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PRJNA195909:zebrafish embryo and larva development
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Results for sp2
Z-value: 2.04
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Transcription factors associated with sp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sp2 | dr11_v1_chr11_-_12008001_12008001 | 0.91 | 7.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_33991801 Show fit | 5.55 |
ENSDART00000061744
|
zona pellucida glycoprotein 3a, tandem duplicate 1 |
|
| chr17_-_2584423 Show fit | 5.04 |
ENSDART00000013506
|
zona pellucida glycoprotein 3, tandem duplicate 2 |
|
| chr20_+_33987465 Show fit | 4.94 |
ENSDART00000061751
|
zona pellucida glycoprotein 3a, tandem duplicate 2 |
|
| chr24_-_20599781 Show fit | 4.76 |
ENSDART00000179664
ENSDART00000141823 |
zinc finger and BTB domain containing 47b |
|
| chr22_+_835728 Show fit | 4.05 |
ENSDART00000003325
|
DENN/MADD domain containing 2Db |
|
| chr18_-_127558 Show fit | 3.47 |
ENSDART00000149556
|
transient receptor potential cation channel, subfamily M, member 7 |
|
| chr20_+_54304800 Show fit | 3.38 |
ENSDART00000121661
|
zona pellucida glycoprotein 2, tandem duplicate 6 |
|
| chr13_-_17860307 Show fit | 3.03 |
ENSDART00000135920
ENSDART00000054579 |
membrane-associated ring finger (C3HC4) 8 |
|
| chr25_+_22319940 Show fit | 2.97 |
ENSDART00000154065
ENSDART00000153492 ENSDART00000024866 ENSDART00000154376 |
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr10_-_641609 Show fit | 2.89 |
ENSDART00000041236
|
regulatory factor X, 3 (influences HLA class II expression) |
Network of associatons between targets according to the STRING database.
First level regulatory network of sp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 15.5 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 1.9 | 5.8 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.5 | 4.1 | GO:0016121 | carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247) |
| 0.2 | 3.7 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 3.7 | GO:0060027 | convergent extension involved in gastrulation(GO:0060027) |
| 0.3 | 3.5 | GO:0090309 | methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 3.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.8 | 3.0 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.6 | 3.0 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 3.0 | GO:0032402 | melanosome transport(GO:0032402) pigment granule transport(GO:0051904) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 5.2 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 4.0 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 3.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 2.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 2.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 2.7 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.4 | 2.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 2.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 2.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.5 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 9.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.5 | 6.5 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.0 | 6.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.5 | 4.1 | GO:0003834 | beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436) |
| 0.0 | 4.0 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 3.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 3.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 3.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.0 | 3.0 | GO:0016713 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 3.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 2.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 2.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 2.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 1.5 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.0 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 3.0 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 2.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 2.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 2.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.3 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.5 | 2.1 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.4 | 1.8 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 1.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |