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PRJNA195909:zebrafish embryo and larva development
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Results for prrx1a+prrx1b
Z-value: 2.05
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Transcription factors associated with prrx1a+prrx1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| prrx1a | dr11_v1_chr2_-_23172708_23172708 | 0.88 | 1.5e-03 | Click! |
| prrx1b | dr11_v1_chr20_+_34512130_34512130 | 0.86 | 2.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_31276842 Show fit | 21.89 |
ENSDART00000187238
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr4_+_9669717 Show fit | 6.93 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr21_+_6556635 Show fit | 5.46 |
ENSDART00000139598
|
procollagen, type V, alpha 1 |
|
| chr3_+_28939759 Show fit | 4.70 |
ENSDART00000141904
|
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1 |
|
| chr16_+_23984755 Show fit | 4.25 |
ENSDART00000145328
|
apolipoprotein C-II |
|
| chr19_-_3167729 Show fit | 3.90 |
ENSDART00000110763
ENSDART00000145710 ENSDART00000074620 ENSDART00000105174 |
starmaker |
|
| chr25_+_31277415 Show fit | 3.79 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr16_-_21140097 Show fit | 3.69 |
ENSDART00000145837
ENSDART00000146500 |
si:dkey-271j15.3 |
|
| chr1_+_17676745 Show fit | 3.68 |
ENSDART00000030665
|
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
|
| chr9_-_22339582 Show fit | 3.58 |
ENSDART00000134805
|
crystallin, gamma M2d1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of prrx1a+prrx1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 28.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 5.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 1.0 | 3.9 | GO:0061549 | sympathetic ganglion development(GO:0061549) |
| 0.6 | 3.9 | GO:0045299 | otolith mineralization(GO:0045299) |
| 0.3 | 3.9 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.2 | 3.8 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.9 | 3.7 | GO:0015859 | intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544) |
| 0.3 | 3.7 | GO:0006285 | base-excision repair, AP site formation(GO:0006285) |
| 0.1 | 3.7 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.0 | 3.6 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 28.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.6 | 6.4 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 1.4 | 5.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 4.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 4.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 3.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.9 | GO:0005840 | ribosome(GO:0005840) |
| 0.2 | 2.6 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 2.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.3 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.7 | 6.8 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 6.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.5 | 5.4 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 5.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.9 | 3.7 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) |
| 0.4 | 3.7 | GO:0008263 | mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.0 | 3.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 2.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 5.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.7 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.5 | 3.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 2.1 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 2.1 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 2.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 2.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 1.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |