ISMARA results: spi2+spic

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PRJNA195909:zebrafish embryo and larva development

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Results for spi2+spic

Z-value: 1.48

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Transcription factors associated with spi2+spic

Gene Symbol	Gene ID	Gene Info
spic NCBI UniProt	ENSDARG00000012435	Spi-C transcription factor (Spi-1/PU.1 related)
spi2 NCBI UniProt	ENSDARG00000087438	Spi-2 proto-oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
spi2	dr11_v1_chr4_-_17803784_17803784	-0.70	3.4e-02	Click!
spic	dr11_v1_chr4_-_17812131_17812131	-0.33	3.8e-01	Click!

Activity profile of spi2+spic motif

Sorted Z-values of spi2+spic motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_38287987 Show fit	1.90	ENSDART00000185329 ENSDART00000061677	si:ch211-14a17.6 NCBI UniProt Show fit	si:ch211-14a17.6
chr4_-_17263210 Show fit	1.88	ENSDART00000147853	lrmp NCBI UniProt Show fit	lymphoid-restricted membrane protein
chr9_+_8408054 Show fit	1.80	ENSDART00000144373	zgc:153499 NCBI UniProt Show fit	zgc:153499
chr23_+_24989387 Show fit	1.80	ENSDART00000172299 ENSDART00000145307	arhgap4a NCBI UniProt Show fit	Rho GTPase activating protein 4a
chr13_+_31716820 Show fit	1.61	ENSDART00000034745	prkcha NCBI UniProt Show fit	protein kinase C, eta, a
chr12_-_33354409 Show fit	1.57	ENSDART00000178515	slc16a3 NCBI UniProt Show fit	solute carrier family 16 (monocarboxylate transporter), member 3
chr9_+_8407778 Show fit	1.50	ENSDART00000102754 ENSDART00000178144	zgc:153499 NCBI UniProt Show fit	zgc:153499
chr12_+_13091842 Show fit	1.41	ENSDART00000185477 ENSDART00000181435 ENSDART00000124799	si:ch211-103b1.2 NCBI UniProt Show fit	si:ch211-103b1.2
chr15_+_34939906 Show fit	1.32	ENSDART00000131182	si:ch73-95l15.3 NCBI UniProt Show fit	si:ch73-95l15.3
chr9_-_35633827 Show fit	1.32	ENSDART00000077745	zp2l1 NCBI UniProt Show fit	zona pellucida glycoprotein 2, like 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of spi2+spic

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.1	2.0	GO:0045851	vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.6	1.9	GO:0035046	pronuclear migration(GO:0035046)
0.1	1.9	GO:0035803	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0	1.8	GO:0030336	negative regulation of cell migration(GO:0030336)
0.1	1.7	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	1.5	GO:0099518	vesicle cytoskeletal trafficking(GO:0099518)
0.3	1.4	GO:0033301	cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.1	1.4	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	1.3	GO:0090630	activation of GTPase activity(GO:0090630)

Showing 1 to 10 of 214 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.7	GO:0005764	lysosome(GO:0005764)
0.2	2.0	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2	2.0	GO:0097431	mitotic spindle pole(GO:0097431)
0.1	1.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	1.7	GO:0005871	kinesin complex(GO:0005871)
0.0	1.7	GO:0031201	SNARE complex(GO:0031201)
0.0	1.5	GO:0005802	trans-Golgi network(GO:0005802)
0.0	1.4	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.2	1.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	1.2	GO:0005685	U1 snRNP(GO:0005685)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0030695	GTPase regulator activity(GO:0030695)
0.0	2.5	GO:0030246	carbohydrate binding(GO:0030246)
0.1	2.1	GO:0031267	small GTPase binding(GO:0031267)
0.0	2.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	1.9	GO:0032190	acrosin binding(GO:0032190)
0.1	1.9	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	1.8	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	1.7	GO:0003777	microtubule motor activity(GO:0003777)
0.0	1.7	GO:1901981	phosphatidylinositol phosphate binding(GO:1901981)
0.0	1.7	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 158 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.3	PID P73PATHWAY	p73 transcription factor network
0.1	1.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	1.1	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	1.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.9	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.9	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	0.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.1	0.8	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.8	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	1.5	REACTOME TRANSCRIPTION	Genes involved in Transcription
0.1	1.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	1.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	1.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.1	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	1.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.0	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	1.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus

Showing 1 to 10 of 62 entries

Results for spi2+spic

Z-value: 1.48

Motif logo

Transcription factors associated with spi2+spic

Activity-expression correlation:

Activity profile of spi2+spic motif

Sorted Z-values of spi2+spic motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of spi2+spic

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: