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PRJNA195909:zebrafish embryo and larva development
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Results for smarcc1a+smarcc1b
Z-value: 1.25
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Transcription factors associated with smarcc1a+smarcc1b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017397 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a | |
| ENSDARG00000098919 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| smarcc1b | dr11_v1_chr19_-_19379084_19379084 | -0.91 | 6.2e-04 | Click! |
| smarcc1a | dr11_v1_chr16_-_42461263_42461263 | -0.68 | 4.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_59252973 Show fit | 7.79 |
ENSDART00000167061
|
si:ch1073-286c18.5 |
|
| chr11_-_24681292 Show fit | 2.49 |
ENSDART00000089601
|
olfactomedin-like 3b |
|
| chr22_-_15593824 Show fit | 2.45 |
ENSDART00000123125
|
tropomyosin 4a |
|
| chr5_-_67471375 Show fit | 2.12 |
ENSDART00000147009
|
si:dkey-251i10.2 |
|
| chr13_+_4671698 Show fit | 2.08 |
ENSDART00000164617
ENSDART00000128494 ENSDART00000165776 |
phospholipase A2, group XIIB |
|
| chr12_-_30841679 Show fit | 2.07 |
ENSDART00000105594
|
crystallin, gamma MX |
|
| chr3_-_61185746 Show fit | 2.01 |
ENSDART00000028219
|
parvalbumin 4 |
|
| chr16_+_23403602 Show fit | 2.01 |
ENSDART00000159848
|
S100 calcium binding protein W |
|
| chr3_-_32818607 Show fit | 1.79 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr22_+_37888249 Show fit | 1.78 |
ENSDART00000076082
|
fetuin B |
Network of associatons between targets according to the STRING database.
First level regulatory network of smarcc1a+smarcc1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.2 | 3.3 | GO:1903963 | icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 0.0 | 3.3 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.2 | 3.0 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.2 | 3.0 | GO:0048385 | regulation of retinoic acid receptor signaling pathway(GO:0048385) |
| 0.2 | 2.8 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
| 0.2 | 2.7 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.1 | 2.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.2 | 2.5 | GO:0014036 | neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036) |
| 0.1 | 2.5 | GO:1903670 | regulation of sprouting angiogenesis(GO:1903670) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 5.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 3.4 | GO:0044420 | extracellular matrix component(GO:0044420) |
| 0.1 | 3.0 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 3.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 3.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 2.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.9 | 2.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 2.7 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 2.6 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 8.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 5.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 3.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 2.8 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 2.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 2.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 2.3 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.1 | 2.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 2.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 2.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 1.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 1.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.0 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.9 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |