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PRJNA195909:zebrafish embryo and larva development
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Results for srfa+srfb
Z-value: 3.76
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Transcription factors associated with srfa+srfb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| srfa | dr11_v1_chr22_+_35089031_35089031 | -0.82 | 6.4e-03 | Click! |
| srfb | dr11_v1_chr13_-_51922290_51922290 | -0.05 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of srfa+srfb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.8 | GO:0061515 | myeloid cell development(GO:0061515) |
| 0.1 | 17.5 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 0.1 | 16.4 | GO:0061061 | muscle structure development(GO:0061061) |
| 0.4 | 15.1 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.1 | 13.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 3.7 | 11.0 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.4 | 9.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.6 | 8.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.7 | 7.2 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.8 | 7.1 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 54.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 22.3 | GO:0016459 | myosin complex(GO:0016459) |
| 1.2 | 19.9 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 9.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.4 | 8.5 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 7.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 4.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 4.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 4.4 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.7 | 3.6 | GO:0097433 | dense body(GO:0097433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 80.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 40.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.8 | 16.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.6 | 15.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.6 | 8.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 7.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 6.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 5.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.4 | 4.7 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 0.7 | 3.6 | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 4.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 4.2 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 3.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 3.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 2.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 1.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 7.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 3.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 2.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 2.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 1.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |