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PRJNA195909:zebrafish embryo and larva development

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Results for runx2a+runx2b

Z-value: 1.36

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Transcription factors associated with runx2a+runx2b

Gene Symbol Gene ID Gene Info
ENSDARG00000040261 RUNX family transcription factor 2a
ENSDARG00000059233 RUNX family transcription factor 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
runx2adr11_v1_chr17_+_5351922_53519220.665.5e-02Click!
runx2bdr11_v1_chr20_-_44055095_44055123-0.176.6e-01Click!

Activity profile of runx2a+runx2b motif

Sorted Z-values of runx2a+runx2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_14054083 2.22 ENSDART00000009549
Rh associated glycoprotein
chr24_+_11334733 2.15 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
chr19_+_30633453 1.99 ENSDART00000052124
family with sequence similarity 49, member A-like
chr16_+_11724230 1.81 ENSDART00000060266
carcinoembryonic antigen-related cell adhesion molecule 1
chr13_-_39159810 1.65 ENSDART00000131508
collagen, type IX, alpha 1b
chr23_-_6641223 1.61 ENSDART00000023793
major intrinsic protein of lens fiber b
chr11_+_25481046 1.60 ENSDART00000065940
opsin 1 (cone pigments), long-wave-sensitive, 2
chr22_-_10459880 1.49 ENSDART00000064801
osteoglycin
chr13_-_39160018 1.46 ENSDART00000168795
collagen, type IX, alpha 1b
chr21_+_7582036 1.44 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr9_-_22205682 1.34 ENSDART00000101869
crystallin, gamma M2d12
chr25_+_7982979 1.27 ENSDART00000171904
upper zone of growth plate and cartilage matrix associated b
chr14_+_38786298 1.27 ENSDART00000164440
si:ch211-195b11.3
chr15_-_23376541 1.26 ENSDART00000078570
C1q and TNF related 5
chr17_+_26815021 1.23 ENSDART00000086885
acetylserotonin O-methyltransferase 2
chr25_+_20216159 1.22 ENSDART00000048642
troponin T2d, cardiac
chr23_+_8797143 1.21 ENSDART00000132992
SRY (sex determining region Y)-box 18
chr13_-_29424454 1.13 ENSDART00000026765
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr23_+_36653376 1.10 ENSDART00000053189
G protein-coupled receptor 182
chr21_-_26495700 1.09 ENSDART00000109379
CD248 molecule, endosialin b
chr21_-_7265219 1.06 ENSDART00000158852
EGF-like-domain, multiple 7
chr2_-_32768951 1.04 ENSDART00000004712
beaded filament structural protein 2, phakinin
chr18_-_12052132 1.03 ENSDART00000074361
zgc:110789
chr5_-_28606916 1.03 ENSDART00000026107
ENSDART00000137717
tenascin C
chr19_+_40856534 1.02 ENSDART00000051950
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_-_23118350 0.99 ENSDART00000020884
LY6/PLAUR domain containing 6
chr10_+_21797276 0.97 ENSDART00000169105
protocadherin 1 gamma 29
chr16_-_22194400 0.96 ENSDART00000186042
interleukin 6 receptor
chr12_-_25612170 0.95 ENSDART00000077155
SIX homeobox 2b
chr14_-_17068511 0.94 ENSDART00000163766
paired-like homeobox 2bb
chr7_-_2039060 0.93 ENSDART00000173879
si:cabz01007794.1
chr6_+_2097690 0.92 ENSDART00000193770
transglutaminase 2b
chr13_+_10232695 0.92 ENSDART00000080805
SIX homeobox 2a
chr8_+_21353878 0.91 ENSDART00000056420
aminolevulinate, delta-, synthase 2
chr7_-_51102479 0.90 ENSDART00000174023
collagen, type IV, alpha 6
chr3_+_30922947 0.90 ENSDART00000184060
claudin i
chr7_+_25858380 0.87 ENSDART00000148780
ENSDART00000079218
myotubularin related protein 1a
chr2_+_24304854 0.87 ENSDART00000078972
fat storage-inducing transmembrane protein 1
chr10_-_25769334 0.85 ENSDART00000134176
periostin, osteoblast specific factor a
chr23_+_3538463 0.84 ENSDART00000172758
si:dkey-9l20.3
chr21_-_20341836 0.84 ENSDART00000176689
retinol binding protein 4, like
chr7_+_46368520 0.84 ENSDART00000192821
zinc finger protein 536
chr6_-_24103666 0.84 ENSDART00000164915
scinderin like a
chr16_+_32995882 0.83 ENSDART00000170157
protease, serine, 35
chr16_-_16152199 0.82 ENSDART00000012718
fatty acid binding protein 11b
chr1_-_58064738 0.82 ENSDART00000073778
caspase b
chr1_-_38195012 0.81 ENSDART00000020409
heart and neural crest derivatives expressed 2
chr7_+_34231782 0.81 ENSDART00000173547
lactase-like a
chr6_+_52804267 0.79 ENSDART00000065681
matrilin 4
chr11_-_12051805 0.77 ENSDART00000110117
ENSDART00000182744
suppressor of cytokine signaling 7
chr23_-_7799184 0.77 ENSDART00000190946
ENSDART00000165427
myelin transcription factor 1b
chr14_+_6159162 0.77 ENSDART00000128638
Bernardinelli-Seip congenital lipodystrophy 2, like
chr19_+_16222618 0.76 ENSDART00000137189
ENSDART00000169246
ENSDART00000190583
ENSDART00000189521
protein tyrosine phosphatase, receptor type, U, a
chr15_-_24869826 0.75 ENSDART00000127047
tumor suppressor candidate 5a
chr10_-_15128771 0.75 ENSDART00000101261
secreted phosphoprotein 1
chr3_+_19621034 0.74 ENSDART00000025358
integrin beta 3a
chr2_-_31936966 0.73 ENSDART00000169484
ENSDART00000192492
ENSDART00000027689
amphiphysin
chr21_-_45073 0.73 ENSDART00000185997
betaine-homocysteine methyltransferase
chr2_-_50298337 0.73 ENSDART00000155125
contactin associated protein like 2b
chr22_+_21255860 0.72 ENSDART00000134893
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr9_-_42696408 0.72 ENSDART00000144744
collagen, type V, alpha 2a
chr17_-_10025234 0.71 ENSDART00000008355
cofilin 2 (muscle)
chr19_+_40856807 0.69 ENSDART00000139083
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr18_-_41375120 0.69 ENSDART00000098673
pentraxin 3, long a
chr9_-_46842179 0.68 ENSDART00000054137
insulin-like growth factor binding protein 5b
chr25_-_18249751 0.68 ENSDART00000153950
si:dkey-106n21.1
chr21_-_32487061 0.67 ENSDART00000114359
ENSDART00000131591
ENSDART00000131477
si:dkeyp-72g9.4
chr11_+_13630107 0.66 ENSDART00000172220
si:ch211-1a19.3
chr12_+_20336070 0.66 ENSDART00000066385
zgc:163057
chr5_-_28625515 0.66 ENSDART00000190782
ENSDART00000179736
ENSDART00000131729
tenascin C
chr7_-_40993456 0.66 ENSDART00000031700
engrailed homeobox 2a
chr2_-_54054225 0.65 ENSDART00000167239

chr15_+_37197494 0.64 ENSDART00000166203
amyloid beta (A4) precursor-like protein 1
chr1_+_2101541 0.64 ENSDART00000128187
ENSDART00000167050
ENSDART00000182153
ENSDART00000122626
ENSDART00000164488
muscleblind-like splicing regulator 2
chr2_+_2223837 0.64 ENSDART00000101038
ENSDART00000129354
transmembrane inner ear
chr20_+_20499869 0.64 ENSDART00000036124
SIX homeobox 1b
chr3_+_15271943 0.63 ENSDART00000141752
aspartate beta-hydroxylase domain containing 1
chr7_-_24364536 0.62 ENSDART00000064789
thioredoxin
chr21_-_20342096 0.62 ENSDART00000065659
retinol binding protein 4, like
chr7_-_38658411 0.61 ENSDART00000109463
ENSDART00000017155
nephrosin
chr19_+_19759577 0.60 ENSDART00000169480
homeobox A5a
chr15_-_12545683 0.60 ENSDART00000162807
sodium channel, voltage-gated, type II, beta
chr5_-_6377865 0.60 ENSDART00000031775
zgc:73226
chr16_-_36099492 0.60 ENSDART00000180905

chr25_-_3470910 0.59 ENSDART00000029067
ENSDART00000186737
HMG-box transcription factor 1
chr19_+_19786117 0.59 ENSDART00000167757
ENSDART00000163546
homeobox A1a
chr16_+_20904754 0.59 ENSDART00000006043
homeobox A11b
chr7_-_18656069 0.58 ENSDART00000021559
coronin, actin binding protein, 1B
chr3_-_28428198 0.58 ENSDART00000151546
RNA binding fox-1 homolog 1
chr7_-_28681724 0.58 ENSDART00000162400
adhesion G protein-coupled receptor G1
chr22_-_34937455 0.58 ENSDART00000169217
ENSDART00000188330
ENSDART00000165142
slit homolog 1b (Drosophila)
chr8_+_37489495 0.58 ENSDART00000141516
fibromodulin b
chr8_-_17067364 0.58 ENSDART00000132687
RAB3C, member RAS oncogene family
chr4_-_15420452 0.57 ENSDART00000016230
plexin A4
chr22_-_26100282 0.57 ENSDART00000166075
platelet-derived growth factor alpha polypeptide a
chr16_-_42013858 0.57 ENSDART00000045403
ets variant 2
chr24_-_4973765 0.57 ENSDART00000127597
zic family member 1 (odd-paired homolog, Drosophila)
chr16_+_31853919 0.56 ENSDART00000133886
atrophin 1
chr22_-_26005894 0.55 ENSDART00000105088
platelet-derived growth factor alpha polypeptide a
chr8_-_46926204 0.55 ENSDART00000188758
ENSDART00000143321
hes family bHLH transcription factor 2, tandem duplicate 1
chr6_-_39764995 0.54 ENSDART00000085277
phosphofructokinase, muscle b
chr6_-_43449013 0.54 ENSDART00000122423
2-epi-5-epi-valiolone synthase
chr16_-_17300030 0.54 ENSDART00000149267
Kell blood group, metallo-endopeptidase
chr13_+_27316934 0.54 ENSDART00000164533
eukaryotic translation elongation factor 1 alpha 1a
chr15_-_29573267 0.54 ENSDART00000099947
SAM domain, SH3 domain and nuclear localisation signals 1a
chr23_-_36724575 0.53 ENSDART00000159560
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr23_-_637347 0.53 ENSDART00000132175
L1 cell adhesion molecule, paralog b
chr7_+_60079302 0.53 ENSDART00000051524
ethanolamine-phosphate phospho-lyase
chr2_-_30182353 0.53 ENSDART00000019149
ribosomal protein L7
chr15_-_29586747 0.52 ENSDART00000076749
SAM domain, SH3 domain and nuclear localisation signals 1a
chr22_+_6677429 0.52 ENSDART00000147482
si:ch211-209l18.2
chr10_+_21796477 0.52 ENSDART00000176255
protocadherin 1 gamma 29
chr12_+_26467847 0.51 ENSDART00000022495
nudE neurodevelopment protein 1-like 1a
chr14_-_2163454 0.50 ENSDART00000160123
ENSDART00000169653
protocadherin 2 alpha b 9
protocadherin 2 alpha c
chr13_+_23157053 0.50 ENSDART00000162359
sorbin and SH3 domain containing 1
chr12_+_13905286 0.49 ENSDART00000147186
FK506 binding protein 10b
chr15_+_29088426 0.49 ENSDART00000187290
si:ch211-137a8.4
chr19_+_40350468 0.49 ENSDART00000087444
HEPACAM family member 2
chr16_-_29528198 0.48 ENSDART00000150028
one cut domain, family member, like
chr11_+_21053488 0.48 ENSDART00000189860
zgc:113307
chr16_-_42014272 0.48 ENSDART00000180488
ets variant 2
chr3_-_58650057 0.48 ENSDART00000057640
dehydrogenase/reductase (SDR family) member 7Ca
chr9_-_28867562 0.48 ENSDART00000189597
ENSDART00000060321
zgc:91818
chr23_+_36101185 0.48 ENSDART00000103139
homeobox C8a
chr9_+_42066030 0.48 ENSDART00000185311
ENSDART00000015267
poly(rC) binding protein 3
chr7_-_35516251 0.47 ENSDART00000045628
iroquois homeobox 6a
chr14_-_17068712 0.47 ENSDART00000170277
paired-like homeobox 2bb
chr7_+_63325819 0.47 ENSDART00000085612
ENSDART00000161436
protocadherin 7b
chr10_-_20453995 0.46 ENSDART00000168541
ENSDART00000164072
si:ch211-113d22.2
chr14_+_34514336 0.46 ENSDART00000024440
forkhead box I3b
chr14_-_24251057 0.46 ENSDART00000114169
BCL2 interacting protein 1a
chr10_+_37927100 0.46 ENSDART00000172548
basic helix-loop-helix family, member a9
chr5_-_39474235 0.46 ENSDART00000171557
anthrax toxin receptor 2a
chr2_+_22694382 0.46 ENSDART00000139196
kinesin family member 1Ab
chr13_-_20381485 0.46 ENSDART00000131351
si:ch211-270n8.1
chr23_-_29003864 0.46 ENSDART00000148257
castor zinc finger 1
chr16_-_54455573 0.46 ENSDART00000075275
pyruvate kinase L/R
chr1_-_8428736 0.45 ENSDART00000138435
ENSDART00000121823
synaptogyrin 3b
chr9_+_6578580 0.45 ENSDART00000061577
four and a half LIM domains 2a
chr25_-_25434479 0.45 ENSDART00000171589
v-Ha-ras Harvey rat sarcoma viral oncogene homolog a
chr11_-_27057572 0.44 ENSDART00000043091
IQ motif and Sec7 domain 1b
chr23_+_28582865 0.44 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr11_-_12051502 0.44 ENSDART00000183462
suppressor of cytokine signaling 7
chr3_+_14339728 0.44 ENSDART00000184127
phospholipid phosphatase related 2a
chr23_-_44207349 0.43 ENSDART00000186276
zgc:158659
chr4_-_11737939 0.43 ENSDART00000150299
podocalyxin-like
chr13_+_31603988 0.43 ENSDART00000030646
SIX homeobox 6a
chr22_+_9871238 0.43 ENSDART00000141085
ENSDART00000105939
si:dkey-253d23.4
chr13_-_15982707 0.43 ENSDART00000186911
ENSDART00000181072
IKAROS family zinc finger 1 (Ikaros)
chr22_-_33679277 0.43 ENSDART00000169948

chr5_+_65991152 0.42 ENSDART00000097756
lipocalin 15
chr19_+_22062202 0.42 ENSDART00000100181
spalt-like transcription factor 3b
chr13_+_25433774 0.42 ENSDART00000141255
si:dkey-51a16.9
chr3_+_54168007 0.42 ENSDART00000109894
olfactomedin 2a
chr13_-_10261383 0.42 ENSDART00000080808
SIX homeobox 3a
chr17_-_49977966 0.42 ENSDART00000183735
collagen, type XII, alpha 1a
chr24_-_21923930 0.42 ENSDART00000131944
transgelin 3b
chr8_-_29713595 0.41 ENSDART00000131988
ENSDART00000077637
macrophage expressed 1, tandem duplicate 1
chr4_-_73787702 0.41 ENSDART00000136328
ENSDART00000150546
si:dkey-262g12.3
chr15_+_19544052 0.40 ENSDART00000062560
zgc:77784
chr7_-_72605673 0.40 ENSDART00000123887
mitogen-activated protein kinase 8 interacting protein 1
chr7_-_4036875 0.40 ENSDART00000165021
NDRG family member 2
chr23_+_36122058 0.40 ENSDART00000184448
homeobox C3a
chr13_+_31108334 0.40 ENSDART00000142245
Rho GTPase activating protein 22
chr3_-_22212764 0.39 ENSDART00000155490
microtubule-associated protein tau b
chr6_+_48154954 0.39 ENSDART00000019706
polyhomeotic homolog 2b (Drosophila)
chr1_+_12231478 0.39 ENSDART00000111485
tropomodulin 1
chr22_+_18952781 0.39 ENSDART00000136390
hyperpolarization activated cyclic nucleotide-gated potassium channel 2b
chr22_-_26236188 0.39 ENSDART00000162640
ENSDART00000167169
ENSDART00000138595
complement component c3b, tandem duplicate 1
chr10_-_43771447 0.38 ENSDART00000052307
arrestin domain containing 3b
chr11_-_12051283 0.38 ENSDART00000170516
suppressor of cytokine signaling 7
chr1_+_15137901 0.38 ENSDART00000111475
protocadherin 7a
chr7_-_71829865 0.37 ENSDART00000168754
calcium channel, voltage-dependent, beta 2a
chr6_+_54142311 0.37 ENSDART00000154115
high mobility group AT-hook 1b
chr11_+_14287427 0.37 ENSDART00000180903
si:ch211-262i1.3
chr10_-_17103651 0.37 ENSDART00000108959
ring finger protein 208
chr16_+_11483811 0.37 ENSDART00000169012
ENSDART00000173042
glutamate receptor, ionotropic, kainate 5
chr1_+_1689775 0.37 ENSDART00000048828
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4
chr7_+_27290548 0.37 ENSDART00000100998
SRY (sex determining region Y)-box 6
chr1_-_55810730 0.37 ENSDART00000100551
zgc:136908
chr6_-_18121075 0.36 ENSDART00000171072
si:dkey-237i9.1
chr5_-_23277939 0.36 ENSDART00000003514
proteolipid protein 1b
chr1_-_30689004 0.36 ENSDART00000018827
dachshund c
chr19_+_32553874 0.36 ENSDART00000078197
hes-related family bHLH transcription factor with YRPW motif-like
chr16_+_30483043 0.36 ENSDART00000188034
platelet endothelial aggregation receptor 1
chr4_+_41602 0.35 ENSDART00000159640
putative homeodomain transcription factor 2
chr14_-_6727717 0.35 ENSDART00000166979
si:dkeyp-44a8.4
chr8_+_48484455 0.35 ENSDART00000122737
si:ch211-263k4.2
chr17_+_23770848 0.35 ENSDART00000079646
potassium channel, subfamily K, member 18
chr20_+_52554352 0.34 ENSDART00000153217
ENSDART00000145230
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr20_+_32406011 0.34 ENSDART00000018640
ENSDART00000137910
sorting nexin 3
chr11_+_40812590 0.34 ENSDART00000186690
ERBB receptor feedback inhibitor 1a
chr1_+_41854298 0.34 ENSDART00000192672
spermine oxidase
chr3_+_31621774 0.34 ENSDART00000076636
frizzled class receptor 2
chr14_+_30491890 0.34 ENSDART00000131174
fibroblast growth factor 20b
chr1_-_26702930 0.34 ENSDART00000109297
ENSDART00000152389
forkhead box E1
chr22_+_21317597 0.34 ENSDART00000132605
SHC (Src homology 2 domain containing) transforming protein 2
chr7_-_52950123 0.34 ENSDART00000009649
tubulin, gamma complex associated protein 4
chr4_+_20255160 0.33 ENSDART00000188658
leucine-rich repeats and transmembrane domains 2a
chr16_-_39900665 0.33 ENSDART00000136719
RNA binding motif, single stranded interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of runx2a+runx2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.6 2.2 GO:0015840 urea transport(GO:0015840)
0.4 1.2 GO:0030186 melatonin metabolic process(GO:0030186)
0.4 1.1 GO:0042908 xenobiotic transport(GO:0042908)
0.4 1.4 GO:0061549 sympathetic ganglion development(GO:0061549)
0.2 1.5 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.2 0.7 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 1.1 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.2 0.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 0.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 0.6 GO:0007414 axonal defasciculation(GO:0007414)
0.2 0.7 GO:0009957 epidermal cell fate specification(GO:0009957)
0.2 1.6 GO:0006833 water transport(GO:0006833)
0.2 1.0 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.2 0.8 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.2 0.9 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.7 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 0.4 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.3 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.1 0.8 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.3 GO:0046333 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.3 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.3 GO:1901881 positive regulation of protein depolymerization(GO:1901881)
0.1 0.3 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.1 2.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.6 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.2 GO:0010039 response to iron ion(GO:0010039)
0.1 1.3 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.1 0.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 0.2 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.5 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.6 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 0.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.2 GO:0030224 monocyte differentiation(GO:0030224)
0.1 0.3 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.1 0.2 GO:0019556 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.6 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 0.3 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.7 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.2 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.3 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 0.5 GO:0006007 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.7 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.3 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.4 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0031646 positive regulation of neurological system process(GO:0031646)
0.0 0.6 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.4 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.5 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 0.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.2 GO:0045658 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.0 0.1 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.0 0.3 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.2 GO:0031284 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0098917 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling(GO:0098917) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 1.2 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.8 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 1.5 GO:0007602 phototransduction(GO:0007602)
0.0 0.3 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 1.2 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 1.2 GO:0060840 artery development(GO:0060840)
0.0 0.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0055014 outflow tract morphogenesis(GO:0003151) atrial cardiac muscle cell development(GO:0055014)
0.0 0.2 GO:0090497 mesenchymal cell migration(GO:0090497)
0.0 0.4 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.4 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 2.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.1 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0060956 cardiac endothelial cell differentiation(GO:0003348) endocardial cell differentiation(GO:0060956)
0.0 1.0 GO:0006096 glycolytic process(GO:0006096)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.9 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.0 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.0 GO:0035902 response to immobilization stress(GO:0035902)
0.0 0.1 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.0 0.3 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 1.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.1 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.4 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.3 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.7 GO:0007596 blood coagulation(GO:0007596)
0.0 0.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0032689 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.5 GO:0021761 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.0 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0002857 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of mast cell activation(GO:0033005) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.6 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.3 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.2 GO:0045807 positive regulation of endocytosis(GO:0045807)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0061702 inflammasome complex(GO:0061702)
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 0.9 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 1.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.1 0.2 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 0.6 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 0.2 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 3.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.3 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 1.2 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.0 0.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0022627 cytosolic ribosome(GO:0022626) cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 0.9 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.7 GO:0070051 fibrinogen binding(GO:0070051)
0.2 1.5 GO:0034632 retinol transporter activity(GO:0034632)
0.2 1.6 GO:0015250 water channel activity(GO:0015250)
0.2 1.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2 0.6 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 0.5 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.1 2.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 1.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 1.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 1.2 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.2 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.1 0.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.2 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.1 0.7 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 0.5 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 1.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.2 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 1.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.6 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.7 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.0 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.3 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.1 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 1.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.5 PID INSULIN PATHWAY Insulin Pathway
0.0 0.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 1.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 0.3 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.1 2.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors