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PRJNA195909:zebrafish embryo and larva development

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Results for sox1a+sox1b

Z-value: 1.07

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Transcription factors associated with sox1a+sox1b

Gene Symbol Gene ID Gene Info
sox1b
ENSDARG00000008131 SRY-box transcription factor 1b
sox1a
ENSDARG00000069866 SRY-box transcription factor 1a
sox1a
ENSDARG00000110682 SRY-box transcription factor 1a
sox1a
ENSDARG00000114571 SRY-box transcription factor 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox1bdr11_v1_chr1_+_46194333_461943330.964.9e-05Click!
sox1adr11_v1_chr9_+_21722733_217227330.925.3e-04Click!

Activity profile of sox1a+sox1b motif

Sorted Z-values of sox1a+sox1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_9421510 3.83 ENSDART00000123652
hmgn6
high mobility group nucleosome binding domain 6
chr19_-_41472228 3.08 ENSDART00000113388
dlx5a
distal-less homeobox 5a
chr23_+_31815423 3.06 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr1_-_31856622 2.50 ENSDART00000065125
nt5c2b
5'-nucleotidase, cytosolic IIb
chr14_-_9420911 2.04 ENSDART00000081158
sh3bgrl
SH3 domain binding glutamate-rich protein like
chr18_-_23874929 1.67 ENSDART00000134910
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr1_+_51479128 1.61 ENSDART00000028018
meis1a
Meis homeobox 1 a
chr20_-_40370736 1.41 ENSDART00000041229
fabp7b
fatty acid binding protein 7, brain, b
chr12_+_26512569 1.33 ENSDART00000066264
chad
chondroadherin
chr18_-_23875219 1.20 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr2_+_7715810 0.92 ENSDART00000130781
eif4a2
eukaryotic translation initiation factor 4A, isoform 2
chr12_+_30168342 0.89 ENSDART00000142756
ablim1b
actin binding LIM protein 1b
chr7_+_61480296 0.84 ENSDART00000083255
adam19a
ADAM metallopeptidase domain 19a
chr14_-_17072736 0.84 ENSDART00000106333
phox2bb
paired-like homeobox 2bb
chr16_-_50181206 0.81 ENSDART00000148478
lim2.5
lens intrinsic membrane protein 2.5
chr19_+_11978209 0.81 ENSDART00000111568
polr2k
polymerase (RNA) II (DNA directed) polypeptide K
chr23_+_17800717 0.81 ENSDART00000122654
ENSDART00000044986
rnd1a
Rho family GTPase 1a
chr14_+_45883687 0.76 ENSDART00000114790
flrt1b
fibronectin leucine rich transmembrane protein 1b
chr18_-_81280 0.74 ENSDART00000149810
ENSDART00000149321
hdc
histidine decarboxylase
chr14_+_36886950 0.73 ENSDART00000183719
si:ch211-132p1.3
si:ch211-132p1.3
chr2_-_53481912 0.70 ENSDART00000189610
hsd11b1lb
hydroxysteroid (11-beta) dehydrogenase 1-like b
chr17_-_37054959 0.64 ENSDART00000151921
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr16_-_8927425 0.62 ENSDART00000000382
triob
trio Rho guanine nucleotide exchange factor b
chr19_+_18758014 0.62 ENSDART00000158935
clic1
chloride intracellular channel 1
chr5_-_47727819 0.61 ENSDART00000165249
cox7c
cytochrome c oxidase, subunit VIIc
chr7_-_47148440 0.58 ENSDART00000185435
ENSDART00000189719
BX005073.3

chr9_+_2333927 0.55 ENSDART00000123340
atp5mc3a
ATP synthase membrane subunit c locus 3a
chr22_+_10010292 0.48 ENSDART00000180096
BX324216.4

chr24_+_35881984 0.47 ENSDART00000066587
klhl14
kelch-like family member 14
chr11_+_37612672 0.45 ENSDART00000157993
hp1bp3
heterochromatin protein 1, binding protein 3
chr7_+_57677120 0.44 ENSDART00000110623
arsj
arylsulfatase family, member J
chr24_-_9291857 0.41 ENSDART00000149875
tgif1
TGFB-induced factor homeobox 1
chr12_-_4598237 0.41 ENSDART00000152489
irf3
interferon regulatory factor 3
chrM_+_6425 0.40 ENSDART00000093606
mt-co1
cytochrome c oxidase I, mitochondrial
chr20_-_23852174 0.39 ENSDART00000122414
si:dkey-15j16.6
si:dkey-15j16.6
chr23_-_44233408 0.38 ENSDART00000149318
ENSDART00000085528
zgc:158659
zgc:158659
chr1_+_25732715 0.37 ENSDART00000140172
npy2r
neuropeptide Y receptor Y2
chr10_-_34889053 0.36 ENSDART00000136966
ccdc169
coiled-coil domain containing 169
chr14_-_3229384 0.34 ENSDART00000167247
pdgfrb
platelet-derived growth factor receptor, beta polypeptide
chr15_-_951118 0.34 ENSDART00000171427
alox5b.1
arachidonate 5-lipoxygenase b, tandem duplicate 1
chr8_+_28065803 0.33 ENSDART00000178481
kcnd3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr11_+_37612214 0.31 ENSDART00000172899
ENSDART00000077496
hp1bp3
heterochromatin protein 1, binding protein 3
chr18_-_6766354 0.31 ENSDART00000132611
adm2b
adrenomedullin 2b
chr15_-_35410860 0.30 ENSDART00000191267
mecom
MDS1 and EVI1 complex locus
chr23_+_6926183 0.28 ENSDART00000149882
si:ch211-117c9.1
si:ch211-117c9.1
chr15_-_2493771 0.25 ENSDART00000184906
neu4
sialidase 4
chr7_+_1383027 0.24 ENSDART00000143762
khnyn
KH and NYN domain containing
chr9_-_6624663 0.24 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr18_-_4958883 0.23 ENSDART00000143614
zbbx
zinc finger, B-box domain containing
chr5_+_51833132 0.20 ENSDART00000167491
papd4
PAP associated domain containing 4
chr2_+_1881334 0.18 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr10_+_25726694 0.17 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr18_-_41754020 0.15 ENSDART00000077898
grk7b
G protein-coupled receptor kinase 7b
chr11_+_33284837 0.14 ENSDART00000166239
ENSDART00000111412
nkpd1
NTPase, KAP family P-loop domain containing 1
chr5_+_51833305 0.12 ENSDART00000165276
ENSDART00000166443
papd4
PAP associated domain containing 4
chr19_+_9533008 0.12 ENSDART00000104607
fam131ba
family with sequence similarity 131, member Ba
chr19_+_23301050 0.10 ENSDART00000193713
si:dkey-79i2.4
si:dkey-79i2.4
chr22_-_8931093 0.09 ENSDART00000181813
FO393424.3

chr11_-_45434959 0.09 ENSDART00000173106
ENSDART00000172767
ENSDART00000172933
ENSDART00000172986
rfc4
replication factor C (activator 1) 4
chr19_-_11977783 0.08 ENSDART00000183337
si:ch1073-296d18.1
si:ch1073-296d18.1
chr25_-_19661198 0.07 ENSDART00000149641
atp2b1b
ATPase plasma membrane Ca2+ transporting 1b
chr11_+_16216909 0.06 ENSDART00000081035
ENSDART00000147190
slc25a26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr2_-_54039293 0.06 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr7_-_71331499 0.06 ENSDART00000081245
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr7_-_71331690 0.05 ENSDART00000149682
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr8_-_436137 0.02 ENSDART00000187021
CABZ01063543.1

chr7_+_50796422 0.01 ENSDART00000123868
dthd1
death domain containing 1
chr22_+_9994833 0.01 ENSDART00000172696
ENSDART00000192101
BX324216.1

Network of associatons between targets according to the STRING database.

First level regulatory network of sox1a+sox1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.5 3.1 GO:0045658 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.4 3.1 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2 0.7 GO:0001692 histamine metabolic process(GO:0001692)
0.2 0.8 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 0.3 GO:0071435 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.1 0.3 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.1 0.4 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 0.3 GO:0014909 smooth muscle cell migration(GO:0014909)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.3 GO:0019372 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.7 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.4 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.6 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.3 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.6 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 7.1 GO:0000785 chromatin(GO:0000785)
0.0 0.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 GO:0001972 retinoic acid binding(GO:0001972)
0.2 3.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.3 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 1.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.8 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 3.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism