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PRJNA195909:zebrafish embryo and larva development
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Results for snai1a
Z-value: 3.50
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Transcription factors associated with snai1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| snai1a | dr11_v1_chr11_-_25257595_25257595 | 0.03 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_907266 Show fit | 5.35 |
ENSDART00000171729
|
pyruvate kinase M1/2a |
|
| chr23_+_553396 Show fit | 4.36 |
ENSDART00000034707
|
LSM family member 14B |
|
| chr7_+_67699178 Show fit | 4.13 |
ENSDART00000160086
|
zgc:162592 |
|
| chr22_+_17828267 Show fit | 3.91 |
ENSDART00000136016
|
hyaluronan and proteoglycan link protein 4 |
|
| chr12_-_4301234 Show fit | 3.82 |
ENSDART00000152377
ENSDART00000152521 |
carbonic anhydrase XVb |
|
| chr5_-_15494164 Show fit | 3.81 |
ENSDART00000140668
ENSDART00000188076 ENSDART00000085943 |
TAO kinase 3a |
|
| chr6_+_40523370 Show fit | 3.38 |
ENSDART00000033819
|
protein kinase C, delta a |
|
| chr23_+_2728095 Show fit | 3.24 |
ENSDART00000066086
|
zgc:114123 |
|
| chr7_-_55648336 Show fit | 3.24 |
ENSDART00000147792
ENSDART00000135304 ENSDART00000131923 |
poly(A) binding protein, nuclear 1-like (cytoplasmic) |
|
| chr1_+_2712956 Show fit | 3.23 |
ENSDART00000126093
|
glypican 6a |
Network of associatons between targets according to the STRING database.
First level regulatory network of snai1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.9 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.8 | 13.4 | GO:0060046 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 12.2 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.1 | 8.6 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.1 | 8.4 | GO:0032147 | activation of protein kinase activity(GO:0032147) |
| 0.1 | 7.1 | GO:0051494 | negative regulation of cytoskeleton organization(GO:0051494) |
| 0.1 | 6.4 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 6.3 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.2 | 6.2 | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880) |
| 0.3 | 6.0 | GO:0007032 | endosome organization(GO:0007032) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 15.3 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 12.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 10.9 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 7.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 7.5 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 7.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.4 | 6.9 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.2 | 6.8 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.1 | 6.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 16.6 | GO:0016773 | phosphotransferase activity, alcohol group as acceptor(GO:0016773) |
| 0.8 | 13.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 13.2 | GO:0008092 | cytoskeletal protein binding(GO:0008092) |
| 0.0 | 12.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 11.0 | GO:0004697 | protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) |
| 0.0 | 10.3 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 10.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 7.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.9 | 7.2 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 6.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 4.5 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 4.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 3.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.4 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 2.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 2.3 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 4.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 4.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 4.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 4.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.3 | 4.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 4.0 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 3.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 3.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |