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PRJNA195909:zebrafish embryo and larva development

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Results for six6a+six6b

Z-value: 0.81

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Transcription factors associated with six6a+six6b

Gene Symbol Gene ID Gene Info
ENSDARG00000025187 SIX homeobox 6a
ENSDARG00000031316 SIX homeobox 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six6adr11_v1_chr13_+_31603988_316039880.853.9e-03Click!
six6bdr11_v1_chr20_-_20533865_205338650.845.0e-03Click!

Activity profile of six6a+six6b motif

Sorted Z-values of six6a+six6b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_51098036 3.07 ENSDART00000184118

chr25_+_31277415 2.00 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr9_-_22310919 1.93 ENSDART00000108719
crystallin, gamma M2d10
chr13_+_35745572 1.88 ENSDART00000159690
G protein-coupled receptor 75
chr22_-_10459880 1.56 ENSDART00000064801
osteoglycin
chr23_-_42232124 1.37 ENSDART00000149944
glutathione peroxidase 7
chr2_-_44946094 1.26 ENSDART00000036997
calcium/calmodulin-dependent protein kinase II inhibitor 1a
chr14_+_50770537 1.19 ENSDART00000158723
synuclein, beta
chr10_-_24648228 1.12 ENSDART00000081834
ENSDART00000132830
stomatin (EPB72)-like 3b
chr17_+_51627209 1.06 ENSDART00000056886
zgc:113142
chr15_-_1822548 0.96 ENSDART00000082026
ENSDART00000180230
matrix metallopeptidase 28
chr20_+_37383034 0.96 ENSDART00000134997
ENSDART00000145927
adhesion G protein-coupled receptor G6
chr1_+_1789357 0.94 ENSDART00000006449
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2
chr18_-_14677936 0.88 ENSDART00000111995
si:dkey-238o13.4
chr2_+_47581997 0.87 ENSDART00000112579
secretogranin II (chromogranin C), b
chr22_+_13977772 0.84 ENSDART00000080313
ADP-ribosylation factor-like 4Ca
chr16_+_46492756 0.83 ENSDART00000105931
rapunzel 5
chr13_+_28819768 0.82 ENSDART00000191401
ENSDART00000188895
ENSDART00000101653

chr12_+_2446837 0.80 ENSDART00000112032
si:dkey-191m6.4
chr13_-_16257848 0.73 ENSDART00000079745
zgc:110045
chr3_+_23726148 0.70 ENSDART00000174580
homeobox B3a
chr19_-_32710922 0.67 ENSDART00000004034
hippocalcin
chr7_+_20535869 0.67 ENSDART00000078181
zgc:158423
chr13_+_49175624 0.65 ENSDART00000193550
egl-9 family hypoxia-inducible factor 1a
chr3_+_23731109 0.65 ENSDART00000131410
homeobox B3a
chr19_-_17774875 0.62 ENSDART00000151133
ENSDART00000130695
DNA topoisomerase II beta
chr21_-_42007213 0.61 ENSDART00000188804
ENSDART00000092821
ENSDART00000165743
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr3_+_25154078 0.61 ENSDART00000156973
si:ch211-256m1.8
chr20_-_9580446 0.59 ENSDART00000014168
zinc finger protein 36, C3H type-like 1b
chr11_-_31039533 0.59 ENSDART00000127355
immediate early response 2b
chr7_+_22767678 0.58 ENSDART00000137203
plac8 onzin related protein 6
chr21_+_51521 0.58 ENSDART00000007672
dimethylglycine dehydrogenase
chr9_+_907459 0.56 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr15_-_42736433 0.55 ENSDART00000154379
si:ch211-181d7.1
chr16_+_6632969 0.55 ENSDART00000109276
spalt-like transcription factor 3a
chr16_+_46492994 0.54 ENSDART00000134734
rapunzel 5
chr13_+_42544009 0.54 ENSDART00000145409
si:dkey-221j11.3
chr21_-_25756119 0.53 ENSDART00000002341
claudin c
chr11_+_40812590 0.53 ENSDART00000186690
ERBB receptor feedback inhibitor 1a
chr2_-_30249746 0.52 ENSDART00000124153
ENSDART00000142575
elongin C paralog b
chr4_+_76637548 0.52 ENSDART00000133799
membrane-spanning 4-domains, subfamily A, member 17A.9
chr10_-_25816558 0.51 ENSDART00000017240
periostin, osteoblast specific factor a
chr6_+_28124393 0.51 ENSDART00000089195
G protein-coupled receptor 17
chr23_-_44226556 0.48 ENSDART00000149115
zgc:158659
chr7_-_31932723 0.45 ENSDART00000014843
brain-derived neurotrophic factor
chr20_+_51104367 0.44 ENSDART00000073981
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr16_+_9609721 0.43 ENSDART00000047920
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr22_-_3261879 0.43 ENSDART00000159643
G protein-coupled receptor 35, tandem duplicate 1
chr3_+_50069204 0.43 ENSDART00000184243
zgc:103625
chr10_-_43540196 0.42 ENSDART00000170891
si:ch73-215f7.1
chr16_+_41570653 0.42 ENSDART00000102665
asteroid homolog 1a
chr2_-_27775236 0.40 ENSDART00000187983
zgc:123035
chr8_-_50259448 0.40 ENSDART00000146056
NK3 homeobox 1
chr21_-_3796461 0.40 ENSDART00000021976
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr15_-_31514818 0.40 ENSDART00000153978
high mobility group box 1b
chr15_-_20939579 0.40 ENSDART00000152371
ubiquitin specific peptidase 2a
chr8_+_52701811 0.39 ENSDART00000179692
BCL2 like 16
chr25_+_3306620 0.37 ENSDART00000182085
ENSDART00000034704
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b
chr18_+_12058403 0.37 ENSDART00000140854
ENSDART00000193632
ENSDART00000190519
ENSDART00000190685
ENSDART00000112671
bicaudal D homolog 1a
chr23_+_32335871 0.37 ENSDART00000149698
solute carrier family 39 (zinc transporter), member 5
chr5_+_64368770 0.37 ENSDART00000162246
phospholipid phosphatase 7 (inactive)
chr19_-_3925801 0.36 ENSDART00000129570
ENSDART00000163138
si:ch73-281i18.6
chr21_-_42055872 0.36 ENSDART00000144767
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr22_+_19640309 0.36 ENSDART00000061725
ENSDART00000140819
RGM domain family, member D
chr20_-_49729446 0.35 ENSDART00000111089
filamin A interacting protein 1b
chr19_-_3906369 0.35 ENSDART00000160299
ENSDART00000169205
si:ch73-281i18.4
chr14_+_45883687 0.33 ENSDART00000114790
fibronectin leucine rich transmembrane protein 1b
chr3_+_37707432 0.33 ENSDART00000151236
mitogen-activated protein kinase kinase kinase 14a
chr2_-_30250311 0.32 ENSDART00000184144
elongin C paralog b
chr10_+_41549819 0.31 ENSDART00000114210

chr24_-_20016817 0.31 ENSDART00000082201
ENSDART00000189448
solute carrier family 22 member 13b
chr8_+_28259347 0.31 ENSDART00000110857
family with sequence similarity 212, member B
chr1_+_34527213 0.31 ENSDART00000180483
Kruppel-like factor 12a
chr20_+_5132138 0.30 ENSDART00000081351
ENSDART00000157685
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1
chr14_-_17306261 0.30 ENSDART00000191747
janus kinase and microtubule interacting protein 1
chr21_-_26250744 0.29 ENSDART00000044735
glutamate receptor, ionotropic, AMPA 1b
chr4_-_25858620 0.28 ENSDART00000128968
nuclear receptor subfamily 2, group C, member 1
chr18_+_14693682 0.28 ENSDART00000132249
URI1, prefoldin-like chaperone
chr2_+_51796441 0.28 ENSDART00000165151
crystallin, gamma N1
chr6_-_28980756 0.27 ENSDART00000014661
glomulin, FKBP associated protein b
chr21_-_2707768 0.26 ENSDART00000165384

chr21_+_11105007 0.26 ENSDART00000128859
ENSDART00000193105
prolactin receptor a
chr24_+_15670013 0.26 ENSDART00000185826

chr20_+_1960092 0.26 ENSDART00000191892

chr21_-_26250443 0.25 ENSDART00000123713
glutamate receptor, ionotropic, AMPA 1b
chr9_+_38292947 0.25 ENSDART00000146663
transcription factor CP2-like 1
chr22_+_9751117 0.24 ENSDART00000121827

chr4_-_25859305 0.24 ENSDART00000159528
nuclear receptor subfamily 2, group C, member 1
chr1_+_14466860 0.23 ENSDART00000114097
tromal interaction molecule 2a
chr9_-_5263947 0.23 ENSDART00000088342
cytohesin 1 interacting protein
chr4_+_76752707 0.23 ENSDART00000082121
membrane-spanning 4-domains, subfamily A, member 17A.4
chr1_-_12161148 0.23 ENSDART00000166429
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr7_-_36358735 0.22 ENSDART00000188392
fat mass and obesity associated
chr10_-_5821584 0.22 ENSDART00000166388
interleukin 6 signal transducer
chr15_-_25527580 0.22 ENSDART00000167005
ENSDART00000157498
hypoxia-inducible factor 1, alpha subunit, like
chr14_-_21959712 0.21 ENSDART00000021417
purinergic receptor P2X, ligand-gated ion channel, 3a
chr11_-_27702778 0.21 ENSDART00000045942
ENSDART00000125352
PHD finger protein 2
chr16_+_49005321 0.20 ENSDART00000160919

chr2_-_732864 0.19 ENSDART00000168585

chr19_+_27342479 0.19 ENSDART00000184687
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr13_-_18195942 0.19 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr6_-_49159207 0.18 ENSDART00000041942
tetraspanin 2a
chr16_-_44709832 0.18 ENSDART00000156784
si:ch211-151m7.6
chr23_-_36934944 0.18 ENSDART00000109976
ENSDART00000162179
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr13_+_45772924 0.17 ENSDART00000146964
si:ch211-62a1.3
chr4_-_73266929 0.17 ENSDART00000158194
wu:fc30c06
chr18_+_31410652 0.17 ENSDART00000098504
differentially expressed in FDCP 8 homolog (mouse)
chr24_+_2962988 0.17 ENSDART00000164449
enoyl-CoA delta isomerase 2
chr25_+_22643954 0.17 ENSDART00000182843
ENSDART00000121791
Usher syndrome 1C
chr2_-_144393 0.16 ENSDART00000156008
adenylate cyclase 1b
chr9_-_19583704 0.16 ENSDART00000053218
transmembrane protease, serine 3a
chr18_-_48755037 0.16 ENSDART00000109673
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
chr1_-_10347198 0.15 ENSDART00000109141
ENSDART00000152565
si:ch211-243g6.3
chr8_+_18615938 0.14 ENSDART00000089161
si:ch211-232d19.4
chr4_-_13902188 0.14 ENSDART00000032805
glucoside xylosyltransferase 1b
chr14_-_2318590 0.14 ENSDART00000192735
protocadherin 2 alpha b 8
chr12_+_7254112 0.14 ENSDART00000092009
transcription factor A, mitochondrial
chr3_-_22214029 0.14 ENSDART00000154818
microtubule-associated protein tau b
chr12_-_21834611 0.14 ENSDART00000179553
thyroid hormone receptor alpha b
chr20_+_34596205 0.14 ENSDART00000138338
si:ch211-242b18.1
chr21_+_35289469 0.13 ENSDART00000155140
interleukin 12B, b
chr15_-_669476 0.13 ENSDART00000153687
ENSDART00000030603
si:ch211-210b2.2
chr23_+_45027263 0.12 ENSDART00000058364
high mobility group box 2b
chr9_+_41156818 0.12 ENSDART00000105764
ENSDART00000147052
signal transducer and activator of transcription 4
chr19_+_206835 0.12 ENSDART00000161137
sodium channel, voltage-gated, type I, beta b
chr2_-_9607879 0.12 ENSDART00000056899
thioredoxin domain containing 12 (endoplasmic reticulum)
chr5_+_36661058 0.12 ENSDART00000125653
calpain, small subunit 1 a
chr5_-_54160809 0.12 ENSDART00000158981
Rho guanine nucleotide exchange factor (GEF) 15
chr13_-_47810394 0.12 ENSDART00000105025
zmp:0000001138
chr17_+_23255365 0.11 ENSDART00000180277

chr24_-_25788841 0.11 ENSDART00000132235
kelch-like family member 24b
chr20_+_12702923 0.10 ENSDART00000163499
zgc:153383
chr14_-_8625845 0.10 ENSDART00000054760
zgc:162144
chr2_+_53357953 0.10 ENSDART00000187577
cugbp, Elav-like family member 5b
chr8_-_13184989 0.10 ENSDART00000135738
zgc:194990
chr18_+_19842569 0.10 ENSDART00000147470
IQ motif containing H
chr1_-_55888970 0.09 ENSDART00000064194
anti-silencing function 1Bb histone chaperone
chr21_-_280769 0.09 ENSDART00000157753
plasminogen receptor, C-terminal lysine transmembrane protein
chr7_-_44970682 0.09 ENSDART00000144591
family with sequence similarity 96, member B
chr20_-_37287107 0.08 ENSDART00000076309
neuromedin B receptor
chr6_-_32315494 0.08 ENSDART00000127879
autophagy related 4C, cysteine peptidase
chr15_+_11840311 0.08 ENSDART00000167671
protein kinase D2
chr1_-_19233890 0.08 ENSDART00000127145
protein tyrosine phosphatase, receptor type, D, b
chr15_+_15390882 0.08 ENSDART00000062024
carbonic anhydrase IV b
chr15_-_39955785 0.07 ENSDART00000154556
mutS homolog 5
chr16_-_4769877 0.07 ENSDART00000149421
ENSDART00000054078
replication protein A2
chr17_+_24722646 0.07 ENSDART00000138356
mitochondrial fission regulator 1-like
chr10_-_39198942 0.07 ENSDART00000077619
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) b
chr21_-_35428039 0.07 ENSDART00000193298
si:dkeyp-23e4.3
chr3_-_12227359 0.07 ENSDART00000167356
transcription factor AP-4 (activating enhancer binding protein 4)
chr21_+_6197223 0.06 ENSDART00000147716
si:dkey-93m18.3
chr23_+_41679586 0.06 ENSDART00000067662

chr10_+_44903676 0.06 ENSDART00000158553
zgc:114173
chr1_+_27713380 0.06 ENSDART00000169584
si:dkey-29d5.1
chr23_+_37955041 0.05 ENSDART00000087148
cerebellin 4 precursor
chr17_+_25331576 0.05 ENSDART00000157309
transmembrane protein 54a
chr5_-_30079434 0.05 ENSDART00000133981
beta-carotene oxygenase 2a
chr12_-_43428542 0.05 ENSDART00000192266
protein tyrosine phosphatase, receptor type, E, a
chr18_-_19350792 0.05 ENSDART00000147902
multiple EGF-like-domains 11
chr6_+_11026866 0.05 ENSDART00000189619
ATP-binding cassette, sub-family C (CFTR/MRP), member 6a
chr12_-_16380961 0.05 ENSDART00000086984
HECT domain containing 2
chr9_-_54304684 0.04 ENSDART00000109512
interleukin 13
chr8_-_38810233 0.04 ENSDART00000085304
proprotein convertase subtilisin/kexin type 5b
chr5_-_57526807 0.04 ENSDART00000022866
phosphatidylserine decarboxylase
chr18_-_17724295 0.03 ENSDART00000121553
family with sequence similarity 192, member A
chr1_+_9086942 0.03 ENSDART00000055023
calcium channel, voltage-dependent, gamma subunit 3a
chr17_+_28882977 0.03 ENSDART00000153937
protein kinase D1
chr11_+_37612672 0.03 ENSDART00000157993
heterochromatin protein 1, binding protein 3
chr1_+_23408622 0.03 ENSDART00000140706
cholinergic receptor, nicotinic, alpha 9
chr17_-_15611744 0.03 ENSDART00000010496
four and a half LIM domains 5
chr2_+_45521883 0.03 ENSDART00000139580
AKNA domain containing 1
chr18_+_16133595 0.03 ENSDART00000080423
cathepsin D
chr15_-_31419805 0.03 ENSDART00000060111
odorant receptor, family D, subfamily 111, member 11
chr5_+_37890521 0.03 ENSDART00000140207
transmembrane protease, serine 4b
chr2_+_3881000 0.02 ENSDART00000081897
membrane protein, palmitoylated 7b (MAGUK p55 subfamily member 7)
chr23_-_7826849 0.02 ENSDART00000157612
myelin transcription factor 1b
chr6_-_43882696 0.02 ENSDART00000064938
forkhead box P1b
chr2_+_1881334 0.02 ENSDART00000161420
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr22_-_12862415 0.02 ENSDART00000145156
ENSDART00000137280
glutaminase a
chr8_-_8698607 0.02 ENSDART00000046712
zgc:86609
chr24_+_13017586 0.02 ENSDART00000142457
staufen double-stranded RNA binding protein 2
chr15_-_762319 0.02 ENSDART00000154306
ENSDART00000157492
si:dkey-7i4.16
zinc finger protein 1011
chr3_-_39305291 0.02 ENSDART00000102674
phospholipase C, delta 3a
chr24_-_12981423 0.01 ENSDART00000133166
ENSDART00000131370
ENSDART00000002992
ddb1 and cul4 associated factor 11
chr19_+_35002479 0.01 ENSDART00000103266
WDYHV motif containing 1
chr3_-_18711288 0.01 ENSDART00000183885
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr20_-_36393555 0.01 ENSDART00000153421
si:dkey-1j5.4
chr22_+_2247645 0.01 ENSDART00000143366
ENSDART00000147852
si:dkey-4c15.8
chr8_-_37461835 0.01 ENSDART00000013446
eukaryotic translation initiation factor 2D
chr4_-_73572030 0.01 ENSDART00000121652
zinc finger protein 1015

Network of associatons between targets according to the STRING database.

First level regulatory network of six6a+six6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.2 1.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.6 GO:0007412 axon target recognition(GO:0007412)
0.1 0.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.2 GO:0042245 RNA repair(GO:0042245)
0.1 0.2 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 1.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 0.4 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.1 0.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 0.9 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.6 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0010359 regulation of anion channel activity(GO:0010359)
0.0 0.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 2.0 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.9 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769) detoxification of inorganic compound(GO:0061687)
0.0 0.9 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.0 0.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.7 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.8 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.0 0.2 GO:0033198 response to ATP(GO:0033198)
0.0 2.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 1.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.2 GO:0046549 startle response(GO:0001964) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 1.4 GO:0006979 response to oxidative stress(GO:0006979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.4 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.8 GO:0070449 elongin complex(GO:0070449)
0.0 2.0 GO:0005861 troponin complex(GO:0005861)
0.0 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 1.2 GO:0043679 axon terminus(GO:0043679)
0.0 1.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1903136 cuprous ion binding(GO:1903136)
0.2 1.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 0.6 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.6 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.1 0.6 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.3 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 0.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 1.0 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 1.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.2 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.1 0.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.3 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 1.9 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 1.0 GO:0043236 laminin binding(GO:0043236)
0.0 0.5 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 0.7 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism