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PRJNA195909:zebrafish embryo and larva development

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Results for tfap2a+tfap2c

Z-value: 0.50

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2adr11_v1_chr24_-_8732519_8732519-0.826.5e-03Click!
tfap2cdr11_v1_chr6_+_56147812_56147812-0.771.6e-02Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_1988036 0.70 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr7_+_39011852 0.63 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr3_-_54607166 0.63 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr11_-_28050559 0.63 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr3_+_3454610 0.62 ENSDART00000024900
zgc:165453
zgc:165453
chr23_-_35347714 0.58 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr2_+_30547018 0.57 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr15_+_6459847 0.57 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr3_-_55328548 0.55 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr2_+_11205795 0.54 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr15_-_24960730 0.52 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr2_+_11206317 0.50 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr24_-_21903360 0.49 ENSDART00000091252
spata13
spermatogenesis associated 13
chr24_-_21903588 0.49 ENSDART00000180991
spata13
spermatogenesis associated 13
chr5_+_63302660 0.49 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr16_-_46393154 0.47 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr1_+_27977297 0.44 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr15_+_44929497 0.44 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr16_+_26846495 0.43 ENSDART00000078124
trim35-29
tripartite motif containing 35-29
chr20_+_4157815 0.43 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr3_+_26244353 0.39 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr11_+_31324335 0.39 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr14_+_14806851 0.38 ENSDART00000169235
fhdc2
FH2 domain containing 2
chr19_-_30510930 0.38 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr14_+_29200772 0.37 ENSDART00000166608
TENM2
si:dkey-34l15.2
chr11_+_31323746 0.37 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr11_+_30253968 0.37 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr14_+_14806692 0.36 ENSDART00000193050
fhdc2
FH2 domain containing 2
chr16_+_26601364 0.35 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr5_+_6672870 0.33 ENSDART00000126598
pxna
paxillin a
chr5_+_25736979 0.33 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr7_-_15252540 0.32 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr1_+_16548733 0.32 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr3_-_26805455 0.30 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr1_+_58990121 0.30 ENSDART00000171654
CABZ01083166.1

chr7_+_32693890 0.29 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr18_-_15551360 0.28 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr3_-_26244256 0.28 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr8_-_11004726 0.25 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr8_-_26792912 0.24 ENSDART00000139787
kazna
kazrin, periplakin interacting protein a
chr3_-_35865040 0.24 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr1_-_25486471 0.24 ENSDART00000134200
ENSDART00000141892
ENSDART00000102501
arfip1
ADP-ribosylation factor interacting protein 1 (arfaptin 1)
chr13_-_36566260 0.22 ENSDART00000030133
synj2bp
synaptojanin 2 binding protein
chr16_-_5143124 0.19 ENSDART00000131876
ENSDART00000060630
ttk
ttk protein kinase
chr11_+_14333441 0.19 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr18_+_34181655 0.18 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr4_-_21466480 0.18 ENSDART00000139962
pawr
PRKC, apoptosis, WT1, regulator
chr8_-_4789034 0.17 ENSDART00000082256
ciao1
cytosolic iron-sulfur assembly component 1
chr1_+_26467071 0.17 ENSDART00000112329
ENSDART00000159318
ENSDART00000193833
ENSDART00000011809
uso1
USO1 vesicle transport factor
chr3_+_34846201 0.16 ENSDART00000055263
itga3a
integrin, alpha 3a
chr8_-_13211527 0.16 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr23_-_21215520 0.16 ENSDART00000143206
megf6a
multiple EGF-like-domains 6a
chr18_-_502722 0.15 ENSDART00000185757
sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr24_+_31374324 0.14 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr12_+_48744016 0.13 ENSDART00000175518
LO017648.1

chr1_-_45888608 0.13 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr23_-_9965148 0.13 ENSDART00000137308
plxnb1a
plexin b1a
chr14_-_45464112 0.13 ENSDART00000173209
ehd1a
EH-domain containing 1a
chr14_+_29609245 0.11 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr1_+_49878000 0.10 ENSDART00000047876
lef1
lymphoid enhancer-binding factor 1
chr19_+_10799929 0.10 ENSDART00000159152
lipea
lipase, hormone-sensitive a
chr9_+_32358514 0.08 ENSDART00000144608
plcl1
phospholipase C like 1
chr5_-_37933983 0.08 ENSDART00000185364
scn4bb
sodium channel, voltage-gated, type IV, beta b
chr1_+_42225060 0.07 ENSDART00000138740
ENSDART00000101306
ctnna2
catenin (cadherin-associated protein), alpha 2
chr4_-_11403811 0.06 ENSDART00000067272
ENSDART00000140018
pimr173
Pim proto-oncogene, serine/threonine kinase, related 173
chr2_+_28995776 0.06 ENSDART00000138733
cdh12a
cadherin 12, type 2a (N-cadherin 2)
chr11_+_14321113 0.06 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
ptbp1b
polypyrimidine tract binding protein 1b
chr18_-_31969939 0.05 ENSDART00000171516
olfcs1
olfactory receptor C family, s1
chr22_+_5971404 0.04 ENSDART00000122153
BX322587.1

chr5_-_41049690 0.04 ENSDART00000174936
ENSDART00000135030
pdzd2
PDZ domain containing 2
chr24_-_6898302 0.03 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr21_-_14773692 0.02 ENSDART00000142145
glulc
glutamate-ammonia ligase (glutamine synthase) c
chr21_-_45186431 0.00 ENSDART00000193449
si:ch73-269m14.2
si:ch73-269m14.2

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.2 GO:0044771 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.1 0.6 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.0 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.5 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.2 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)
0.0 0.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097361 CIA complex(GO:0097361)
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818)
0.1 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.1 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity