ISMARA results: tbp

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PRJNA195909:zebrafish embryo and larva development

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Results for tbp

Z-value: 6.88

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Transcription factors associated with tbp

Gene Symbol	Gene ID	Gene Info
tbp NCBI UniProt	ENSDARG00000014994	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tbp	dr11_v1_chr13_-_24396003_24396003	-0.93	2.9e-04	Click!

Activity profile of tbp motif

Sorted Z-values of tbp motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_22240052 Show fit	24.81	ENSDART00000111109	crygm2d9 NCBI UniProt Show fit	crystallin, gamma M2d9
chr9_-_22232902 Show fit	24.34	ENSDART00000101845	crygm2d5 NCBI UniProt Show fit	crystallin, gamma M2d5
chr3_-_32818607 Show fit	20.16	ENSDART00000075465	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr9_-_22245572 Show fit	19.25	ENSDART00000114943	crygm2d4 NCBI UniProt Show fit	crystallin, gamma M2d4
chr9_-_22158784 Show fit	19.12	ENSDART00000167850	crygm2d14 NCBI UniProt Show fit	crystallin, gamma M2d14
chr9_-_22299412 Show fit	18.76	ENSDART00000139101	crygm2d21 NCBI UniProt Show fit	crystallin, gamma M2d21
chr9_-_22281854 Show fit	18.07	ENSDART00000146319	crygm2d3 NCBI UniProt Show fit	crystallin, gamma M2d3
chr9_-_22213297 Show fit	18.00	ENSDART00000110656 ENSDART00000133149	crygm2d20 NCBI UniProt Show fit	crystallin, gamma M2d20
chr9_-_22135576 Show fit	17.12	ENSDART00000101902	crygm2d8 NCBI UniProt Show fit	crystallin, gamma M2d8
chr12_-_17712393 Show fit	16.44	ENSDART00000143534 ENSDART00000010144	pvalb2 NCBI UniProt Show fit	parvalbumin 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	317.2	GO:0002088	lens development in camera-type eye(GO:0002088)
2.4	26.4	GO:0019731	antibacterial humoral response(GO:0019731)
0.7	23.2	GO:0060030	dorsal convergence(GO:0060030)
0.2	17.4	GO:0031101	fin regeneration(GO:0031101)
3.3	16.4	GO:0010872	regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
1.1	14.5	GO:0046314	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.6	13.7	GO:0000028	ribosomal small subunit assembly(GO:0000028)
4.5	13.6	GO:1905072	cardiac jelly development(GO:1905072)
4.5	13.4	GO:0071831	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
4.2	12.7	GO:0006601	creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)

Showing 1 to 10 of 123 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	58.5	GO:0005615	extracellular space(GO:0005615)
0.4	40.3	GO:0005882	intermediate filament(GO:0005882)
0.0	26.8	GO:0005576	extracellular region(GO:0005576)
0.1	18.6	GO:0016459	myosin complex(GO:0016459)
0.2	18.3	GO:0055037	recycling endosome(GO:0055037)
1.4	16.4	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	15.6	GO:0005764	lysosome(GO:0005764)
0.4	14.4	GO:0001750	photoreceptor outer segment(GO:0001750)
2.8	13.8	GO:0005883	neurofilament(GO:0005883)
0.0	13.6	GO:0005743	mitochondrial inner membrane(GO:0005743)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.9	313.6	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	59.8	GO:0005509	calcium ion binding(GO:0005509)
0.1	51.4	GO:0005198	structural molecule activity(GO:0005198)
0.2	33.7	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	22.3	GO:0003774	motor activity(GO:0003774)
3.3	16.4	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.1	14.5	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2	14.4	GO:0051427	hormone receptor binding(GO:0051427)
4.5	13.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.4	12.7	GO:0016769	transferase activity, transferring nitrogenous groups(GO:0016769)

Showing 1 to 10 of 104 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	9.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	8.1	PID AP1 PATHWAY	AP-1 transcription factor network
0.4	6.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	6.3	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	6.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.5	5.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	4.5	PID FOXO PATHWAY	FoxO family signaling
0.1	2.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	2.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	21.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	16.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.6	12.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3	10.0	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
1.0	9.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4	8.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	7.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.8	7.3	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	6.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	6.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Showing 1 to 10 of 32 entries

Results for tbp

Z-value: 6.88

Motif logo

Transcription factors associated with tbp

Activity-expression correlation:

Activity profile of tbp motif

Sorted Z-values of tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: