ISMARA results: tbx15_tbx1_mgaa

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PRJNA195909:zebrafish embryo and larva development

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Results for tbx15_tbx1_mgaa_tbx4

Z-value: 1.66

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Transcription factors associated with tbx15_tbx1_mgaa_tbx4

Gene Symbol	Gene ID	Gene Info
tbx15 NCBI UniProt	ENSDARG00000002582	T-box transcription factor 15
tbx1 NCBI UniProt	ENSDARG00000031891	T-box transcription factor 1
mgaa NCBI UniProt	ENSDARG00000078784	MAX dimerization protein MGA a
tbx4 NCBI UniProt	ENSDARG00000030058	T-box transcription factor 4
tbx4 NCBI UniProt	ENSDARG00000113067	T-box transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbx1	dr11_v1_chr5_+_15202495_15202495	0.57	1.1e-01	Click!
mgaa	dr11_v1_chr17_+_10566490_10566495	-0.48	1.9e-01	Click!
tbx15	dr11_v1_chr9_-_21067673_21067673	0.37	3.3e-01	Click!
tbx4	dr11_v1_chr15_+_27384798_27384798	0.10	7.9e-01	Click!

Activity profile of tbx15_tbx1_mgaa_tbx4 motif

Sorted Z-values of tbx15_tbx1_mgaa_tbx4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_26965351 Show fit	3.52	ENSDART00000114215 ENSDART00000147192	grhl3 NCBI UniProt Show fit	grainyhead-like transcription factor 3
chr17_-_42568498 Show fit	3.35	ENSDART00000014296	foxa2 NCBI UniProt Show fit	forkhead box A2
chr23_+_23232136 Show fit	3.34	ENSDART00000126479 ENSDART00000187764	plekhn1 NCBI UniProt Show fit	pleckstrin homology domain containing, family N member 1
chr11_-_11575070 Show fit	3.31	ENSDART00000142208	zgc:110712 NCBI UniProt Show fit	zgc:110712
chr7_-_58776400 Show fit	2.87	ENSDART00000167433	sox17 NCBI UniProt Show fit	SRY (sex determining region Y)-box 17
chr25_-_11016675 Show fit	2.79	ENSDART00000099572	mespab NCBI UniProt Show fit	mesoderm posterior ab
chr15_-_1590858 Show fit	2.59	ENSDART00000081875	nnr NCBI UniProt Show fit	nanor
chr1_-_12126535 Show fit	2.57	ENSDART00000164817 ENSDART00000015251	mttp NCBI UniProt Show fit	microsomal triglyceride transfer protein
chr6_+_56141852 Show fit	2.55	ENSDART00000149665	tfap2c NCBI UniProt Show fit	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr13_+_14976108 Show fit	2.35	ENSDART00000011520	noto NCBI UniProt Show fit	notochord homeobox

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx15_tbx1_mgaa_tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.6	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.2	3.5	GO:0060325	face morphogenesis(GO:0060325)
0.8	3.3	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.6	3.0	GO:0032289	central nervous system myelin formation(GO:0032289)
0.7	2.9	GO:0048338	axial mesoderm structural organization(GO:0048331) mesoderm structural organization(GO:0048338)
0.7	2.6	GO:0009957	epidermal cell fate specification(GO:0009957)
0.3	2.6	GO:0001579	medium-chain fatty acid transport(GO:0001579)
0.2	2.6	GO:0014036	neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0	2.6	GO:0031101	fin regeneration(GO:0031101)
0.6	2.5	GO:0060829	negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)

Showing 1 to 10 of 144 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0005882	intermediate filament(GO:0005882)
0.3	2.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	2.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.0	GO:0016324	apical plasma membrane(GO:0016324)
0.0	1.8	GO:0016605	PML body(GO:0016605)
0.0	1.6	GO:0000421	autophagosome membrane(GO:0000421)
0.0	1.2	GO:0016592	mediator complex(GO:0016592)
0.0	1.1	GO:0031672	A band(GO:0031672)
0.2	1.0	GO:0043034	costamere(GO:0043034)
0.1	1.0	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.1	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	4.3	GO:0019904	protein domain specific binding(GO:0019904)
0.0	3.9	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.1	3.3	GO:1901612	cardiolipin binding(GO:1901612)
0.6	2.6	GO:1904121	phosphatidylethanolamine transporter activity(GO:1904121)
0.1	2.2	GO:0005112	Notch binding(GO:0005112)
0.3	2.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.2	2.0	GO:0004046	aminoacylase activity(GO:0004046)
0.2	1.8	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3	1.7	GO:0042974	retinoic acid receptor binding(GO:0042974)

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	2.9	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	2.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.5	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	1.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	0.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.3	2.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	1.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	1.5	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1	1.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	0.7	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.6	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	0.5	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 20 entries

Results for tbx15_tbx1_mgaa_tbx4

Z-value: 1.66

Motif logo

Transcription factors associated with tbx15_tbx1_mgaa_tbx4

Activity-expression correlation:

Activity profile of tbx15_tbx1_mgaa_tbx4 motif

Sorted Z-values of tbx15_tbx1_mgaa_tbx4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx15_tbx1_mgaa_tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: