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PRJNA195909:zebrafish embryo and larva development

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Results for six3a+six3b+six7_six1a+six2a+six2b+six5+six9_six1b

Z-value: 1.50

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Transcription factors associated with six3a+six3b+six7_six1a+six2a+six2b+six5+six9_six1b

Gene Symbol Gene ID Gene Info
six3b
ENSDARG00000054879 SIX homeobox 3b
six3a
ENSDARG00000058008 SIX homeobox 3a
six7
ENSDARG00000070107 SIX homeobox 7
six3a
ENSDARG00000114971 SIX homeobox 3a
six1a
ENSDARG00000039304 SIX homeobox 1a
six2b
ENSDARG00000054878 SIX homeobox 2b
six2a
ENSDARG00000058004 SIX homeobox 2a
six5
ENSDARG00000068406 SIX homeobox 5
six9
ENSDARG00000068407 SIX homeobox 9
six2a
ENSDARG00000115214 SIX homeobox 2a
six1b
ENSDARG00000026473 SIX homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six5dr11_v1_chr18_-_37252036_372520360.933.4e-04Click!
six3bdr11_v1_chr12_+_25600685_25600685-0.915.8e-04Click!
six1bdr11_v1_chr20_+_20499869_20499869-0.916.2e-04Click!
six2bdr11_v1_chr12_-_25612170_25612170-0.917.3e-04Click!
six1adr11_v1_chr13_-_31622195_31622195-0.881.8e-03Click!
six2adr11_v1_chr13_+_10232695_10232695-0.863.1e-03Click!
six3adr11_v1_chr13_-_10261383_10261383-0.827.0e-03Click!
six9dr11_v1_chr18_-_37241080_37241115-0.551.3e-01Click!
six7dr11_v1_chr7_-_7420301_7420301-0.353.6e-01Click!

Activity profile of six3a+six3b+six7_six1a+six2a+six2b+six5+six9_six1b motif

Sorted Z-values of six3a+six3b+six7_six1a+six2a+six2b+six5+six9_six1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_42898220 5.45 ENSDART00000099270
CU326366.2

chr19_-_20403845 4.30 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
dazl
deleted in azoospermia-like
chr1_-_24255149 3.01 ENSDART00000146960
lrba
LPS-responsive vesicle trafficking, beach and anchor containing
chr21_-_7940043 2.99 ENSDART00000099733
ENSDART00000136671
f2rl1.1
coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1
chr10_+_10972795 2.86 ENSDART00000127331
cdc37l1
cell division cycle 37-like 1
chr15_-_30505607 2.60 ENSDART00000155212
msi2b
musashi RNA-binding protein 2b
chr25_-_21763750 2.50 ENSDART00000089596
tmem168b
transmembrane protein 168b
chr16_+_50755133 2.48 ENSDART00000029283
IGLON5
zgc:110372
chr15_+_17446796 2.22 ENSDART00000157189
snx19b
sorting nexin 19b
chr20_+_37866861 2.15 ENSDART00000153220
vash2
vasohibin 2
chr10_+_42898103 2.09 ENSDART00000015872
zcchc9
zinc finger, CCHC domain containing 9
chr19_+_34230108 2.07 ENSDART00000141950
galnt12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12
chr17_+_16429826 1.78 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr23_+_39481537 1.72 ENSDART00000187222
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr16_-_46567344 1.72 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr16_+_26735894 1.70 ENSDART00000191605
ENSDART00000185175
rad54b
RAD54 homolog B (S. cerevisiae)
chr16_+_41060161 1.67 ENSDART00000141130
scap
SREBF chaperone
chr20_+_4221978 1.60 ENSDART00000171898
ipcef1
interaction protein for cytohesin exchange factors 1
chr14_+_22397251 1.56 ENSDART00000185239
ENSDART00000124072
ENSDART00000054977
atp7a
ATPase copper transporting alpha
chr12_+_13742953 1.54 ENSDART00000152257
ppp1r16a
protein phosphatase 1, regulatory subunit 16A
chr21_-_21465111 1.45 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr17_-_2573021 1.40 ENSDART00000074181
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr12_+_13742778 1.32 ENSDART00000111401
ENSDART00000190552
ppp1r16a
protein phosphatase 1, regulatory subunit 16A
chr20_+_22067337 1.22 ENSDART00000152636
clocka
clock circadian regulator a
chr21_-_26028205 1.16 ENSDART00000034875
sdf2
stromal cell-derived factor 2
chr9_-_13871935 1.08 ENSDART00000146597
raph1a
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr8_-_25566347 1.06 ENSDART00000138289
ENSDART00000078022
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr7_-_71486162 1.06 ENSDART00000045253
aco1
aconitase 1, soluble
chr17_-_6600899 1.06 ENSDART00000154074
ENSDART00000180912
ANKRD66
si:ch211-189e2.2
chr8_+_20440297 1.05 ENSDART00000189486
mknk2b
MAP kinase interacting serine/threonine kinase 2b
chr4_-_7811925 1.04 ENSDART00000103070
cdk17
cyclin-dependent kinase 17
chr20_+_34502606 1.02 ENSDART00000139739
gorab
golgin, rab6-interacting
chr11_-_24016761 1.00 ENSDART00000153601
ENSDART00000067817
ENSDART00000170531
chia.3
chitinase, acidic.3
chr18_-_49283058 0.98 ENSDART00000076554
si:zfos-464b6.2
si:zfos-464b6.2
chr5_+_37903790 0.92 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr5_-_26247973 0.90 ENSDART00000098527
erap1b
endoplasmic reticulum aminopeptidase 1b
chr21_+_18405585 0.87 ENSDART00000139318
si:dkey-1d7.3
si:dkey-1d7.3
chr5_+_41477526 0.87 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr21_+_45519373 0.85 ENSDART00000183665
fnip1
folliculin interacting protein 1
chr5_+_41477954 0.84 ENSDART00000185871
pias2
protein inhibitor of activated STAT, 2
chr7_-_29356084 0.73 ENSDART00000075757
gtf2a2
general transcription factor IIA, 2
chr23_-_27045231 0.70 ENSDART00000187979
zgc:66440
zgc:66440
chr13_+_33368140 0.68 ENSDART00000033848
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr13_-_3324764 0.65 ENSDART00000102748
ENSDART00000114040
ubr2
ubiquitin protein ligase E3 component n-recognin 2
chr17_+_13099476 0.65 ENSDART00000012670
pnn
pinin, desmosome associated protein
chr1_+_532766 0.63 ENSDART00000179731
ENSDART00000060944
mrpl39
mitochondrial ribosomal protein L39
chr13_+_25549425 0.61 ENSDART00000087553
ENSDART00000169199
sec23ip
SEC23 interacting protein
chr2_-_32366287 0.59 ENSDART00000144758
ubtfl
upstream binding transcription factor, like
chr5_-_54395488 0.57 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr7_-_59515569 0.57 ENSDART00000163343
ENSDART00000165457
ENSDART00000163745
slx1b
SLX1 homolog B, structure-specific endonuclease subunit
chr6_-_7686594 0.56 ENSDART00000091836
ENSDART00000151697
ubn2a
ubinuclein 2a
chr21_-_13972745 0.55 ENSDART00000143874
akna
AT-hook transcription factor
chr12_+_9183626 0.55 ENSDART00000020192
tubgcp2
tubulin, gamma complex associated protein 2
chr24_+_30435164 0.54 ENSDART00000193877
dpyda.1
dihydropyrimidine dehydrogenase a, tandem duplicate 1
chr2_-_27473645 0.53 ENSDART00000186152
CU469530.2

chr20_+_4222357 0.53 ENSDART00000188331
ipcef1
interaction protein for cytohesin exchange factors 1
chr13_-_18122333 0.53 ENSDART00000128748
washc2c
WASH complex subunit 2C
chr9_-_28990649 0.52 ENSDART00000078823
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a
chr22_-_5171362 0.51 ENSDART00000124889
tnfaip8l1
tumor necrosis factor, alpha-induced protein 8-like 1
chr8_-_26961779 0.50 ENSDART00000099214
slc16a1b
solute carrier family 16 (monocarboxylate transporter), member 1b
chr8_+_7801060 0.49 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr3_-_5067585 0.48 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr20_-_45058041 0.48 ENSDART00000124298
klhl29
kelch-like family member 29
chr5_+_13326765 0.43 ENSDART00000090851
ydjc
YdjC chitooligosaccharide deacetylase homolog
chr25_-_37180969 0.41 ENSDART00000152338
tdrd12
tudor domain containing 12
chr20_+_13783040 0.41 ENSDART00000115329
ENSDART00000152497
lpgat1
lysophosphatidylglycerol acyltransferase 1
chr11_+_1602916 0.39 ENSDART00000184434
ENSDART00000112597
ENSDART00000192165
si:dkey-40c23.2
si:dkey-40c23.3
si:dkey-40c23.2
si:dkey-40c23.3
chr6_-_40899618 0.38 ENSDART00000153949
ENSDART00000021969
zgc:172271
zgc:172271
chr10_-_32610776 0.36 ENSDART00000017436
mogat2
monoacylglycerol O-acyltransferase 2
chr15_-_43270889 0.35 ENSDART00000166805
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr14_-_470505 0.35 ENSDART00000067147
ANKRD50
ankyrin repeat domain 50
chr15_-_38218320 0.35 ENSDART00000152363
rhoga
ras homolog family member Ga
chr1_+_37752171 0.34 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
GALNTL6
si:ch211-15e22.3
chr24_-_18809433 0.33 ENSDART00000152009
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr15_+_40792667 0.33 ENSDART00000193186
ENSDART00000184559
fat3a
FAT atypical cadherin 3a
chr10_+_14488625 0.32 ENSDART00000026383
sigmar1
sigma non-opioid intracellular receptor 1
chr7_+_56517402 0.30 ENSDART00000073597
dhodh
dihydroorotate dehydrogenase
chr2_+_6999369 0.30 ENSDART00000050597
xpr1b
xenotropic and polytropic retrovirus receptor 1b
chr7_-_38183331 0.29 ENSDART00000149382
abcc12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr2_-_38312757 0.29 ENSDART00000167274
ap1g2
adaptor-related protein complex 1, gamma 2 subunit
chr4_+_20085114 0.27 ENSDART00000186698
ENSDART00000188635
ppp6r2a
protein phosphatase 6, regulatory subunit 2a
chr2_+_26240631 0.26 ENSDART00000129895
palm1b
paralemmin 1b
chr15_+_21882419 0.26 ENSDART00000157216
si:dkey-103g5.4
si:dkey-103g5.4
chr13_-_40120252 0.25 ENSDART00000157852
crtac1b
cartilage acidic protein 1b
chr6_-_28222592 0.25 ENSDART00000131126
bcl6a
B-cell CLL/lymphoma 6a (zinc finger protein 51)
chr5_+_26806141 0.24 ENSDART00000142753
rabl6b
RAB, member RAS oncogene family-like 6b
chr15_-_15910226 0.23 ENSDART00000154219
synrg
synergin, gamma
chr19_-_22664128 0.23 ENSDART00000136295
eif3eb
eukaryotic translation initiation factor 3, subunit E, b
chr11_+_24002503 0.23 ENSDART00000164702
chia.2
chitinase, acidic.2
chr10_+_40624702 0.22 ENSDART00000109129
zgc:172131
zgc:172131
chr11_-_44194132 0.22 ENSDART00000182954
ENSDART00000111271
CABZ01080074.1

chr17_+_31739418 0.22 ENSDART00000155073
ENSDART00000156180
arhgap5
Rho GTPase activating protein 5
chr4_-_49720388 0.22 ENSDART00000154146
znf1057
zinc finger protein 1057
chr17_+_10593398 0.19 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr7_-_40657831 0.19 ENSDART00000084153
nom1
nucleolar protein with MIF4G domain 1
chr20_-_44460789 0.19 ENSDART00000085442
mut
methylmalonyl CoA mutase
chr14_+_1355857 0.18 ENSDART00000188008
bbs12
Bardet-Biedl syndrome 12
chr22_-_24967348 0.18 ENSDART00000153490
ENSDART00000084871
fam20cl
family with sequence similarity 20, member C like
chr22_-_11520405 0.17 ENSDART00000063157
slc26a11
solute carrier family 26 (anion exchanger), member 11
chr25_-_20238793 0.16 ENSDART00000145987
dnm1l
dynamin 1-like
chr3_-_21094437 0.16 ENSDART00000153739
ENSDART00000109790
nlk1
nemo-like kinase, type 1
chr25_-_19068557 0.14 ENSDART00000184780
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr17_+_132555 0.14 ENSDART00000158159
zgc:77287
zgc:77287
chr9_+_46644633 0.14 ENSDART00000160285
slc4a3
solute carrier family 4 (anion exchanger), member 3
chr9_+_26086135 0.14 ENSDART00000011910
arglu1a
arginine and glutamate rich 1a
chr22_+_2315996 0.13 ENSDART00000132489
znf1175
zinc finger protein 1175
chr10_+_35468978 0.13 ENSDART00000131984
phldb2a
pleckstrin homology-like domain, family B, member 2a
chr4_-_13502549 0.12 ENSDART00000140366
si:ch211-266a5.12
si:ch211-266a5.12
chr21_-_2158298 0.11 ENSDART00000182199
gb:ai877918
expressed sequence AI877918
chr6_+_52947699 0.11 ENSDART00000180913
uba7
ubiquitin-like modifier activating enzyme 7
chr19_-_11949996 0.11 ENSDART00000163478
ENSDART00000167299
cpsf1
cleavage and polyadenylation specific factor 1
chr7_-_47381146 0.11 ENSDART00000185596
AL935126.2

chr25_+_18953756 0.11 ENSDART00000154291
tdg.2
thymine DNA glycosylase, tandem duplicate 2
chr7_-_36113098 0.11 ENSDART00000064913
fto
fat mass and obesity associated
chr9_+_53637932 0.11 ENSDART00000188962
CABZ01084081.1

chr15_-_945804 0.10 ENSDART00000063257
alox5b.1
arachidonate 5-lipoxygenase b, tandem duplicate 1
chr6_+_41186320 0.09 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr6_+_52947186 0.09 ENSDART00000155831
uba7
ubiquitin-like modifier activating enzyme 7
chr13_+_9678427 0.08 ENSDART00000153907
sema4ga
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ga
chr5_-_12823876 0.06 ENSDART00000019461
p2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
chr4_+_19127973 0.06 ENSDART00000136611
si:dkey-21o22.2
si:dkey-21o22.2
chr19_-_15434813 0.06 ENSDART00000019843
ftr55
finTRIM family, member 55
chr7_-_72423666 0.05 ENSDART00000191214
rph3ab
rabphilin 3A homolog (mouse), b
chr25_+_3788074 0.05 ENSDART00000154008
chid1
chitinase domain containing 1
chr13_+_9678262 0.05 ENSDART00000111365
sema4ga
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ga
chr2_-_51275873 0.04 ENSDART00000168019
si:ch211-215e19.4
si:ch211-215e19.4
chr10_+_40568735 0.04 ENSDART00000136468
ENSDART00000182841
taar18i
trace amine associated receptor 18i
chr16_-_46567136 0.03 ENSDART00000159180
si:dkey-152b24.7
si:dkey-152b24.7
chr23_+_3721042 0.03 ENSDART00000143323
smim29
small integral membrane protein 29
chr11_+_24339377 0.03 ENSDART00000133679
ENSDART00000135435
ENSDART00000017973
ENSDART00000131365
ENSDART00000186418
rbm39a
RNA binding motif protein 39a
chr9_+_35017702 0.01 ENSDART00000193640
gabpa
GA binding protein transcription factor, alpha subunit
chr11_-_42750626 0.00 ENSDART00000130640
si:ch73-106k19.5
si:ch73-106k19.5
chr8_+_23745167 0.00 ENSDART00000149352
si:ch211-163l21.11
si:ch211-163l21.11

Network of associatons between targets according to the STRING database.

First level regulatory network of six3a+six3b+six7_six1a+six2a+six2b+six5+six9_six1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.6 1.7 GO:0019417 sulfur oxidation(GO:0019417)
0.4 3.0 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.3 1.6 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.3 1.1 GO:0010039 response to iron ion(GO:0010039)
0.2 2.6 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.7 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.2 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.5 GO:0006212 uracil catabolic process(GO:0006212) uracil metabolic process(GO:0019860)
0.1 0.4 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 2.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 1.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 3.1 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.1 2.9 GO:0050821 protein stabilization(GO:0050821)
0.1 0.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.1 1.4 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.1 1.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.3 GO:0014004 microglia differentiation(GO:0014004)
0.0 1.5 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 1.2 GO:0009648 photoperiodism(GO:0009648)
0.0 1.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:0042245 RNA repair(GO:0042245)
0.0 0.2 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 1.7 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 2.1 GO:0045765 regulation of angiogenesis(GO:0045765)
0.0 0.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.2 0.5 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.2 0.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.6 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.1 0.7 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 2.6 GO:0005844 polysome(GO:0005844)
0.0 1.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 1.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.5 GO:0043296 apical junction complex(GO:0043296)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.5 4.3 GO:0008494 translation activator activity(GO:0008494)
0.4 3.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 1.1 GO:0003994 aconitate hydratase activity(GO:0003994)
0.3 1.6 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 1.7 GO:0015616 DNA translocase activity(GO:0015616)
0.2 1.2 GO:0070888 E-box binding(GO:0070888)
0.2 0.9 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.6 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 1.2 GO:0004568 chitinase activity(GO:0004568)
0.1 0.5 GO:0002058 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.1 0.3 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.3 GO:0015562 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
0.1 0.7 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 1.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 2.9 GO:0051087 chaperone binding(GO:0051087)
0.1 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:1990931 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 1.7 GO:0032934 sterol binding(GO:0032934)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 3.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.4 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 1.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation