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PRJNA195909:zebrafish embryo and larva development

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Results for sox8a+sox8b

Z-value: 0.94

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Transcription factors associated with sox8a+sox8b

Gene Symbol Gene ID Gene Info
ENSDARG00000037782 SRY-box transcription factor 8b
ENSDARG00000105301 SRY-box transcription factor 8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox8adr11_v1_chr12_-_1085227_1085227-0.853.9e-03Click!
sox8bdr11_v1_chr3_-_62403550_624035500.137.4e-01Click!

Activity profile of sox8a+sox8b motif

Sorted Z-values of sox8a+sox8b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_50001606 2.08 ENSDART00000161648
ENSDART00000168514
sodium channel, voltage-gated, type I, alpha
chr17_-_33707589 1.82 ENSDART00000124788
si:dkey-84k17.2
chr3_-_3413669 1.65 ENSDART00000113517
ENSDART00000179861
ENSDART00000115331
zgc:171446
chr20_-_39789036 1.43 ENSDART00000086405
ENSDART00000098253
ring finger protein 217
chr3_-_5067585 1.31 ENSDART00000169609
thyrotrophic embryonic factor b
chr13_+_8892784 1.27 ENSDART00000075054
ENSDART00000143705
thyroid adenoma associated
chr9_+_50001746 1.23 ENSDART00000058892
solute carrier family 38, member 11
chr12_-_33359052 1.22 ENSDART00000135943
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_-_33359654 1.19 ENSDART00000001907
solute carrier family 16 (monocarboxylate transporter), member 3
chr19_-_27448606 1.08 ENSDART00000079251
valyl-tRNA synthetase 2, mitochondrial (putative)
chr1_-_23308225 1.06 ENSDART00000137567
ENSDART00000008201
small integral membrane protein 14
chr9_+_34952203 1.03 ENSDART00000121828
ENSDART00000142347
transcription factor Dp-1, a
chr19_+_27448625 0.97 ENSDART00000052352
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr24_-_41220538 0.95 ENSDART00000150207
activin A receptor type 2Ba
chr8_+_10862353 0.94 ENSDART00000140717
bromodomain and PHD finger containing, 3b
chr11_+_30254556 0.91 ENSDART00000182316
protein phosphatase, EF-hand calcium binding domain 1
chr5_+_45139196 0.89 ENSDART00000113738
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_+_11432330 0.85 ENSDART00000188065
PQ loop repeat containing 1
chr21_+_39673157 0.84 ENSDART00000100240
mitochondrial rRNA methyltransferase 3b
chr6_-_37743724 0.81 ENSDART00000149068
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr21_+_42717424 0.80 ENSDART00000166936
ENSDART00000172135
SH3 and PX domains 2B
chr8_-_7603516 0.77 ENSDART00000179826
ENSDART00000190153
interleukin-1 receptor-associated kinase 1
chr10_+_5268054 0.76 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr25_-_37248795 0.75 ENSDART00000087247
ENSDART00000154045
golgi glycoprotein 1a
chr3_+_32663865 0.75 ENSDART00000190240
si:dkey-16l2.16
chr22_-_547748 0.74 ENSDART00000037455
ENSDART00000140101
cyclin D3
chr7_+_52753067 0.72 ENSDART00000053814
mitochondrial methionyl-tRNA formyltransferase
chr11_+_13176568 0.71 ENSDART00000125371
ENSDART00000123257
MAP kinase interacting serine/threonine kinase 1
chr9_-_8979468 0.70 ENSDART00000134646
inhibitor of growth family, member 1
chr5_+_45138934 0.70 ENSDART00000041412
ENSDART00000136002
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_24770435 0.70 ENSDART00000078854
MPV17 mitochondrial membrane protein-like 2
chr12_-_11593436 0.69 ENSDART00000138954
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr25_+_4787431 0.69 ENSDART00000170640
myosin VC
chr16_-_21047483 0.68 ENSDART00000136235
chromobox homolog 3b
chr8_-_7603700 0.68 ENSDART00000137975
interleukin-1 receptor-associated kinase 1
chr10_+_9595575 0.66 ENSDART00000091780
ENSDART00000184287
ring finger and CCCH-type domains 2
chr11_-_18015534 0.64 ENSDART00000181953
glutamine-rich 1
chr3_+_41726360 0.62 ENSDART00000154401
carbohydrate (chondroitin 4) sulfotransferase 12a
chr13_-_8892514 0.61 ENSDART00000144553
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr25_+_4787607 0.61 ENSDART00000159422
myosin VC
chr9_-_3934963 0.60 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr4_+_6833735 0.60 ENSDART00000136355
dedicator of cytokinesis 4b
chr21_+_34088377 0.60 ENSDART00000170070
myotubularin related protein 1b
chr22_+_9522971 0.60 ENSDART00000110048
striatin interacting protein 1
chr21_+_43328685 0.59 ENSDART00000109620
ENSDART00000139668
septin 8a
chr7_+_25003851 0.58 ENSDART00000144526
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr3_-_59981162 0.57 ENSDART00000128790
cerebellar degeneration-related protein 2-like
chr2_+_23222939 0.57 ENSDART00000026800
kinesin-associated protein 3b
chr15_+_3125136 0.55 ENSDART00000130968
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr8_+_42718135 0.55 ENSDART00000158900
zgc:194007
chr2_+_15048410 0.52 ENSDART00000058484
calponin 3, acidic b
chr18_+_45666489 0.51 ENSDART00000180147
ENSDART00000151351
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr2_+_29925561 0.50 ENSDART00000163118
ENSDART00000183800
ENSDART00000180738
ENSDART00000139604
5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a
chr3_+_62327332 0.48 ENSDART00000158414

chr21_+_34088110 0.47 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr18_+_5917625 0.47 ENSDART00000169100
golgi glycoprotein 1b
chr19_-_11950434 0.45 ENSDART00000024861
cleavage and polyadenylation specific factor 1
chr19_-_11949996 0.44 ENSDART00000163478
ENSDART00000167299
cleavage and polyadenylation specific factor 1
chr23_-_36418708 0.44 ENSDART00000132273
zinc finger protein 740b
chr20_-_3276339 0.43 ENSDART00000166831
ribosomal protein S6 kinase polypeptide 1
chr16_+_46410520 0.42 ENSDART00000131072
rapunzel 2
chr22_-_817479 0.41 ENSDART00000123487
zgc:153675
chr6_+_7322587 0.40 ENSDART00000065500
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr11_-_43226255 0.40 ENSDART00000172929
spectrin, beta, non-erythrocytic 1
chr2_-_22492289 0.40 ENSDART00000168022
general transcription factor IIB
chr10_+_15967643 0.38 ENSDART00000136709
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr7_+_65121743 0.36 ENSDART00000108471
importin 7
chr12_+_34258139 0.36 ENSDART00000153127
suppressor of cytokine signaling 3b
chr10_-_7386475 0.36 ENSDART00000167963
neuregulin 1
chr9_-_8979154 0.34 ENSDART00000145266
inhibitor of growth family, member 1
chr4_+_6833583 0.34 ENSDART00000165179
ENSDART00000186134
ENSDART00000174507
dedicator of cytokinesis 4b
chr11_-_2478374 0.33 ENSDART00000173205
si:ch73-267c23.10
chr5_-_6567464 0.32 ENSDART00000184985
tankyrase 1 binding protein 1
chr17_+_24604373 0.32 ENSDART00000082193
zinc metallopeptidase, STE24 homolog
chr9_-_43538328 0.32 ENSDART00000140526
zinc finger protein 385B
chr5_+_31214341 0.32 ENSDART00000133432
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr10_+_11398111 0.29 ENSDART00000064210
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr7_+_17096281 0.28 ENSDART00000035558
HIV-1 Tat interactive protein 2
chr3_+_39579393 0.28 ENSDART00000055170
ceroid-lipofuscinosis, neuronal 3
chr3_-_59981476 0.28 ENSDART00000035878
ENSDART00000124038
cerebellar degeneration-related protein 2-like
chr15_-_9419472 0.27 ENSDART00000122117
sacsin molecular chaperone
chr16_-_21047872 0.26 ENSDART00000131582
chromobox homolog 3b
chr24_-_3304664 0.24 ENSDART00000183168
succinyl-CoA:glutarate-CoA transferase
chr20_+_25936370 0.22 ENSDART00000141265
zinc finger protein 106b
chr19_-_9648542 0.21 ENSDART00000172628
chloride channel, voltage-sensitive 1a
chr20_-_39391833 0.20 ENSDART00000135149
si:dkey-217m5.8
chr5_+_41146786 0.20 ENSDART00000175766
SUB1 homolog, transcriptional regulator b
chr1_+_6646529 0.18 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ubiquitin-conjugating enzyme E2F (putative)
chr14_+_31721171 0.18 ENSDART00000173034
adhesion G protein-coupled receptor G4a
chr10_+_7709724 0.16 ENSDART00000097670
gamma-glutamyl carboxylase
chr20_-_39391492 0.16 ENSDART00000184886
si:dkey-217m5.8
chr8_-_46386024 0.14 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
glutaminyl-tRNA synthetase
chr22_+_38301365 0.13 ENSDART00000137339
Tnf receptor-associated factor 5
chr9_+_17423941 0.13 ENSDART00000112884
ENSDART00000155233
kelch repeat and BTB (POZ) domain containing 7
chr22_+_24673168 0.13 ENSDART00000135257
si:rp71-23d18.8
chr12_+_18544159 0.12 ENSDART00000162900
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr2_+_51645164 0.10 ENSDART00000169600
abhydrolase domain containing 4
chr9_-_3034064 0.08 ENSDART00000115138
ENSDART00000144046
Rap guanine nucleotide exchange factor (GEF) 4
chr19_-_17208728 0.06 ENSDART00000151228
stathmin 1a
chr24_-_33873451 0.04 ENSDART00000159840
acid-sensing (proton-gated) ion channel 1c
chr19_-_24198139 0.03 ENSDART00000138864
ENSDART00000125350
perforin 1.7
chr1_-_16688965 0.03 ENSDART00000079001
ENSDART00000178599
FSHD region gene 1
chr10_-_14545658 0.02 ENSDART00000057865
immediate early response 3 interacting protein 1
chr10_-_22249444 0.00 ENSDART00000148831
fibroblast growth factor 11b

Network of associatons between targets according to the STRING database.

First level regulatory network of sox8a+sox8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 0.7 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 1.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.8 GO:0071800 podosome assembly(GO:0071800)
0.1 1.0 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1 0.3 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 0.9 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 1.3 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.3 GO:0015809 arginine transport(GO:0015809)
0.0 0.9 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 2.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.2 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 1.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.3 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.4 GO:0098754 detoxification(GO:0098754)
0.0 1.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.0 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 1.3 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 0.9 GO:0050906 detection of stimulus involved in sensory perception(GO:0050906)
0.0 0.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.1 1.0 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.8 GO:0002102 podosome(GO:0002102)
0.1 0.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.9 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 1.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.6 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.6 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 1.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 1.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.7 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.9 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 0.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.1 1.0 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 1.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.2 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.8 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 2.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling