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PRJNA195909:zebrafish embryo and larva development
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Results for rbpjb
Z-value: 2.37
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Transcription factors associated with rbpjb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rbpjb | dr11_v1_chr7_+_62080456_62080456 | -0.81 | 7.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_41981959 Show fit | 6.77 |
ENSDART00000055707
|
hairy and enhancer of split-related 15, tandem duplicate 1 |
|
| chr1_+_44442140 Show fit | 5.56 |
ENSDART00000190592
|
crystallin, beta B1, like 2 |
|
| chr7_+_31891110 Show fit | 5.36 |
ENSDART00000173883
|
myosin binding protein C, cardiac |
|
| chr19_-_31802296 Show fit | 5.26 |
ENSDART00000103640
|
hes-related family bHLH transcription factor with YRPW motif 1 |
|
| chr9_-_22092089 Show fit | 5.07 |
ENSDART00000101928
|
crystallin, gamma M2d13 |
|
| chr24_-_37877743 Show fit | 4.89 |
ENSDART00000105658
|
transmembrane protein 204 |
|
| chr9_-_22205682 Show fit | 4.37 |
ENSDART00000101869
|
crystallin, gamma M2d12 |
|
| chr17_-_25326685 Show fit | 4.36 |
ENSDART00000082327
|
poly(A) binding protein, cytoplasmic 4 (inducible form) |
|
| chr19_+_42609132 Show fit | 4.18 |
ENSDART00000010104
|
cartilage associated protein |
|
| chr23_-_23401305 Show fit | 4.03 |
ENSDART00000078936
|
hairy-related 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of rbpjb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.0 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 17.3 | GO:0050767 | regulation of neurogenesis(GO:0050767) |
| 0.1 | 6.3 | GO:0050768 | negative regulation of neurogenesis(GO:0050768) |
| 0.1 | 5.8 | GO:0045103 | intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104) |
| 1.1 | 5.4 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.5 | 5.4 | GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043) |
| 0.2 | 4.2 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 1.0 | 4.0 | GO:0031448 | regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076) |
| 0.0 | 3.9 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.4 | 3.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 7.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 4.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 4.3 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.1 | 4.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.0 | 4.0 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 3.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 2.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 2.5 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 2.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 18.5 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.0 | 9.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.6 | 8.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 6.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 5.4 | GO:0016918 | retinal binding(GO:0016918) |
| 0.5 | 5.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 4.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 4.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 4.0 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 2.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 4.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 4.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 3.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 2.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |