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PRJNA195909:zebrafish embryo and larva development
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Results for tbx3a+tbx3b
Z-value: 1.65
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Transcription factors associated with tbx3a+tbx3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbx3a | dr11_v1_chr5_-_72324371_72324371 | 0.87 | 2.6e-03 | Click! |
| tbx3b | dr11_v1_chr5_+_26913120_26913120 | 0.59 | 9.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_41990421 Show fit | 3.28 |
ENSDART00000055921
|
PYD and CARD domain containing |
|
| chr24_-_26283359 Show fit | 3.18 |
ENSDART00000128618
|
actinodin1 |
|
| chr12_+_27141140 Show fit | 2.98 |
ENSDART00000136415
|
homeobox B1b |
|
| chr6_+_15250672 Show fit | 2.86 |
ENSDART00000155951
|
si:ch73-23l24.1 |
|
| chr10_-_29903165 Show fit | 2.83 |
ENSDART00000078800
|
lens intrinsic membrane protein 2.1 |
|
| chr8_+_26818446 Show fit | 2.65 |
ENSDART00000134987
ENSDART00000138835 |
si:ch211-156j16.1 |
|
| chr7_-_73752955 Show fit | 2.61 |
ENSDART00000171254
ENSDART00000009888 |
calsequestrin 1b |
|
| chr12_-_26406323 Show fit | 2.56 |
ENSDART00000131896
|
myozenin 1b |
|
| chr20_-_26532167 Show fit | 2.33 |
ENSDART00000061914
|
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like |
|
| chr18_+_37272568 Show fit | 2.20 |
ENSDART00000132749
|
transmembrane protein 123 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tbx3a+tbx3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0033333 | fin development(GO:0033333) |
| 0.1 | 3.3 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.4 | 3.0 | GO:0021570 | rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661) |
| 0.9 | 2.6 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 2.3 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
| 0.5 | 2.1 | GO:0055107 | Golgi to secretory granule transport(GO:0055107) |
| 0.0 | 2.0 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.6 | 1.8 | GO:0038158 | granulocyte colony-stimulating factor signaling pathway(GO:0038158) |
| 0.4 | 1.6 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.3 | 1.4 | GO:0003228 | atrial cardiac muscle tissue development(GO:0003228) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.8 | 3.3 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.4 | 2.6 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 1.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 1.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 1.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 1.0 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.0 | 2.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 2.6 | GO:0051373 | telethonin binding(GO:0031433) FATZ binding(GO:0051373) |
| 0.3 | 2.3 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 2.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 1.4 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.1 | 1.3 | GO:0061608 | nuclear import signal receptor activity(GO:0061608) |
| 0.0 | 1.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 1.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.5 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.0 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 1.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |