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PRJNA195909:zebrafish embryo and larva development
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Results for sox5
Z-value: 2.06
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Transcription factors associated with sox5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sox5 | dr11_v1_chr4_-_17055950_17055950 | 0.96 | 3.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of sox5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 6.6 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 6.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.8 | 5.3 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.2 | 4.8 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 4.0 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 4.0 | GO:0051216 | cartilage development(GO:0051216) |
| 0.1 | 3.8 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 1.2 | 3.7 | GO:0005985 | sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351) |
| 0.1 | 3.3 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 6.4 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 4.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 3.7 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.0 | 2.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 2.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.3 | 2.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.2 | GO:0001159 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.2 | 14.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 6.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 6.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.3 | 6.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 5.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 4.6 | GO:0031013 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.0 | 4.4 | GO:0003779 | actin binding(GO:0003779) |
| 1.2 | 3.7 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.7 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 2.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 0.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 2.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 2.4 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 2.0 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 1.8 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 1.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |