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PRJNA195909:zebrafish embryo and larva development
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Results for si:dkey-149i17.7_zic1
Z-value: 1.25
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Transcription factors associated with si:dkey-149i17.7_zic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:dkey-149i17.7 | dr11_v1_chr2_+_24885987_24885987 | 0.63 | 6.7e-02 | Click! |
| zic1 | dr11_v1_chr24_-_4973765_4973765 | -0.10 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_22158784 Show fit | 1.34 |
ENSDART00000167850
|
crystallin, gamma M2d14 |
|
| chr7_-_24699985 Show fit | 1.32 |
ENSDART00000052802
|
calbindin 2b |
|
| chr15_+_9072821 Show fit | 1.24 |
ENSDART00000154463
|
si:dkey-202g17.3 |
|
| chr20_-_43775495 Show fit | 0.96 |
ENSDART00000100610
ENSDART00000149001 ENSDART00000148809 ENSDART00000100608 |
matrilin 3a |
|
| chr18_+_907266 Show fit | 0.95 |
ENSDART00000171729
|
pyruvate kinase M1/2a |
|
| chr18_+_49411417 Show fit | 0.92 |
ENSDART00000028944
|
zmp:0000001073 |
|
| chr24_-_3419998 Show fit | 0.82 |
ENSDART00000066839
|
solute carrier family 35, member G2b |
|
| chr17_-_6382392 Show fit | 0.82 |
ENSDART00000188051
ENSDART00000192560 ENSDART00000137389 ENSDART00000115389 |
taxilin beta b |
|
| chr19_+_43297546 Show fit | 0.81 |
ENSDART00000168002
|
lysosomal protein transmembrane 5 |
|
| chr22_+_18886209 Show fit | 0.80 |
ENSDART00000144402
|
follistatin-like 3 (secreted glycoprotein) |
Network of associatons between targets according to the STRING database.
First level regulatory network of si:dkey-149i17.7_zic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271) |
| 0.0 | 1.3 | GO:0006865 | amino acid transport(GO:0006865) |
| 0.0 | 1.3 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 1.1 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.0 | 1.0 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.0 | 0.9 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.1 | 0.8 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.2 | 0.6 | GO:0097435 | fibril organization(GO:0097435) |
| 0.1 | 0.6 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.0 | 0.6 | GO:0070328 | acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.6 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 0.4 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.4 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.4 | GO:0098894 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894) |
| 0.0 | 0.4 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.2 | 1.0 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.9 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.0 | 0.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 0.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 0.7 | GO:0005351 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.2 | 0.6 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.6 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 0.6 | GO:0016805 | dipeptidase activity(GO:0016805) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |