ISMARA results: rest

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PRJNA195909:zebrafish embryo and larva development

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Results for rest

Z-value: 6.93

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Transcription factors associated with rest

Gene Symbol	Gene ID	Gene Info
rest NCBI UniProt	ENSDARG00000103046	Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
rest	dr11_v1_chr14_-_52433292_52433292	-0.93	2.7e-04	Click!

Activity profile of rest motif

Sorted Z-values of rest motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_17676745 Show fit	22.01	ENSDART00000030665	slc25a4 NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr25_-_22639133 Show fit	19.10	ENSDART00000073583	islr2 NCBI UniProt Show fit	immunoglobulin superfamily containing leucine-rich repeat 2
chr20_+_34913069 Show fit	17.55	ENSDART00000007584	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr21_+_6751405 Show fit	15.73	ENSDART00000037265 ENSDART00000146371	olfm1b NCBI UniProt Show fit	olfactomedin 1b
chr21_+_6751760 Show fit	15.55	ENSDART00000135914	olfm1b NCBI UniProt Show fit	olfactomedin 1b
chr17_-_12385308 Show fit	14.31	ENSDART00000080927	snap25b NCBI UniProt Show fit	synaptosomal-associated protein, 25b
chr1_+_10720294 Show fit	13.29	ENSDART00000139387	atp1b1b NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit beta 1b
chr21_+_11468934 Show fit	13.00	ENSDART00000126045 ENSDART00000129744 ENSDART00000102368	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr7_+_23907692 Show fit	12.70	ENSDART00000045479	syt4 NCBI UniProt Show fit	synaptotagmin IV
chr19_-_19339285 Show fit	12.23	ENSDART00000158413 ENSDART00000170479	cspg5b NCBI UniProt Show fit	chondroitin sulfate proteoglycan 5b

Showing 1 to 10 of 115 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	53.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.0	36.1	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
1.1	31.9	GO:0016082	synaptic vesicle priming(GO:0016082)
0.0	31.4	GO:0007399	nervous system development(GO:0007399)
0.8	24.7	GO:0007631	feeding behavior(GO:0007631)
5.5	22.0	GO:0015860	intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.5	20.5	GO:0014046	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
1.9	14.9	GO:0098700	neurotransmitter loading into synaptic vesicle(GO:0098700)
1.7	13.6	GO:0043090	amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.7	13.3	GO:0071436	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)

Showing 1 to 10 of 52 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	86.6	GO:0016021	integral component of membrane(GO:0016021)
0.0	49.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	44.4	GO:0045202	synapse(GO:0045202)
0.0	41.4	GO:0005615	extracellular space(GO:0005615)
2.4	36.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
5.3	31.9	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	22.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	19.2	GO:0099503	secretory vesicle(GO:0099503)
1.0	14.9	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.3	13.3	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	57.6	GO:0005509	calcium ion binding(GO:0005509)
0.0	36.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.8	36.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.8	31.9	GO:0017075	syntaxin-1 binding(GO:0017075)
5.5	22.0	GO:0005471	ATP:ADP antiporter activity(GO:0005471)
4.3	21.5	GO:0031843	neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.6	21.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.4	20.5	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	15.2	GO:0005179	hormone activity(GO:0005179)
1.1	14.9	GO:0005326	neurotransmitter transporter activity(GO:0005326)

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	8.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	4.1	PID RAS PATHWAY	Regulation of Ras family activation
0.1	3.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	1.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	22.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.9	13.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5	12.0	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.9	11.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	8.3	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.5	8.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.0	4.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6	3.9	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	2.6	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	1.1	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock

Showing 1 to 10 of 10 entries

Results for rest

Z-value: 6.93

Motif logo

Transcription factors associated with rest

Activity-expression correlation:

Activity profile of rest motif

Sorted Z-values of rest motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: