ISMARA results: sox19b+sox3

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PRJNA195909:zebrafish embryo and larva development

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Results for sox19b+sox3

Z-value: 3.41

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Transcription factors associated with sox19b+sox3

Gene Symbol	Gene ID	Gene Info
sox19b NCBI UniProt	ENSDARG00000040266	SRY-box transcription factor 19b
sox3 NCBI UniProt	ENSDARG00000053569	SRY-box transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox19b	dr11_v1_chr7_-_26497947_26497947	-0.98	5.4e-06	Click!
sox3	dr11_v1_chr14_-_32744464_32744464	0.67	4.8e-02	Click!

Activity profile of sox19b+sox3 motif

Sorted Z-values of sox19b+sox3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_44042033 Show fit	11.09	ENSDART00000190006 ENSDART00000046172	cryba4 NCBI UniProt Show fit	crystallin, beta A4
chr10_+_33171501 Show fit	9.92	ENSDART00000159666	myl10 NCBI UniProt Show fit	myosin, light chain 10, regulatory
chr24_-_40668208 Show fit	6.35	ENSDART00000171543	smyhc1 NCBI UniProt Show fit	slow myosin heavy chain 1
chr9_-_22182396 Show fit	6.02	ENSDART00000101809	crygm2d6 NCBI UniProt Show fit	crystallin, gamma M2d6
chr6_+_52804267 Show fit	5.87	ENSDART00000065681	matn4 NCBI UniProt Show fit	matrilin 4
chr14_-_36378494 Show fit	5.80	ENSDART00000058503	gpm6aa NCBI UniProt Show fit	glycoprotein M6Aa
chr1_-_49498116 Show fit	5.39	ENSDART00000137357	zgc:175214 NCBI UniProt Show fit	zgc:175214
chr9_-_22232902 Show fit	5.35	ENSDART00000101845	crygm2d5 NCBI UniProt Show fit	crystallin, gamma M2d5
chr9_-_22318511 Show fit	5.33	ENSDART00000129295	crygm2d2 NCBI UniProt Show fit	crystallin, gamma M2d2
chr13_+_22675802 Show fit	5.22	ENSDART00000145538 ENSDART00000143312	zgc:193505 NCBI UniProt Show fit	zgc:193505

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox19b+sox3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	79.7	GO:0002088	lens development in camera-type eye(GO:0002088)
0.1	33.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3	13.8	GO:0003009	skeletal muscle contraction(GO:0003009)
2.3	9.3	GO:0016109	tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.4	8.2	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	7.6	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.6	6.7	GO:0006267	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7	6.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.4	6.5	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208)
0.4	5.7	GO:0051764	actin crosslink formation(GO:0051764)

Showing 1 to 10 of 224 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	19.3	GO:0005861	troponin complex(GO:0005861)
0.0	12.0	GO:0031012	extracellular matrix(GO:0031012)
0.1	7.8	GO:0005882	intermediate filament(GO:0005882)
0.6	7.0	GO:0044295	axonal growth cone(GO:0044295)
0.4	6.7	GO:0042555	MCM complex(GO:0042555)
0.0	6.7	GO:0005874	microtubule(GO:0005874)
0.9	6.6	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	6.0	GO:0005581	collagen trimer(GO:0005581)
0.1	5.8	GO:0016459	myosin complex(GO:0016459)
1.3	5.3	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	77.1	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	70.2	GO:0005509	calcium ion binding(GO:0005509)
0.0	60.6	GO:0000987	core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	17.8	GO:0051015	actin filament binding(GO:0051015)
0.6	10.9	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
2.3	9.3	GO:0050251	retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.1	8.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.5	7.9	GO:0005504	fatty acid binding(GO:0005504)
0.6	6.7	GO:0030172	troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2	6.6	GO:0005540	hyaluronic acid binding(GO:0005540)

Showing 1 to 10 of 160 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	6.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	4.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	3.7	PID E2F PATHWAY	E2F transcription factor network
0.2	3.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	3.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	2.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	2.6	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	2.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	2.3	PID PTP1B PATHWAY	Signaling events mediated by PTP1B

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.7	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	5.3	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.3	5.2	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.4	4.8	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.6	2.9	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.8	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	2.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	2.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.3	2.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	2.3	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Showing 1 to 10 of 45 entries

Results for sox19b+sox3

Z-value: 3.41

Motif logo

Transcription factors associated with sox19b+sox3

Activity-expression correlation:

Activity profile of sox19b+sox3 motif

Sorted Z-values of sox19b+sox3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox19b+sox3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: