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PRJNA195909:zebrafish embryo and larva development

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Results for stat5a+stat5b

Z-value: 0.69

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Transcription factors associated with stat5a+stat5b

Gene Symbol Gene ID Gene Info
ENSDARG00000019392 signal transducer and activator of transcription 5a
ENSDARG00000055588 signal transducer and activator of transcription 5b
ENSDARG00000113871 signal transducer and activator of transcription 5a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat5bdr11_v1_chr12_-_13650344_136504720.646.6e-02Click!
stat5adr11_v1_chr3_+_17251542_172515420.412.8e-01Click!

Activity profile of stat5a+stat5b motif

Sorted Z-values of stat5a+stat5b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_55100045 0.74 ENSDART00000113098
hemoglobin, alpha adult 1
chr7_+_58751504 0.59 ENSDART00000024185
zgc:56231
chr22_+_7480465 0.53 ENSDART00000034545
zgc:92745
chr14_-_32631519 0.49 ENSDART00000167282
ENSDART00000052938
ATPase phospholipid transporting 11C
chr5_+_32141790 0.47 ENSDART00000041504
tescalcin b
chr16_+_25171832 0.46 ENSDART00000156416
wu:fe05a04
chr23_-_1571682 0.44 ENSDART00000013635
F-box protein 30b
chr6_+_41503854 0.43 ENSDART00000136538
ENSDART00000140108
ENSDART00000084861
cytokine inducible SH2-containing protein
chr17_+_44463230 0.40 ENSDART00000130311
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr18_-_20444296 0.38 ENSDART00000132993
kinesin family member 23
chr13_+_6092135 0.37 ENSDART00000162738
family with sequence similarity 120B
chr15_+_2857556 0.36 ENSDART00000157758
MRE11 homolog A, double strand break repair nuclease
chr6_-_43283122 0.35 ENSDART00000186022
FERM domain containing 4Ba
chr16_+_25126935 0.35 ENSDART00000058945
zgc:92590
chr10_+_44700103 0.35 ENSDART00000165999
scavenger receptor class B, member 1
chr5_-_16791223 0.35 ENSDART00000192744
ATPase family, AAA domain containing 1a
chr10_+_44699734 0.35 ENSDART00000167952
ENSDART00000158681
ENSDART00000190188
ENSDART00000168276
scavenger receptor class B, member 1
chr13_+_2861265 0.34 ENSDART00000170602
ENSDART00000171687
si:ch211-233m11.2
chr16_-_41787421 0.34 ENSDART00000147210
si:dkey-199f5.8
chr7_+_53254234 0.33 ENSDART00000169830
thyroid hormone receptor interactor 4
chr19_+_15443063 0.33 ENSDART00000151732
lin-28 homolog A (C. elegans)
chr22_-_9861531 0.33 ENSDART00000193197
si:dkey-253d23.2
chr21_-_14692119 0.32 ENSDART00000123047
euchromatic histone-lysine N-methyltransferase 1b
chr17_+_6536152 0.31 ENSDART00000062952
ENSDART00000121789
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr4_+_13586455 0.31 ENSDART00000187230
transportin 3
chr15_-_23485752 0.31 ENSDART00000152706
NLR family member X1
chr2_+_22659787 0.31 ENSDART00000043956
zgc:161973
chr20_+_28803642 0.30 ENSDART00000188526
farnesyltransferase, CAAX box, beta
chr7_+_17106160 0.30 ENSDART00000190048
ENSDART00000180004
ENSDART00000013409
protein arginine methyltransferase 3
chr1_-_9195629 0.29 ENSDART00000143587
ENSDART00000192174
endoplasmic reticulum to nucleus signaling 2
chr7_+_29890292 0.28 ENSDART00000170403
ENSDART00000168600
talin 2a
chr12_-_23365737 0.27 ENSDART00000170376
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr25_+_33063762 0.27 ENSDART00000189974
talin 2b
chr20_+_28803977 0.27 ENSDART00000153351
ENSDART00000038149
farnesyltransferase, CAAX box, beta
chr20_-_3238110 0.27 ENSDART00000008077
serine peptidase inhibitor, Kunitz type 1 b
chr7_-_11605185 0.27 ENSDART00000169291
ENSDART00000113904
StAR-related lipid transfer (START) domain containing 5
chr11_+_36409457 0.26 ENSDART00000077641
cytochrome b561 family, member D1
chr23_+_26017227 0.26 ENSDART00000002939
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr8_+_247163 0.26 ENSDART00000122378
centrosomal protein 120
chr2_-_42035250 0.26 ENSDART00000056460
ENSDART00000140788
guanylate binding protein 1
chr24_-_25166416 0.26 ENSDART00000111552
ENSDART00000169495
pleckstrin homology-like domain, family B, member 2b
chr18_+_41772474 0.26 ENSDART00000097547
transient receptor potential cation channel, subfamily C, member 6b
chr17_-_24521382 0.26 ENSDART00000092948
pellino E3 ubiquitin protein ligase 1b
chr14_-_6987649 0.25 ENSDART00000060990
eukaryotic translation initiation factor 4E binding protein 3, like
chr8_+_25959940 0.25 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
chr17_-_6536466 0.24 ENSDART00000188735
centromere protein O
chr24_-_25166720 0.24 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr6_-_37499574 0.24 ENSDART00000023163
jade family PHD finger 3
chr17_-_6536305 0.23 ENSDART00000154855
centromere protein O
chr6_-_53048291 0.23 ENSDART00000103267
family with sequence similarity 212, member Ab
chr15_+_37412883 0.22 ENSDART00000156474
zinc finger and BTB domain containing 32
chr1_+_230363 0.22 ENSDART00000153285
transcription factor Dp-1, b
chr21_+_37090585 0.21 ENSDART00000182971
zinc finger protein 346
chr5_-_42071505 0.21 ENSDART00000137224
ENSDART00000193721
chemokine (C-X-C motif) ligand 11, duplicate 7
centromere protein V
chr6_-_18393476 0.21 ENSDART00000168309
tripartite motif containing 25
chr5_+_20366453 0.20 ENSDART00000193141
coronin, actin binding protein, 1Ca
chr10_-_7821686 0.20 ENSDART00000121531
methionine adenosyltransferase II, alpha a
chr20_-_2361226 0.20 ENSDART00000172130
si:ch73-18b11.1
chr3_+_39656188 0.20 ENSDART00000186292
ENSDART00000156038
epsin 2
chr3_+_35608385 0.19 ENSDART00000193219
ENSDART00000132703
TNF receptor-associated factor 7
chr11_-_34518362 0.19 ENSDART00000188223
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr10_-_41352502 0.19 ENSDART00000052971
ENSDART00000128156
RAB11 family interacting protein 1 (class I) b
chr2_-_42109575 0.18 ENSDART00000075551
alcohol dehydrogenase, iron containing, 1
chr8_+_19548985 0.18 ENSDART00000123104
notch 2
chr11_+_13024002 0.17 ENSDART00000104113
basic transcription factor 3-like 4
chr15_-_32383340 0.17 ENSDART00000185632
complement component 4
chr3_-_26904774 0.16 ENSDART00000103690
C-type lectin domain containing 16A
chr19_+_7759354 0.14 ENSDART00000151400
ubiquitin associated protein 2-like
chr19_+_1673599 0.14 ENSDART00000163127
kelch-like family member 7
chr13_-_17464654 0.14 ENSDART00000140312
leucine rich melanocyte differentiation associated
chr13_-_49819027 0.14 ENSDART00000067824
beta-1,3-N-acetylgalactosaminyltransferase 2
chr24_+_25032340 0.12 ENSDART00000005845
myotubularin related protein 6
chr20_+_25586099 0.12 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr7_-_38687431 0.12 ENSDART00000074490
apelin receptor 2
chr5_-_42883761 0.12 ENSDART00000167374

chr5_-_42878178 0.12 ENSDART00000162981
C-X-C motif chemokine ligand 11
chr5_+_27137473 0.11 ENSDART00000181833
unc-5 netrin receptor Db
chr7_+_17303944 0.11 ENSDART00000163505
ENSDART00000162169
ENSDART00000161291
novel immune-type receptor 9
chr19_-_43757568 0.11 ENSDART00000058491
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr18_+_6479963 0.11 ENSDART00000092752
ENSDART00000136333
WAS protein family homolog 1
chr2_-_3611960 0.11 ENSDART00000184579
phosphotriesterase related
chr17_+_46864116 0.10 ENSDART00000156250
Pim proto-oncogene, serine/threonine kinase, related 27
chr7_-_31922432 0.10 ENSDART00000188398
lin-7 homolog C (C. elegans)
chr6_-_37749711 0.10 ENSDART00000078324
non imprinted in Prader-Willi/Angelman syndrome 1
chr22_+_36914636 0.10 ENSDART00000150948
Pim proto-oncogene, serine/threonine kinase, related 205
chr12_+_30367079 0.10 ENSDART00000190112
si:ch211-225b10.4
chr14_+_22132388 0.10 ENSDART00000109065
cyclin G1
chr17_-_46817295 0.09 ENSDART00000155904
Pim proto-oncogene, serine/threonine kinase, related 24
chr9_-_49860756 0.09 ENSDART00000044270
tetratricopeptide repeat domain 21B
chr24_+_31374324 0.09 ENSDART00000172335
ENSDART00000163162
copine III
chr24_+_39576071 0.09 ENSDART00000147137
si:dkey-161j23.6
chr6_+_16895685 0.09 ENSDART00000154090
Pim proto-oncogene, serine/threonine kinase, related 28
chr6_-_16804001 0.08 ENSDART00000155398
Pim proto-oncogene, serine/threonine kinase, related 40
chr13_-_25284716 0.07 ENSDART00000039828
vinculin a
chr13_-_9335891 0.07 ENSDART00000080637

chr17_-_46933567 0.07 ENSDART00000157274
Pim proto-oncogene, serine/threonine kinase, related 25
chr19_-_12648122 0.07 ENSDART00000151184
family with sequence similarity 210, member Aa
chr17_+_11372531 0.07 ENSDART00000130975
ENSDART00000149366
translocase of inner mitochondrial membrane 9 homolog
chr2_-_22659450 0.07 ENSDART00000115025
THAP domain containing 4
chr10_+_36299541 0.07 ENSDART00000166138
odorant receptor, family G, subfamily 106, member 7
chr16_+_10841163 0.06 ENSDART00000065467
death effector domain-containing 1
chr8_-_31053872 0.06 ENSDART00000109885
small nuclear ribonucleoprotein 200 (U5)
chr6_+_16870004 0.06 ENSDART00000154794
Pim proto-oncogene, serine/threonine kinase, related 21
chr1_-_7582859 0.06 ENSDART00000110696
myxovirus (influenza) resistance B
chr11_+_18873619 0.06 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr6_-_17052116 0.06 ENSDART00000156825
Pim proto-oncogene, serine/threonine kinase, related 45
chr8_-_36618073 0.06 ENSDART00000047912
G patch domain and KOW motifs
chr9_+_18572970 0.05 ENSDART00000114860
laccase (multicopper oxidoreductase) domain containing 1
chr6_-_43677125 0.05 ENSDART00000150128
forkhead box P1b
chr10_-_8434816 0.05 ENSDART00000108643
tectonic family member 1
chr12_+_48480632 0.05 ENSDART00000158157
Rho GTPase activating protein 44
chr23_+_7518294 0.05 ENSDART00000081536
HCK proto-oncogene, Src family tyrosine kinase
chr6_-_17266221 0.05 ENSDART00000155448
Pim proto-oncogene, serine/threonine kinase, related 18
chr4_-_57572054 0.05 ENSDART00000158610
Pim proto-oncogene, serine/threonine kinase, related 168
chr1_-_23588996 0.05 ENSDART00000102600
ligand dependent nuclear receptor corepressor-like
chr4_-_1818315 0.04 ENSDART00000067433
ubiquitin-conjugating enzyme E2Nb
chr2_-_14793343 0.04 ENSDART00000132264
si:ch73-366i20.1
chr2_+_7192966 0.04 ENSDART00000142735
si:ch211-13f8.1
chr16_-_52879741 0.03 ENSDART00000166470
tubulin polymerization promoting protein
chr4_-_57571688 0.03 ENSDART00000160179
Pim proto-oncogene, serine/threonine kinase, related 168
chr25_-_30394746 0.03 ENSDART00000185346
si:ch211-93f2.1
chr24_+_13635108 0.03 ENSDART00000183008
transient receptor potential cation channel, subfamily A, member 1b
chr6_-_16735402 0.03 ENSDART00000154216
Pim proto-oncogene, serine/threonine kinase, related 44
chr7_+_33133547 0.03 ENSDART00000191967
si:ch211-194p6.7
chr21_-_38619305 0.02 ENSDART00000139178
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr3_+_49021079 0.02 ENSDART00000162012
zgc:163083
chr1_-_493218 0.02 ENSDART00000031635
excision repair cross-complementation group 5
chr7_+_17560808 0.02 ENSDART00000159699
ENSDART00000165724
ENSDART00000129017
ENSDART00000101955
novel immune-type receptor 1b
chr8_-_47212686 0.02 ENSDART00000040370
Pim proto-oncogene, serine/threonine kinase, related 189
chr17_+_12255642 0.02 ENSDART00000155175
Pim proto-oncogene, serine/threonine kinase, related 175
chr8_-_46060685 0.02 ENSDART00000121902
Pim proto-oncogene, serine/threonine kinase, related 188
chr5_-_37933983 0.02 ENSDART00000185364
sodium channel, voltage-gated, type IV, beta b
chr3_-_6608342 0.01 ENSDART00000161188
si:ch73-59f11.3
chr7_+_34786591 0.01 ENSDART00000173700
si:dkey-148a17.5
chr4_+_34599803 0.01 ENSDART00000134088
Pim proto-oncogene, serine/threonine kinase, related 168
chr12_+_22404108 0.01 ENSDART00000153055
high density lipoprotein binding protein b
chr12_+_38983989 0.01 ENSDART00000156673
si:ch73-181m17.1
chr9_+_1313418 0.01 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr20_+_48754045 0.01 ENSDART00000062578
zgc:110348
chr15_-_25083200 0.01 ENSDART00000156053
Pim proto-oncogene, serine/threonine kinase, related 191
chr25_+_34749812 0.00 ENSDART00000185712
WW domain containing E3 ubiquitin protein ligase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of stat5a+stat5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.6 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.4 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 0.3 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.1 0.2 GO:0039531 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.1 0.3 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.2 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.4 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.3 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.0 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.7 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.3 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.2 GO:0032418 lysosome localization(GO:0032418)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.1 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0 0.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.5 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.3 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.7 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.2 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.3 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 0.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.2 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.3 GO:0032052 bile acid binding(GO:0032052)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.3 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling