ISMARA results: sp1

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PRJNA195909:zebrafish embryo and larva development

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Results for sp1

Z-value: 1.25

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Transcription factors associated with sp1

Gene Symbol	Gene ID	Gene Info
sp1 NCBI UniProt	ENSDARG00000088347	sp1 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp1	dr11_v1_chr11_-_28224_28224	0.56	1.1e-01	Click!

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_1625080 Show fit	1.31	ENSDART00000137285	nup155 NCBI UniProt Show fit	nucleoporin 155
chr13_+_45582391 Show fit	1.25	ENSDART00000058093	ldlrap1b NCBI UniProt Show fit	low density lipoprotein receptor adaptor protein 1b
chr3_+_1211242 Show fit	1.24	ENSDART00000171287 ENSDART00000165769	poldip3 NCBI UniProt Show fit	polymerase (DNA-directed), delta interacting protein 3
chr17_-_2584423 Show fit	1.16	ENSDART00000013506	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr21_-_5056812 Show fit	0.96	ENSDART00000139713 ENSDART00000140859	zgc:77838 NCBI UniProt Show fit	zgc:77838
chr16_-_29387215 Show fit	0.89	ENSDART00000148787	s100a1 NCBI UniProt Show fit	S100 calcium binding protein A1
chr21_-_11646878 Show fit	0.87	ENSDART00000162426 ENSDART00000135937 ENSDART00000131448 ENSDART00000148097 ENSDART00000133443	cast NCBI UniProt Show fit	calpastatin
chr13_-_17860307 Show fit	0.87	ENSDART00000135920 ENSDART00000054579	march8 NCBI UniProt Show fit	membrane-associated ring finger (C3HC4) 8
chr12_+_46634736 Show fit	0.87	ENSDART00000008009	trim16 NCBI UniProt Show fit	tripartite motif containing 16
chr10_+_8629275 Show fit	0.87	ENSDART00000129643	aplnrb NCBI UniProt Show fit	apelin receptor b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	GO:0060046	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.4	1.3	GO:0090435	protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1	1.2	GO:0090308	methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	1.2	GO:0030048	actin filament-based movement(GO:0030048)
0.1	1.1	GO:0046626	regulation of insulin receptor signaling pathway(GO:0046626)
0.1	1.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	1.1	GO:0016575	histone deacetylation(GO:0016575)
0.0	1.0	GO:0036297	interstrand cross-link repair(GO:0036297)
0.3	0.9	GO:0060959	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.3	0.9	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)

Showing 1 to 10 of 276 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0000785	chromatin(GO:0000785)
0.0	1.8	GO:0031902	late endosome membrane(GO:0031902)
0.0	1.7	GO:0016459	myosin complex(GO:0016459)
0.1	1.5	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1	1.5	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	1.5	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	1.5	GO:0055037	recycling endosome(GO:0055037)
0.0	1.4	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	1.4	GO:0005769	early endosome(GO:0005769)
0.3	1.3	GO:0044611	nuclear pore inner ring(GO:0044611)

Showing 1 to 10 of 88 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.4	GO:0035804	structural constituent of egg coat(GO:0035804)
0.2	1.7	GO:0001217	bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1	1.6	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	1.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	1.2	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	1.0	GO:0015299	solute:proton antiporter activity(GO:0015299)
0.0	1.0	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	1.0	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2	0.9	GO:0060182	apelin receptor activity(GO:0060182)
0.1	0.9	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Showing 1 to 10 of 167 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	1.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	1.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.0	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.9	PID P73PATHWAY	p73 transcription factor network
0.0	0.7	PID FOXO PATHWAY	FoxO family signaling
0.0	0.7	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	1.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.3	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.1	1.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	1.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	1.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	1.1	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.1	0.9	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	0.7	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide

Showing 1 to 10 of 53 entries

Results for sp1

Z-value: 1.25

Motif logo

Transcription factors associated with sp1

Activity-expression correlation:

Activity profile of sp1 motif

Sorted Z-values of sp1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: