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PRJNA195909:zebrafish embryo and larva development

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Results for srebf2

Z-value: 0.72

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr11_v1_chr3_+_1107102_1107102-0.373.3e-01Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_19006631 1.23 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr13_-_992458 1.19 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr21_+_28445052 1.05 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr9_-_7539297 1.00 ENSDART00000081550
ENSDART00000081553
desma
desmin a
chr12_-_23009312 0.92 ENSDART00000111801
mkxa
mohawk homeobox a
chr13_-_33398735 0.82 ENSDART00000182601
ENSDART00000103628
btbd6a
BTB (POZ) domain containing 6a
chr10_-_31782616 0.77 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr18_-_21271373 0.71 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr7_+_22616212 0.68 ENSDART00000052844
cldn7a
claudin 7a
chr7_-_30082931 0.65 ENSDART00000075600
tspan3b
tetraspanin 3b
chr7_+_39401388 0.59 ENSDART00000144750
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr10_-_5053589 0.58 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr5_-_14344647 0.56 ENSDART00000188456
tet3
tet methylcytosine dioxygenase 3
chr4_+_19535946 0.53 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
lrrc4.1
leucine rich repeat containing 4.1
chr6_-_34958274 0.50 ENSDART00000113097
hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr16_+_41873708 0.46 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr23_-_20258490 0.44 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr10_-_35220285 0.43 ENSDART00000180439
ypel2a
yippee-like 2a
chr14_-_33894915 0.43 ENSDART00000143290
urp1
urotensin-related peptide 1
chr17_-_48915427 0.43 ENSDART00000054781
lgals8b
galectin 8b
chr11_+_14280598 0.42 ENSDART00000163033
si:ch211-262i1.3
si:ch211-262i1.3
chr11_-_3334248 0.42 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr24_+_9590188 0.39 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr25_-_34632050 0.39 ENSDART00000170671
megf8
multiple EGF-like-domains 8
chr19_-_10196370 0.38 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr6_-_15101477 0.37 ENSDART00000187713
ENSDART00000124132
fhl2b
four and a half LIM domains 2b
chr20_-_27311675 0.37 ENSDART00000026088
ENSDART00000148361
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr7_+_44445595 0.34 ENSDART00000108766
cdh5
cadherin 5
chr4_+_41311345 0.34 ENSDART00000151905
si:dkey-16p19.8
si:dkey-16p19.8
chr11_+_14281100 0.33 ENSDART00000193664
ENSDART00000161597
si:ch211-262i1.3
si:ch211-262i1.3
chr12_-_34459601 0.31 ENSDART00000111717
fscn2b
fascin actin-bundling protein 2b, retinal
chr9_-_4075620 0.30 ENSDART00000046903
mylka
myosin, light chain kinase a
chr6_-_15757867 0.29 ENSDART00000063665
ackr3b
atypical chemokine receptor 3b
chr2_+_24203229 0.27 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr22_-_13466246 0.24 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr14_-_30390145 0.24 ENSDART00000045423
slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr3_+_14558188 0.24 ENSDART00000143904
epor
erythropoietin receptor
chr24_-_40860603 0.23 ENSDART00000188032
CU633479.7

chr3_-_45308394 0.23 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr15_+_30157602 0.23 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr7_+_25920792 0.22 ENSDART00000026295
arrb2b
arrestin, beta 2b
chr9_-_38579758 0.22 ENSDART00000131738
si:dkey-101k6.5
si:dkey-101k6.5
chr8_+_22916536 0.22 ENSDART00000136403
cacna1fb
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr9_+_907459 0.19 ENSDART00000034850
ENSDART00000144114
dbi
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr22_-_13165186 0.19 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr1_-_30689004 0.18 ENSDART00000018827
dachc
dachshund c
chr9_+_54417141 0.18 ENSDART00000056810
drd1b
dopamine receptor D1b
chr14_-_46117345 0.18 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr22_+_17286841 0.17 ENSDART00000133176
FAM163A
si:dkey-171o17.8
chr8_+_52491436 0.17 ENSDART00000164298
si:ch1073-392o20.1
si:ch1073-392o20.1
chr5_-_36328688 0.16 ENSDART00000011399
efnb1
ephrin-B1
chr3_+_19299309 0.14 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr14_-_29826659 0.13 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr18_-_14337450 0.13 ENSDART00000061435
hsbp1b
heat shock factor binding protein 1b
chr3_-_61099004 0.11 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr3_-_34296361 0.10 ENSDART00000181485
ENSDART00000113726
tnrc6c1
trinucleotide repeat containing 6C1
chr17_+_15041647 0.10 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr5_+_37032038 0.09 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr22_-_6959769 0.09 ENSDART00000105866
si:ch73-213k20.5
si:ch73-213k20.5
chr6_+_102506 0.08 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr5_+_45976130 0.08 ENSDART00000175670
sv2c
synaptic vesicle glycoprotein 2C
chr21_-_1742159 0.07 ENSDART00000151049
onecut2
one cut homeobox 2
chr1_-_9940494 0.07 ENSDART00000138726
tmem8a
transmembrane protein 8A
chr18_+_39649825 0.06 ENSDART00000087960
gldn
gliomedin
chr18_+_8231138 0.06 ENSDART00000140193
arsa
arylsulfatase A
chr13_+_30572172 0.06 ENSDART00000010052
ENSDART00000144417
ppifa
peptidylprolyl isomerase Fa
chr5_-_12524996 0.06 ENSDART00000142258
si:ch73-263f13.1
si:ch73-263f13.1
chr2_-_48539673 0.04 ENSDART00000168202
CR391991.4

chr17_-_33552363 0.04 ENSDART00000154400
tmem121aa
transmembrane protein 121Aa
chr3_-_6417328 0.04 ENSDART00000160979
jpt1b
Jupiter microtubule associated homolog 1b
chr24_-_28229618 0.04 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr20_-_7176809 0.04 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr23_-_7674902 0.03 ENSDART00000185612
ENSDART00000180524
plagl2
pleiomorphic adenoma gene-like 2
chr16_+_25761101 0.03 ENSDART00000110619
cblc
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr11_+_21587950 0.02 ENSDART00000162251
FAM72B
zgc:101564
chr3_+_47245764 0.02 ENSDART00000193581
tnfsf14
TNF superfamily member 14
chr14_-_498979 0.02 ENSDART00000171976
spry1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr5_-_29534748 0.02 ENSDART00000159587
AL831768.1

chr22_-_8931093 0.02 ENSDART00000181813
FO393424.3

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.2 1.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.1 0.6 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1 0.3 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.1 1.2 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.4 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.3 GO:0001955 blood vessel maturation(GO:0001955) regulation of establishment of cell polarity(GO:2000114)
0.1 0.2 GO:1900136 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.1 0.9 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.2 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.2 GO:0089718 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.2 GO:0042311 vasodilation(GO:0042311)
0.0 0.4 GO:0016203 muscle attachment(GO:0016203)
0.0 0.1 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 0.2 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.0 0.2 GO:0001541 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.0 0.5 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.7 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.6 GO:0003009 skeletal muscle contraction(GO:0003009)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.4 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.2 1.1 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 0.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions