773 0.07 ENSDART00000090624
lpar6a
lysophosphatidic acid receptor 6a
chr7_-_48667056 0.07 ENSDART00000006378
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr20_-_47188966 0.07 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr6_-_2171818 0.06 ENSDART00000181082
ENSDART00000187556
PXMP4
wu:fe02h09
chr9_-_48864942 0.06 ENSDART00000113855
ENSDART00000189064
nostrin
nitric oxide synthase trafficking
chr17_-_29771639 0.05 ENSDART00000086201
ush2a
Usher syndrome 2A (autosomal recessive, mild)
chr1_-_23293261 0.05 ENSDART00000122648
ugdh
UDP-glucose 6-dehydrogenase
chr16_-_49846359 0.05 ENSDART00000184246
znf385d
zinc finger protein 385D
chr20_+_51199666 0.05 ENSDART00000169321
hsp90ab1
heat shock protein 90, alpha (cytosolic), class B member 1
chr20_+_30578967 0.05 ENSDART00000010494
fgfr1op
FGFR1 oncogene partner
chr8_-_37056622 0.05 ENSDART00000111513
si:ch211-218o21.4
si:ch211-218o21.4
chr4_+_37992753 0.04 ENSDART00000193890
CR759843.2

chr23_-_27701361 0.04 ENSDART00000186688
ENSDART00000183985
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr1_+_32528097 0.04 ENSDART00000128317
nlgn4a
neuroligin 4a
chr11_-_35975026 0.03 ENSDART00000186219
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr4_-_60790123 0.02 ENSDART00000137702
si:dkey-254e13.6
si:dkey-254e13.6
chr17_-_52609728 0.02 ENSDART00000103572
lrrc74a
leucine rich repeat containing 74A
chr2_-_9544161 0.02 ENSDART00000124425
slc25a24l
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr9_+_33334501 0.02 ENSDART00000006867
ddx3a
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
chr2_+_39108339 0.02 ENSDART00000085675
clstn2
calsyntenin 2
chr5_+_45921234 0.00 ENSDART00000134355
ankdd1b
ankyrin repeat and death domain containing 1B
chr24_+_37723362 0.00 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0048389 intermediate mesoderm development(GO:0048389)
0.2 0.9 GO:0061113 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.2 0.5 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.6 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.1 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 1.6 GO:0031641 regulation of myelination(GO:0031641)
0.1 0.3 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.5 GO:0006953 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) acute-phase response(GO:0006953) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.2 GO:0048785 hatching gland development(GO:0048785)
0.1 1.0 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.6 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.2 GO:0030910 olfactory placode formation(GO:0030910)
0.0 0.2 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.0 1.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.0 GO:0071634 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0043218 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.1 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.2 GO:0045495 pole plasm(GO:0045495)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 1.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.5 GO:0043394 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 0.2 GO:0070699 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.6 GO:0099604 ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.0 0.2 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage