ISMARA results: runx2a+runx2b

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PRJNA195909:zebrafish embryo and larva development

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Results for runx2a+runx2b

Z-value: 1.36

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Transcription factors associated with runx2a+runx2b

Gene Symbol	Gene ID	Gene Info
runx2a NCBI UniProt	ENSDARG00000040261	RUNX family transcription factor 2a
runx2b NCBI UniProt	ENSDARG00000059233	RUNX family transcription factor 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
runx2a	dr11_v1_chr17_+_5351922_5351922	0.66	5.5e-02	Click!
runx2b	dr11_v1_chr20_-_44055095_44055123	-0.17	6.6e-01	Click!

Activity profile of runx2a+runx2b motif

Sorted Z-values of runx2a+runx2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_14054083 Show fit	2.22	ENSDART00000009549	rhag NCBI UniProt Show fit	Rh associated glycoprotein
chr24_+_11334733 Show fit	2.15	ENSDART00000147552 ENSDART00000143171	si:dkey-12l12.1 NCBI UniProt Show fit	si:dkey-12l12.1
chr19_+_30633453 Show fit	1.99	ENSDART00000052124	fam49al NCBI UniProt Show fit	family with sequence similarity 49, member A-like
chr16_+_11724230 Show fit	1.81	ENSDART00000060266	ceacam1 NCBI UniProt Show fit	carcinoembryonic antigen-related cell adhesion molecule 1
chr13_-_39159810 Show fit	1.65	ENSDART00000131508	col9a1b NCBI UniProt Show fit	collagen, type IX, alpha 1b
chr23_-_6641223 Show fit	1.61	ENSDART00000023793	mipb NCBI UniProt Show fit	major intrinsic protein of lens fiber b
chr11_+_25481046 Show fit	1.60	ENSDART00000065940	opn1lw2 NCBI UniProt Show fit	opsin 1 (cone pigments), long-wave-sensitive, 2
chr22_-_10459880 Show fit	1.49	ENSDART00000064801	ogn NCBI UniProt Show fit	osteoglycin
chr13_-_39160018 Show fit	1.46	ENSDART00000168795	col9a1b NCBI UniProt Show fit	collagen, type IX, alpha 1b
chr21_+_7582036 Show fit	1.44	ENSDART00000135485 ENSDART00000027268	otpa NCBI UniProt Show fit	orthopedia homeobox a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of runx2a+runx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6	2.2	GO:0015840	urea transport(GO:0015840)
0.1	2.0	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
0.0	2.0	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.6	1.7	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.2	1.6	GO:0006833	water transport(GO:0006833)
0.2	1.5	GO:0051703	social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0	1.5	GO:0007602	phototransduction(GO:0007602)
0.4	1.4	GO:0061549	sympathetic ganglion development(GO:0061549)
0.1	1.3	GO:0045667	regulation of osteoblast differentiation(GO:0045667)

Showing 1 to 10 of 131 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	GO:0005581	collagen trimer(GO:0005581)
0.1	1.8	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.0	1.8	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	1.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	1.4	GO:0005882	intermediate filament(GO:0005882)
0.1	1.2	GO:0044295	axonal growth cone(GO:0044295)
0.0	1.2	GO:0005861	troponin complex(GO:0005861)
0.2	1.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	1.1	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.2	0.9	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.1	1.8	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.2	1.6	GO:0015250	water channel activity(GO:0015250)
0.2	1.5	GO:0034632	retinol transporter activity(GO:0034632)
0.0	1.5	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	1.5	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	1.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	1.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.2	GO:0030172	troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0	1.2	GO:0008171	O-methyltransferase activity(GO:0008171)

Showing 1 to 10 of 113 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	1.7	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.1	1.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.5	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.4	1.7	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	1.7	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	1.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.0	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	0.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	0.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome

Showing 1 to 10 of 35 entries

Results for runx2a+runx2b

Z-value: 1.36

Motif logo

Transcription factors associated with runx2a+runx2b

Activity-expression correlation:

Activity profile of runx2a+runx2b motif

Sorted Z-values of runx2a+runx2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of runx2a+runx2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: