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PRJNA195909:zebrafish embryo and larva development
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Results for si:dkey-18a10.3
Z-value: 1.50
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Transcription factors associated with si:dkey-18a10.3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:dkey-18a10.3 | dr11_v1_chr10_-_33572441_33572441 | 0.68 | 4.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_31372639 Show fit | 3.94 |
ENSDART00000179908
ENSDART00000135620 ENSDART00000053367 |
high mobility group nucleosomal binding domain 3 |
|
| chr9_-_22318511 Show fit | 3.64 |
ENSDART00000129295
|
crystallin, gamma M2d2 |
|
| chr20_-_53996193 Show fit | 3.64 |
ENSDART00000004756
|
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 |
|
| chr9_-_11560427 Show fit | 3.64 |
ENSDART00000127942
ENSDART00000061442 |
crystallin, beta A2b |
|
| chr7_+_38750871 Show fit | 2.71 |
ENSDART00000114238
ENSDART00000052325 ENSDART00000137001 |
coagulation factor II (thrombin) |
|
| chr7_+_29954709 Show fit | 2.71 |
ENSDART00000173904
|
alpha-tropomyosin |
|
| chr9_-_22299412 Show fit | 2.68 |
ENSDART00000139101
|
crystallin, gamma M2d21 |
|
| chr21_+_20383837 Show fit | 2.51 |
ENSDART00000026430
|
heat shock protein, alpha-crystallin-related, b11 |
|
| chr20_-_44496245 Show fit | 2.44 |
ENSDART00000012229
|
FK506 binding protein 1b |
|
| chr7_+_29955368 Show fit | 2.42 |
ENSDART00000173686
|
alpha-tropomyosin |
Network of associatons between targets according to the STRING database.
First level regulatory network of si:dkey-18a10.3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 4.5 | GO:0061515 | myeloid cell development(GO:0061515) |
| 1.3 | 3.9 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 3.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.9 | 3.6 | GO:0045428 | regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407) |
| 0.2 | 3.6 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 0.0 | 3.6 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 3.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 2.7 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 2.6 | GO:0001570 | vasculogenesis(GO:0001570) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 3.9 | GO:0000785 | chromatin(GO:0000785) |
| 0.2 | 3.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 3.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 2.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 1.9 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.1 | 1.8 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.2 | GO:0016342 | catenin complex(GO:0016342) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 4.4 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 3.7 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.2 | 3.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 3.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 3.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 3.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 2.7 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 2.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 2.0 | GO:0016623 | aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 2.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 1.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.8 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 1.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 0.8 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.6 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |