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PRJNA195909:zebrafish embryo and larva development

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Results for rfx3_rfx2+rfx4

Z-value: 3.72

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Transcription factors associated with rfx3_rfx2+rfx4

Gene Symbol Gene ID Gene Info
ENSDARG00000014550 regulatory factor X, 3 (influences HLA class II expression)
ENSDARG00000013575 regulatory factor X, 2 (influences HLA class II expression)
ENSDARG00000026395 regulatory factor X, 4
ENSDARG00000116861 regulatory factor X, 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx4dr11_v1_chr18_-_15373620_153736200.956.8e-05Click!
rfx3dr11_v1_chr10_-_625441_625441-0.915.4e-04Click!
rfx2dr11_v1_chr8_-_20118549_20118549-0.872.6e-03Click!

Activity profile of rfx3_rfx2+rfx4 motif

Sorted Z-values of rfx3_rfx2+rfx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_68789 22.05 ENSDART00000058569
claudin 1
chr9_-_712308 9.66 ENSDART00000144625
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3
chr24_-_205275 7.87 ENSDART00000108762
VOPP1, WBP1/VOPP1 family member
chr8_+_21195420 7.40 ENSDART00000100234
ENSDART00000091307
collagen, type II, alpha 1a
chr23_+_35708730 5.64 ENSDART00000009277
tubulin, alpha 1a
chr6_+_612330 5.45 ENSDART00000166872
ENSDART00000191758
kynureninase
chr16_-_45069882 5.38 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr21_+_26697536 5.32 ENSDART00000004109
guanine nucleotide binding protein (G protein), gamma 3
chr5_-_71705191 4.67 ENSDART00000187767
adenylate kinase 1
chr6_-_8736766 4.63 ENSDART00000143956
caveolae associated protein 2b
chr21_-_15929041 4.48 ENSDART00000080693
LIM homeobox 5
chr7_-_18554603 4.39 ENSDART00000108938
Myb/SANT-like DNA-binding domain containing 1
chr17_+_53186347 4.22 ENSDART00000155981
diphthamine biosynthesis 6
chr19_-_10551394 4.12 ENSDART00000186815
ENSDART00000181041
lens intrinsic membrane protein 2.4
chr13_-_31470439 4.05 ENSDART00000076574
reticulon 1a
chr7_-_34265481 3.82 ENSDART00000173596
si:ch211-98n17.5
chr3_-_1190132 3.75 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr11_-_279328 3.69 ENSDART00000066179
neuropeptide FF-amide peptide precursor like
chr7_+_1045637 3.54 ENSDART00000111531
ependymin-like 1
chr13_-_36703164 3.51 ENSDART00000044357
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr14_-_25577094 3.48 ENSDART00000163669
complexin 2
chr24_-_37680917 3.47 ENSDART00000131342
ankyrin repeat and sterile alpha motif domain containing 3
chr17_-_21784152 3.47 ENSDART00000127254
H6 family homeobox 2
chr3_+_60716904 3.44 ENSDART00000168280
forkhead box J1a
chr5_+_39563301 3.28 ENSDART00000131245
ENSDART00000097872
si:ch211-57h10.1
chr8_-_19216657 3.20 ENSDART00000135096
ENSDART00000135869
ENSDART00000145951
si:ch73-222f22.2
si:ch73-222f22.2
chr13_+_33117528 3.12 ENSDART00000085719
si:ch211-10a23.2
chr18_+_30028135 3.07 ENSDART00000140825
ENSDART00000145306
ENSDART00000136810
si:ch211-220f16.1
chr15_+_47903864 2.99 ENSDART00000063835
orthodenticle homolog 5
chr17_-_10838434 2.98 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr3_-_19899914 2.93 ENSDART00000134969
Rho family GTPase 2
chr2_+_35728033 2.93 ENSDART00000002094
ankyrin repeat domain 45
chr11_+_43661735 2.88 ENSDART00000017912
GLI family zinc finger 2b
chr25_+_37480285 2.87 ENSDART00000166187

chr10_-_29900546 2.87 ENSDART00000147441
lens intrinsic membrane protein 2.1
chr19_-_9472893 2.85 ENSDART00000045565
ENSDART00000137505
vesicle-associated membrane protein 1
chr25_+_25453571 2.84 ENSDART00000112330
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr17_+_33767890 2.81 ENSDART00000193177
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr8_-_19216180 2.73 ENSDART00000146162
si:ch73-222f22.2
chr18_+_30028637 2.72 ENSDART00000139750
si:ch211-220f16.1
chr16_+_50006872 2.68 ENSDART00000157100
ubiquitin-conjugating enzyme E2E 2
chr24_-_38816725 2.63 ENSDART00000063231
noggin 2
chr16_+_24632096 2.58 ENSDART00000157237
si:dkey-56f14.7
chr2_-_5728843 2.57 ENSDART00000014020
somatostatin 2
chr13_+_50368668 2.57 ENSDART00000127610
DnaJ (Hsp40) homolog, subfamily C, member 12
chr1_-_470812 2.56 ENSDART00000192527
zgc:92518
chr20_-_13640598 2.55 ENSDART00000128823
ENSDART00000103394
radial spoke 3 homolog
chr7_-_24236364 2.54 ENSDART00000010124
solute carrier family 7 (amino acid transporter light chain, L system), member 8a
chr5_-_23179319 2.53 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
chr17_-_6759006 2.50 ENSDART00000184692
ENSDART00000180530
visinin-like 1b
chr8_-_54304381 2.48 ENSDART00000184177
rhodopsin
chr17_-_24684687 2.48 ENSDART00000105457
MORN repeat containing 2
chr4_+_31259 2.46 ENSDART00000166826
putative homeodomain transcription factor 2
chr4_-_5652030 2.46 ENSDART00000010903
radial spoke head 9 homolog
chr21_-_5879897 2.46 ENSDART00000184034
ribosomal protein L35
chr19_+_22062202 2.43 ENSDART00000100181
spalt-like transcription factor 3b
chr24_-_24163201 2.37 ENSDART00000140170
MAP7 domain containing 2b
chr20_+_20638034 2.37 ENSDART00000189759
reticulon 1b
chr13_-_3155243 2.36 ENSDART00000139183
ENSDART00000050934
protein kinase domain containing, cytoplasmic a
chr6_+_52212927 2.36 ENSDART00000143458
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr11_-_44194132 2.35 ENSDART00000182954
ENSDART00000111271

chr20_+_20637866 2.34 ENSDART00000060203
ENSDART00000079079
reticulon 1b
chr5_-_55625247 2.30 ENSDART00000133156
heterogeneous nuclear ribonucleoprotein K, like
chr13_+_28821841 2.30 ENSDART00000179900

chr8_-_49345388 2.30 ENSDART00000053203
proteolipid protein 2
chr13_-_13294847 2.28 ENSDART00000125883
ENSDART00000013534
fibroblast growth factor receptor 3
chr6_+_52212574 2.28 ENSDART00000025940
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr1_+_54908895 2.28 ENSDART00000145652
golgin A7 family, member Ba
chr20_-_9436521 2.27 ENSDART00000133000
zgc:101840
chr8_+_23809843 2.26 ENSDART00000099724
si:ch211-163l21.10
chr6_-_21582444 2.21 ENSDART00000151339
si:dkey-43k4.3
chr16_-_24612871 2.21 ENSDART00000155614
ENSDART00000154787
ENSDART00000155983
ENSDART00000156519
FXYD domain containing ion transport regulator 6 like
chr10_-_17232372 2.20 ENSDART00000135679
RAB36, member RAS oncogene family
chr3_-_50277959 2.17 ENSDART00000082773
ENSDART00000139524
ADP-ribosylation factor-like 16
chr23_-_20133994 2.15 ENSDART00000004871
leucine rich repeat containing 23
chr10_-_36682509 2.14 ENSDART00000148093
ENSDART00000063365
DnaJ (Hsp40) homolog, subfamily B, member 13
chr24_-_24162930 2.12 ENSDART00000080602
MAP7 domain containing 2b
chr22_-_25033105 2.12 ENSDART00000124220
neuronal pentraxin receptor b
chr7_-_58098814 2.12 ENSDART00000147287
ENSDART00000043984
ankyrin 2b, neuronal
chr12_+_25600685 2.10 ENSDART00000077157
SIX homeobox 3b
chr25_+_25453221 2.08 ENSDART00000176822
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr10_-_43117607 2.06 ENSDART00000148293
ENSDART00000089965
transmembrane protein 167A
chr16_+_46492756 2.03 ENSDART00000105931
rapunzel 5
chr21_+_22423286 2.02 ENSDART00000133190
calcyphosine-like b
chr21_+_17956856 2.01 ENSDART00000080431
dynein, axonemal, intermediate chain 1, paralog 2
chr3_-_22829710 2.00 ENSDART00000055659
cytochrome b561
chr20_-_3915770 1.99 ENSDART00000159322
si:ch73-111k22.3
chr2_-_56348727 1.98 ENSDART00000060745
ubiquitin A-52 residue ribosomal protein fusion product 1
chr24_-_32408404 1.98 ENSDART00000144157
si:ch211-56a11.2
chr19_+_7567763 1.96 ENSDART00000140411
S100 calcium binding protein A11
chr13_+_111212 1.96 ENSDART00000167840
dynein, axonemal, assembly factor 2
chr14_-_52542928 1.95 ENSDART00000075749
protein phosphatase 2, regulatory subunit B, beta a
chr1_-_10806625 1.95 ENSDART00000139749
si:ch73-222h13.1
chr4_-_390431 1.94 ENSDART00000067482
ENSDART00000138500
dynein, light chain, Tctex-type 1
chr8_-_32803227 1.94 ENSDART00000110079
zgc:194839
chr25_+_13731542 1.94 ENSDART00000161012
coiled-coil domain containing 135
chr5_-_57920600 1.91 ENSDART00000132376
si:dkey-27p23.3
chr6_+_120181 1.87 ENSDART00000151209
ENSDART00000185930
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr9_-_3671911 1.86 ENSDART00000102900
Sp5 transcription factor a
chr7_+_41295974 1.85 ENSDART00000173568
ENSDART00000173544
si:dkey-86l18.10
chr1_-_45633955 1.85 ENSDART00000044057
septin 3
chr15_-_19669770 1.84 ENSDART00000152707
si:dkey-4p15.3
chr3_-_61181018 1.83 ENSDART00000187970
parvalbumin 4
chr21_-_17956416 1.83 ENSDART00000026737
syntaxin 2a
chr21_-_22828593 1.83 ENSDART00000150993
angiopoietin-like 5
chr17_-_53440284 1.82 ENSDART00000126976
c-myc binding protein
chr5_-_54672763 1.81 ENSDART00000159009
sperm associated antigen 8
chr7_+_22675475 1.81 ENSDART00000134423
plac8 onzin related protein 3
chr2_+_6126638 1.80 ENSDART00000153916
fizzy/cell division cycle 20 related 1b
chr15_+_44053244 1.79 ENSDART00000059550
leucine rich repeat containing 51
chr17_+_53250802 1.79 ENSDART00000143819
vasohibin 1
chr21_-_17956739 1.78 ENSDART00000148154
syntaxin 2a
chr24_-_2917540 1.77 ENSDART00000164776
family with sequence similarity 69, member C
chr3_-_6767440 1.76 ENSDART00000156174
microtubule associated serine/threonine kinase 1b
chr6_+_13933464 1.75 ENSDART00000109144
protein tyrosine phosphatase, receptor type, Nb
chr21_+_41743493 1.75 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr22_-_16494406 1.71 ENSDART00000062727
syntaxin 6
chr2_-_30659222 1.70 ENSDART00000145405
catenin (cadherin-associated protein), delta 2b
chr3_-_52644737 1.70 ENSDART00000126180
si:dkey-210j14.3
chr10_+_37145007 1.68 ENSDART00000131777
CUE domain containing 1a
chr10_-_29744921 1.68 ENSDART00000088605
intraflagellar transport 46 homolog (Chlamydomonas)
chr11_-_97817 1.67 ENSDART00000092903
engulfment and cell motility 2
chr18_+_46382484 1.67 ENSDART00000024202
ENSDART00000142790
dynein assembly factor with WDR repeat domains 1
chr14_-_36799280 1.66 ENSDART00000168615
ring finger protein 130
chr10_-_35542071 1.63 ENSDART00000162139
si:ch211-244c8.4
chr18_+_34601023 1.61 ENSDART00000149647
TCDD-inducible poly(ADP-ribose) polymerase
chr6_+_7250824 1.61 ENSDART00000177226
DAZ interacting zinc finger protein 1
chr8_-_25338709 1.60 ENSDART00000131616
ATP synthase peripheral stalk-membrane subunit b
chr13_-_49819027 1.59 ENSDART00000067824
beta-1,3-N-acetylgalactosaminyltransferase 2
chr8_-_20380750 1.59 ENSDART00000113910
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr10_-_9410068 1.58 ENSDART00000041382
MORN repeat containing 5
chr19_-_4023050 1.58 ENSDART00000162883
sperm-tail PG-rich repeat containing 1
chr23_+_43950674 1.58 ENSDART00000167813
corin, serine peptidase
chr6_+_47424266 1.57 ENSDART00000171087
si:ch211-286o17.1
chr1_-_56223913 1.56 ENSDART00000019573
zgc:65894
chr10_-_22797959 1.55 ENSDART00000183269
procollagen C-endopeptidase enhancer a
chr16_+_221739 1.55 ENSDART00000180243
neurensin 1
chr19_-_103289 1.54 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr2_-_14271874 1.53 ENSDART00000189390
Tctex1 domain containing 1
chr3_+_31945604 1.52 ENSDART00000114957
zgc:193811
chr15_-_31177324 1.51 ENSDART00000008854
WD repeat and SOCS box containing 1
chr20_-_32270866 1.49 ENSDART00000153140
armadillo repeat containing 2
chr9_-_327901 1.47 ENSDART00000159956
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2a
chr13_+_33246150 1.47 ENSDART00000136356
ENSDART00000132834
ENSDART00000144379
ENSDART00000131985
ENSDART00000148368
ENSDART00000035940
ENSDART00000141912
NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
chr16_-_50175069 1.42 ENSDART00000192979
lens intrinsic membrane protein 2.5
chr6_-_33023745 1.42 ENSDART00000156211
adenylate cyclase activating polypeptide 1b (pituitary) receptor type I
chr8_-_53488832 1.42 ENSDART00000191801
choline dehydrogenase
chr22_+_2937485 1.41 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
centrosomal protein 19
chr21_-_22709251 1.41 ENSDART00000140032
si:dkeyp-69c1.9
chr24_+_17269849 1.40 ENSDART00000017605
sperm associated antigen 6
chr15_-_20939579 1.40 ENSDART00000152371
ubiquitin specific peptidase 2a
chr5_-_42661012 1.40 ENSDART00000158339
Pim proto-oncogene, serine/threonine kinase, related 58
chr2_-_14272083 1.39 ENSDART00000169986
Tctex1 domain containing 1
chr19_-_40186328 1.39 ENSDART00000087474
EF-hand calcium binding domain 1
chr10_-_17231917 1.39 ENSDART00000038577
RAB36, member RAS oncogene family
chr4_+_77971104 1.39 ENSDART00000188609
zgc:113921
chr6_+_3816241 1.38 ENSDART00000178545
glutamate-rich 2
chr4_-_42242844 1.38 ENSDART00000163476
si:ch211-129p6.2
chr20_+_52458765 1.38 ENSDART00000057980
tissue specific transplantation antigen P35B
chr16_+_46492994 1.38 ENSDART00000134734
rapunzel 5
chr25_+_13731726 1.38 ENSDART00000181065
coiled-coil domain containing 135
chr25_-_28638052 1.37 ENSDART00000138918
ENSDART00000135247
ENSDART00000114662
ENSDART00000157493
ENSDART00000137677
ATP/GTP binding protein-like 2
chr20_+_27691307 1.36 ENSDART00000153299
si:dkey-1h6.8
chr16_+_4497302 1.34 ENSDART00000081826
ENSDART00000148096
tetratricopeptide repeat domain 29
chr4_-_13626831 1.33 ENSDART00000173077
si:dkeyp-81f3.4
chr4_+_3980247 1.32 ENSDART00000049194
G protein-coupled receptor 37b
chr10_+_9410304 1.31 ENSDART00000080843
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
chr1_+_37391716 1.30 ENSDART00000191986
SPARC-like 1
chr2_+_47581997 1.29 ENSDART00000112579
secretogranin II (chromogranin C), b
chr25_-_25736958 1.29 ENSDART00000166308
calcium and integrin binding family member 2
chr19_+_5318358 1.29 ENSDART00000082133
si:dkeyp-113d7.1
chr17_-_39779906 1.29 ENSDART00000155181
Pim proto-oncogene, serine/threonine kinase, related 61
chr5_-_57652168 1.28 ENSDART00000166245
expressed sequence EH456644
chr19_-_12324514 1.27 ENSDART00000122192
neurocalcin delta b
chr20_-_43775495 1.27 ENSDART00000100610
ENSDART00000149001
ENSDART00000148809
ENSDART00000100608
matrilin 3a
chr2_-_197665 1.27 ENSDART00000169743

chr9_-_31747106 1.26 ENSDART00000048469
ENSDART00000145204
ENSDART00000186889
sodium leak channel, non-selective
chr4_-_8611841 1.25 ENSDART00000067322
F-box and leucine-rich repeat protein 14b
chr5_-_8406192 1.23 ENSDART00000159718
sperm flagellar 2
chr19_-_1405363 1.22 ENSDART00000165516
cilia and flagella associated protein 20
chr17_-_53439866 1.21 ENSDART00000154826
c-myc binding protein
chr17_-_40397752 1.21 ENSDART00000178483

chr11_-_11518469 1.20 ENSDART00000104254
keratin 15
chr1_+_10720294 1.18 ENSDART00000139387
ATPase Na+/K+ transporting subunit beta 1b
chr11_+_36477481 1.17 ENSDART00000128245
low density lipoprotein receptor class A domain containing 2
chr22_+_16418688 1.17 ENSDART00000009360
ankyrin repeat domain 29
chr24_+_17270129 1.17 ENSDART00000186729
sperm associated antigen 6
chr9_-_6927587 1.17 ENSDART00000059092
transmembrane protein 182a
chr4_-_9586713 1.16 ENSDART00000145613
SH3 and multiple ankyrin repeat domains 3b
chr5_+_64732036 1.16 ENSDART00000073950
olfactomedin 1a
chr14_-_25042184 1.16 ENSDART00000131027
si:rp71-1d10.5
chr8_+_26522013 1.15 ENSDART00000046863
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl
chr9_+_9441453 1.14 ENSDART00000081859
ENSDART00000188567
ENSDART00000143101
MYCBP-associated, testis expressed 1
chr21_+_39292266 1.14 ENSDART00000144116
si:ch211-274p24.2
chr5_+_42400777 1.13 ENSDART00000183114

chr9_+_17309195 1.13 ENSDART00000048548
sciellin
chr8_+_2487883 1.12 ENSDART00000101841
dynein, light chain, LC8-type 1
chr17_-_44249720 1.12 ENSDART00000156648
orthodenticle homeobox 2b
chr15_+_33865312 1.12 ENSDART00000166141
tektin 1
chr5_-_23317477 1.11 ENSDART00000090171
neuroligin 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx3_rfx2+rfx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
1.0 2.9 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.9 4.7 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.9 8.5 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.8 2.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.7 4.7 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.6 3.0 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.6 3.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 11.1 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 1.4 GO:0019695 choline metabolic process(GO:0019695)
0.4 2.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.4 19.3 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.4 1.5 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.4 2.6 GO:0007288 sperm axoneme assembly(GO:0007288)
0.3 1.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 4.7 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.3 3.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.3 0.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 1.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 2.1 GO:0032475 otolith formation(GO:0032475)
0.3 1.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.3 0.8 GO:1902176 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) regulation of apoptotic cell clearance(GO:2000425)
0.3 1.8 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.3 1.0 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.2 1.4 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 3.3 GO:0030317 sperm motility(GO:0030317)
0.2 2.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 3.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 2.2 GO:0044458 motile cilium assembly(GO:0044458)
0.2 8.0 GO:0030199 collagen fibril organization(GO:0030199)
0.2 1.0 GO:0061011 hepatic duct development(GO:0061011)
0.2 2.9 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 2.0 GO:0001881 receptor recycling(GO:0001881)
0.2 2.8 GO:0036065 fucosylation(GO:0036065)
0.2 1.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 1.6 GO:1902110 positive regulation of mitochondrial membrane permeability(GO:0035794) positive regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902110) mitochondrial outer membrane permeabilization involved in programmed cell death(GO:1902686)
0.2 2.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 1.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.2 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 1.0 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.7 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 1.7 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 1.1 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 3.6 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.4 GO:0060437 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.1 8.7 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.1 0.9 GO:0019405 alditol catabolic process(GO:0019405)
0.1 0.8 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 5.3 GO:0003341 cilium movement(GO:0003341)
0.1 2.6 GO:0001649 osteoblast differentiation(GO:0001649)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.3 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 4.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 1.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 1.4 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.6 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 3.1 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.1 4.6 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 0.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 1.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 2.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.1 2.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 0.6 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.1 1.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 2.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.8 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.1 0.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 0.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 1.4 GO:0042073 intraciliary transport(GO:0042073)
0.1 1.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 0.6 GO:0050796 regulation of insulin secretion(GO:0050796) hepatocyte differentiation(GO:0070365)
0.1 2.3 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.2 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.1 2.5 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 0.9 GO:0007398 ectoderm development(GO:0007398)
0.1 0.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.8 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.6 GO:0035094 response to nicotine(GO:0035094) response to alkaloid(GO:0043279)
0.0 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.0 2.5 GO:0022900 electron transport chain(GO:0022900)
0.0 0.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.5 GO:0032048 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.0 3.2 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 3.5 GO:0048916 posterior lateral line development(GO:0048916)
0.0 0.4 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.4 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 0.7 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 1.9 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 2.9 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 4.4 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 2.1 GO:0009306 protein secretion(GO:0009306)
0.0 1.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.4 GO:0021754 facial nucleus development(GO:0021754)
0.0 1.7 GO:0006909 phagocytosis(GO:0006909)
0.0 3.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.2 GO:1901490 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.0 1.2 GO:0016525 negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
0.0 1.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 3.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.1 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.2 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579) positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.5 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.4 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 7.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.2 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.3 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 2.2 GO:0030900 forebrain development(GO:0030900)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.8 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 1.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0010574 vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574) positive regulation of vascular endothelial growth factor production(GO:0010575) esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0015740 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) C4-dicarboxylate transport(GO:0015740) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0001534 radial spoke(GO:0001534)
0.4 1.6 GO:0043073 germ cell nucleus(GO:0043073)
0.4 3.0 GO:0001772 immunological synapse(GO:0001772)
0.3 5.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.3 3.8 GO:1990246 uniplex complex(GO:1990246)
0.3 3.3 GO:0036157 outer dynein arm(GO:0036157)
0.3 11.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 0.9 GO:0097255 R2TP complex(GO:0097255)
0.2 1.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 2.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 1.2 GO:0097225 sperm midpiece(GO:0097225)
0.2 2.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 3.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 18.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 3.5 GO:0043195 terminal bouton(GO:0043195)
0.1 2.1 GO:0030315 T-tubule(GO:0030315)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 8.5 GO:0005581 collagen trimer(GO:0005581)
0.1 2.7 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 0.8 GO:0031526 brush border membrane(GO:0031526)
0.1 3.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 3.9 GO:0005814 centriole(GO:0005814)
0.0 2.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.4 GO:0030141 secretory granule(GO:0030141)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.6 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 9.5 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.3 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.7 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 3.3 GO:0016604 nuclear body(GO:0016604)
0.0 6.7 GO:0005874 microtubule(GO:0005874)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 3.1 GO:0005764 lysosome(GO:0005764)
0.0 13.4 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.1 5.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.7 2.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.6 3.0 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.4 5.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.3 1.8 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.3 4.6 GO:0005080 protein kinase C binding(GO:0005080)
0.3 5.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 0.8 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 2.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 2.7 GO:0045503 dynein light chain binding(GO:0045503)
0.2 1.0 GO:0039706 co-receptor binding(GO:0039706)
0.2 1.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 2.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 1.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 5.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 2.8 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 6.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.0 GO:0031386 protein tag(GO:0031386)
0.1 0.8 GO:0001727 lipid kinase activity(GO:0001727)
0.1 2.1 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 3.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 8.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 5.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 3.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 3.6 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 8.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 26.6 GO:0005198 structural molecule activity(GO:0005198)
0.1 2.1 GO:0051087 chaperone binding(GO:0051087)
0.1 2.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.4 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.1 GO:0051393 actinin binding(GO:0042805) muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 1.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.5 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0005119 smoothened binding(GO:0005119)
0.0 2.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.6 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 2.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 1.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 6.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 13.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0016208 AMP binding(GO:0016208)
0.0 1.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 22.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 6.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 1.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.1 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.9 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 0.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID IFNG PATHWAY IFN-gamma pathway
0.0 3.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 22.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.5 2.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 5.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 2.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.4 5.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 5.3 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.3 5.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 11.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 1.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 0.8 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 4.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling