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PRJNA195909:zebrafish embryo and larva development

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Results for prrx1a+prrx1b

Z-value: 2.05

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Transcription factors associated with prrx1a+prrx1b

Gene Symbol Gene ID Gene Info
ENSDARG00000033971 paired related homeobox 1a
ENSDARG00000042027 paired related homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prrx1adr11_v1_chr2_-_23172708_231727080.881.5e-03Click!
prrx1bdr11_v1_chr20_+_34512130_345121300.862.6e-03Click!

Activity profile of prrx1a+prrx1b motif

Sorted Z-values of prrx1a+prrx1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_31276842 21.89 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr4_+_9669717 6.93 ENSDART00000004604
si:dkey-153k10.9
chr21_+_6556635 5.46 ENSDART00000139598
procollagen, type V, alpha 1
chr3_+_28939759 4.70 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr16_+_23984755 4.25 ENSDART00000145328
apolipoprotein C-II
chr19_-_3167729 3.90 ENSDART00000110763
ENSDART00000145710
ENSDART00000074620
ENSDART00000105174
starmaker
chr25_+_31277415 3.79 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr16_-_21140097 3.69 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
chr1_+_17676745 3.68 ENSDART00000030665
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr9_-_22339582 3.58 ENSDART00000134805
crystallin, gamma M2d1
chr20_+_31287356 3.46 ENSDART00000007688
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr16_-_31717851 3.33 ENSDART00000169109
retinol binding protein 1a, cellular
chr25_+_18964782 3.31 ENSDART00000017299
thymine DNA glycosylase, tandem duplicate 1
chr1_-_42289704 3.26 ENSDART00000150124
si:ch211-71k14.1
chr21_+_26390549 3.02 ENSDART00000185643
thymosin, beta
chr7_-_48667056 2.89 ENSDART00000006378
cyclin-dependent kinase inhibitor 1Ca
chr2_+_16781015 2.84 ENSDART00000155147
ENSDART00000003845
transferrin-a
chr10_-_28835771 2.76 ENSDART00000192220
ENSDART00000188436
activated leukocyte cell adhesion molecule a
chr10_+_32104305 2.73 ENSDART00000099880
wingless-type MMTV integration site family, member 11, related
chr1_-_30979707 2.72 ENSDART00000008469
distal-less homeobox 2b
chr21_+_27382893 2.71 ENSDART00000005682
actinin alpha 3a
chr16_-_31718013 2.70 ENSDART00000190716
retinol binding protein 1a, cellular
chr15_-_14884332 2.66 ENSDART00000165237
si:ch211-24o8.4
chr20_-_43775495 2.66 ENSDART00000100610
ENSDART00000149001
ENSDART00000148809
ENSDART00000100608
matrilin 3a
chr13_+_24279021 2.63 ENSDART00000058629
actin, alpha 1b, skeletal muscle
chr19_-_3240605 2.61 ENSDART00000105168
si:ch211-133n4.4
chr12_-_5728755 2.61 ENSDART00000105887
distal-less homeobox 4b
chr6_+_9130989 2.58 ENSDART00000162588
regucalcin
chr20_-_44496245 2.56 ENSDART00000012229
FK506 binding protein 1b
chr7_-_28148310 2.55 ENSDART00000044208
LIM domain only 1
chr16_-_45058919 2.53 ENSDART00000177134
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr1_-_40911332 2.50 ENSDART00000027463
H6 family homeobox 4
chr23_-_18913032 2.49 ENSDART00000136678
si:ch211-209j10.6
chr13_+_25449681 2.44 ENSDART00000101328
atonal bHLH transcription factor 7
chr14_-_17068511 2.39 ENSDART00000163766
paired-like homeobox 2bb
chr21_+_7582036 2.31 ENSDART00000135485
ENSDART00000027268
orthopedia homeobox a
chr12_-_990149 2.29 ENSDART00000054367
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr5_-_65037525 2.28 ENSDART00000158856
annexin A1b
chr7_+_26629084 2.28 ENSDART00000101044
ENSDART00000173765
heat shock factor binding protein 1a
chr18_-_47662696 2.28 ENSDART00000184260

chr23_+_45282858 2.26 ENSDART00000162353

chr18_+_5490668 2.23 ENSDART00000167035
muscle-specific beta 1 integrin binding protein 2
chr11_-_45138857 2.22 ENSDART00000166501
calcium activated nucleotidase 1b
chr25_+_29160102 2.18 ENSDART00000162854
pyruvate kinase M1/2b
chr17_+_30704068 2.15 ENSDART00000062793
apolipoprotein Ba
chr25_+_20089986 2.14 ENSDART00000143441
ENSDART00000184073
troponin I4b, tandem duplicate 2
chr6_+_23887314 2.10 ENSDART00000163188
zinc finger protein 648
chr20_-_27225876 2.08 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
chr3_+_28953274 2.07 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr21_+_13861589 2.06 ENSDART00000015629
ENSDART00000171306
syntaxin binding protein 1a
chr15_-_2640966 2.06 ENSDART00000063320
claudin e
chr10_-_26744131 2.01 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr2_+_56463167 2.00 ENSDART00000123392
RAB11B, member RAS oncogene family, b
chr14_-_24410673 1.99 ENSDART00000125923
chemokine (C-X-C motif) ligand 14
chr12_-_558201 1.98 ENSDART00000168586
ENSDART00000158355
brain specific kinase 146
chr2_+_38039857 1.97 ENSDART00000159951
calsequestrin 1a
chr22_-_23668356 1.96 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
complement factor H
chr9_-_1959917 1.95 ENSDART00000082359
homeobox D3a
chr4_-_9909371 1.95 ENSDART00000102656
si:dkey-22l11.6
chr24_-_21923930 1.91 ENSDART00000131944
transgelin 3b
chr8_-_14091886 1.90 ENSDART00000137857
si:ch211-229n2.7
chr14_-_34044369 1.86 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr12_+_15666949 1.85 ENSDART00000079803
N-myristoyltransferase 1b
chr12_-_30338779 1.84 ENSDART00000192511
von Willebrand factor A domain containing 2
chr7_-_30367650 1.84 ENSDART00000075519
aldehyde dehydrogenase 1 family, member A2
chr12_+_42436920 1.82 ENSDART00000177303
early B cell factor 3a
chr20_+_34320635 1.82 ENSDART00000153207
influenza virus NS1A binding protein a
chr9_+_34641237 1.80 ENSDART00000133996
short stature homeobox
chr24_+_22485710 1.77 ENSDART00000146058
si:dkey-40h20.1
chr5_-_31901468 1.76 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr24_-_38657683 1.74 ENSDART00000154843
si:ch1073-164k15.3
chr23_-_12345764 1.74 ENSDART00000133956
phosphatase and actin regulator 3a
chr8_+_41647539 1.73 ENSDART00000136492
ENSDART00000138799
ENSDART00000134404
si:ch211-158d24.4
chr4_-_16345227 1.73 ENSDART00000079521
keratocan
chr14_-_21123551 1.73 ENSDART00000171679
ENSDART00000165882
si:dkey-74k8.4
chr23_+_11285662 1.72 ENSDART00000111028
cell adhesion molecule L1-like a
chr8_+_15254564 1.72 ENSDART00000024433
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr12_+_18681477 1.68 ENSDART00000127981
ENSDART00000143979
regulator of G protein signaling 9b
chr12_+_42436328 1.65 ENSDART00000167324
early B cell factor 3a
chr9_-_34300707 1.64 ENSDART00000049805
immunoglobulin-like domain containing receptor 2
chr3_-_24980067 1.64 ENSDART00000048871
desumoylating isopeptidase 1a
chr13_-_31622195 1.63 ENSDART00000057432
SIX homeobox 1a
chr25_-_13381854 1.62 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr1_-_45049603 1.62 ENSDART00000023336
ribosomal protein S6
chr21_-_44104600 1.58 ENSDART00000044599
organic anion transporter X
chr6_+_52350443 1.55 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr22_-_10121880 1.54 ENSDART00000002348
retinol dehydrogenase 5 (11-cis/9-cis)
chr5_+_34407763 1.53 ENSDART00000188849
ENSDART00000145127
laminin, gamma 3
chr2_+_30916188 1.52 ENSDART00000137012
myomesin 1a (skelemin)
chr1_+_25801648 1.52 ENSDART00000129471
guanylate cyclase 1 soluble subunit beta 1
chr15_+_35043007 1.52 ENSDART00000086954
sestrin 3
chr22_-_32507966 1.51 ENSDART00000104693
poly(rC) binding protein 4
chr3_-_37759147 1.51 ENSDART00000151067
si:dkey-260c8.6
chr15_-_21165237 1.50 ENSDART00000157069
si:ch211-212c13.8
chr9_-_21918963 1.50 ENSDART00000090782
LIM domain 7a
chr7_-_17028015 1.49 ENSDART00000022441
developing brain homeobox 1a
chr14_-_17068712 1.47 ENSDART00000170277
paired-like homeobox 2bb
chr19_+_31771270 1.46 ENSDART00000147474
stathmin 2b
chr7_-_69636502 1.46 ENSDART00000126739
tetraspanin 5a
chr21_-_37973819 1.45 ENSDART00000133405
ripply transcriptional repressor 1
chr18_+_17611627 1.45 ENSDART00000046891
cholesteryl ester transfer protein, plasma
chr10_-_36808348 1.45 ENSDART00000099320
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 1
chr24_+_21346796 1.45 ENSDART00000126519
shisa family member 2b
chr6_-_8311044 1.45 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr14_-_49063157 1.43 ENSDART00000021260
septin 8b
chr15_-_17813680 1.43 ENSDART00000158556

chr7_+_21859337 1.41 ENSDART00000159626
si:dkey-85k7.7
chr8_+_3085120 1.41 ENSDART00000148020
ENSDART00000136250
LIM homeobox 2b
chr1_-_669717 1.39 ENSDART00000160564
cysteine/tyrosine-rich 1
chr21_+_26720803 1.38 ENSDART00000053797
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr5_-_57655092 1.38 ENSDART00000074290
melanoma inhibitory activity
chr20_-_30920356 1.37 ENSDART00000022951
kinesin family member 25
chr18_-_46256560 1.36 ENSDART00000171375
si:dkey-244a7.1
chr12_+_10631266 1.34 ENSDART00000161455
colony stimulating factor 3 (granulocyte) a
chr12_+_316238 1.33 ENSDART00000187492
recoverin b
chr24_-_23942722 1.33 ENSDART00000080810
aristaless related homeobox a
chr3_+_12440099 1.30 ENSDART00000158060
vasorin b
chr13_+_30903816 1.30 ENSDART00000191727
excision repair cross-complementation group 6
chr4_-_16001118 1.30 ENSDART00000041070
ENSDART00000125389
mesoderm specific transcript
chr15_-_44512461 1.29 ENSDART00000155456
glutamate receptor, ionotropic, AMPA 4a
chr22_-_24284447 1.28 ENSDART00000149894
si:ch211-117l17.4
chr1_-_52494122 1.26 ENSDART00000131407
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr25_+_5044780 1.26 ENSDART00000153980
parvin, beta
chr20_-_7072487 1.25 ENSDART00000145954
si:ch211-121a2.2
chr6_+_6924637 1.25 ENSDART00000065551
ENSDART00000151393
sterile alpha motif and leucine zipper containing kinase AZK
chr25_-_15040369 1.25 ENSDART00000159342
ENSDART00000166490
paired box 6a
chr3_-_30158395 1.23 ENSDART00000103502
si:ch211-152f23.5
chr4_+_6032640 1.23 ENSDART00000157487
transcription factor EC
chr24_-_7697274 1.22 ENSDART00000186077
synaptotagmin Vb
chr22_+_9872323 1.22 ENSDART00000129240
si:dkey-253d23.4
chr7_+_15872357 1.22 ENSDART00000165757
paired box 6b
chr19_+_10339538 1.20 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr7_+_25858380 1.20 ENSDART00000148780
ENSDART00000079218
myotubularin related protein 1a
chr4_+_72723304 1.20 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
RAB3A interacting protein (rabin3)
chr23_+_26733232 1.20 ENSDART00000035080
zgc:158263
chr8_+_2487250 1.19 ENSDART00000081325
dynein, light chain, LC8-type 1
chr11_+_27543093 1.18 ENSDART00000023889
BARX homeobox 1
chr6_+_37894220 1.16 ENSDART00000087311
oculocutaneous albinism II
chr23_+_28770225 1.16 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr22_-_910926 1.16 ENSDART00000180075

chr24_+_25069609 1.15 ENSDART00000115165
APC membrane recruitment protein 2
chr16_+_31921812 1.15 ENSDART00000176928
ENSDART00000193733
ribosomal protein S9
chr1_-_10647484 1.12 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
chr4_-_4834347 1.12 ENSDART00000141803
cytochrome c oxidase assembly factor 6
chr7_+_66822229 1.12 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr20_-_22476255 1.11 ENSDART00000103510
platelet-derived growth factor receptor, alpha polypeptide
chr17_-_37214196 1.10 ENSDART00000128715
kinesin family member 3Cb
chr11_-_42554290 1.10 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr24_-_17067284 1.10 ENSDART00000111237
armadillo repeat containing 3
chr4_-_28373909 1.09 ENSDART00000056132
Tp53rk binding protein
chr19_-_28130658 1.08 ENSDART00000079114
iroquois homeobox 1b
chr14_-_4145594 1.08 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr24_-_38384432 1.08 ENSDART00000140739
leucine rich repeat containing 4Bb
chr19_+_9174166 1.07 ENSDART00000104637
ENSDART00000150968
si:ch211-81a5.8
chr5_-_51484156 1.07 ENSDART00000162064

chr11_-_3860534 1.06 ENSDART00000082425
GATA binding protein 2a
chr16_-_27174373 1.06 ENSDART00000166681
ferric-chelate reductase 1-like
chr2_-_30135446 1.06 ENSDART00000141906
transient receptor potential cation channel, subfamily A, member 1a
chr1_+_37391141 1.06 ENSDART00000083593
ENSDART00000168647
SPARC-like 1
chr7_+_56098590 1.05 ENSDART00000098453
cadherin 15, type 1, M-cadherin (myotubule)
chr23_+_45584223 1.05 ENSDART00000149367
si:ch73-290k24.5
chr14_+_11430796 1.04 ENSDART00000165275
si:ch211-153b23.3
chr15_-_17869115 1.04 ENSDART00000112838
activating transcription factor 5b
chr18_-_16801033 1.04 ENSDART00000100100
adrenomedullin b
chr25_+_34641536 1.03 ENSDART00000167033

chr3_-_32337653 1.03 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
chr1_-_50859053 1.03 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr15_-_35246742 1.03 ENSDART00000131479
mitochondrial fission factor
chr7_+_20147202 1.02 ENSDART00000011398
si:ch73-335l21.1
chr8_-_38477817 1.01 ENSDART00000075989
inositol polyphosphate-5-phosphatase L
chr1_-_46706639 1.01 ENSDART00000074519
karyopherin alpha 3 (importin alpha 4)
chr17_+_38476300 1.01 ENSDART00000123298
StAR-related lipid transfer (START) domain containing 9
chr17_+_18117029 1.01 ENSDART00000154646
ENSDART00000179739
B cell CLL/lymphoma 11Ba
chr13_+_30228077 1.00 ENSDART00000100813
ENSDART00000147729
ENSDART00000133404
ribosomal protein S24
chr10_+_5414224 0.99 ENSDART00000138821
nuclear factor, interleukin 3 regulated
chr4_-_77432218 0.99 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr20_-_8094718 0.99 ENSDART00000122902
si:ch211-232i5.3
chr20_+_5106568 0.98 ENSDART00000028039
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1
chr10_-_31440500 0.98 ENSDART00000024778
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr2_-_10188598 0.98 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr2_-_9489611 0.97 ENSDART00000146715
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr24_+_9475809 0.96 ENSDART00000132688
si:ch211-285f17.1
chr16_+_22654481 0.96 ENSDART00000179762
cholinergic receptor, nicotinic, beta 2b
chr1_+_23784905 0.94 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit homolog 2 (Drosophila)
chr15_+_19797918 0.94 ENSDART00000113314
si:ch211-229d2.5
chr19_+_37701450 0.94 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr20_-_9462433 0.94 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr15_-_17868870 0.93 ENSDART00000170950
activating transcription factor 5b
chr18_-_21271373 0.93 ENSDART00000060001
purine nucleoside phosphorylase 6
chr18_-_15932704 0.92 ENSDART00000127769
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr17_-_26926577 0.91 ENSDART00000050202
regulator of calcineurin 3
chr6_+_43426599 0.91 ENSDART00000056457
microphthalmia-associated transcription factor a
chr1_-_10647307 0.90 ENSDART00000103548
si:dkey-31e10.1
chr5_+_40224938 0.90 ENSDART00000142897
si:dkey-193c22.2
chr25_+_31227747 0.90 ENSDART00000033872
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr18_-_8885792 0.89 ENSDART00000143619
si:dkey-95h12.1
chr1_-_46981134 0.89 ENSDART00000130607
pbx/knotted 1 homeobox 1.2
chr4_-_390431 0.89 ENSDART00000067482
ENSDART00000138500
dynein, light chain, Tctex-type 1
chr10_-_10607118 0.88 ENSDART00000101089
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr5_+_48683447 0.88 ENSDART00000008043
adhesion G protein-coupled receptor V1

Network of associatons between targets according to the STRING database.

First level regulatory network of prrx1a+prrx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0061549 sympathetic ganglion development(GO:0061549)
0.9 3.7 GO:0015859 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.9 2.6 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.9 2.6 GO:0019852 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364)
0.8 2.4 GO:0015695 organic cation transport(GO:0015695)
0.8 3.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 2.0 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.6 1.8 GO:0006499 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.6 28.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.6 3.9 GO:0045299 otolith mineralization(GO:0045299)
0.5 1.5 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.5 1.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.4 2.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.4 2.9 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.4 1.6 GO:0014857 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.4 2.8 GO:0019731 antibacterial humoral response(GO:0019731)
0.4 1.2 GO:2000648 positive regulation of stem cell proliferation(GO:2000648)
0.4 2.3 GO:0021767 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.4 2.3 GO:2001279 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) myoblast migration involved in skeletal muscle regeneration(GO:0014839) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) myoblast migration(GO:0051451) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.4 1.9 GO:0070292 N-acylphosphatidylethanolamine metabolic process(GO:0070292)
0.4 1.5 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.4 0.7 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.4 1.4 GO:0015871 choline transport(GO:0015871)
0.4 1.1 GO:1902893 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.3 1.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 2.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 0.9 GO:0007414 axonal defasciculation(GO:0007414)
0.3 3.7 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.3 1.5 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.3 2.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 1.8 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.3 0.9 GO:0046333 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.3 0.9 GO:0097264 self proteolysis(GO:0097264)
0.3 1.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 1.1 GO:0050960 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.3 3.9 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.3 2.1 GO:0090303 positive regulation of wound healing(GO:0090303)
0.3 1.5 GO:0009110 vitamin biosynthetic process(GO:0009110)
0.2 1.4 GO:0071632 optomotor response(GO:0071632)
0.2 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.2 1.1 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.2 1.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.2 1.5 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.2 3.8 GO:0051764 actin crosslink formation(GO:0051764)
0.2 2.5 GO:0030656 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.2 2.3 GO:0034605 cellular response to heat(GO:0034605)
0.2 1.8 GO:0044550 secondary metabolite biosynthetic process(GO:0044550)
0.2 1.2 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.2 1.2 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.2 1.2 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.2 1.0 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 0.9 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.2 0.7 GO:0060092 inhibitory postsynaptic potential(GO:0060080) regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 0.3 GO:0046635 positive regulation of alpha-beta T cell activation(GO:0046635)
0.2 0.5 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.1 2.0 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 5.5 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.8 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.1 1.9 GO:0001964 startle response(GO:0001964)
0.1 0.4 GO:0021559 trigeminal nerve development(GO:0021559)
0.1 1.5 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 1.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 2.0 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 1.2 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 0.9 GO:0042554 superoxide anion generation(GO:0042554)
0.1 0.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.3 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 1.9 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.1 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 1.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.3 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:2001046 positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.1 2.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 2.2 GO:0070831 basement membrane assembly(GO:0070831)
0.1 1.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 1.5 GO:0042574 retinal metabolic process(GO:0042574)
0.1 1.4 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.7 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 1.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.0 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 1.6 GO:0010883 regulation of lipid storage(GO:0010883)
0.1 2.8 GO:0060536 cartilage morphogenesis(GO:0060536)
0.1 3.7 GO:0006096 glycolytic process(GO:0006096)
0.1 2.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.2 GO:0007398 ectoderm development(GO:0007398)
0.1 0.5 GO:0046959 learning(GO:0007612) nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 0.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 2.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.7 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.8 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.6 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.8 GO:0006825 copper ion transport(GO:0006825)
0.0 0.9 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.1 GO:0001774 microglial cell activation(GO:0001774)
0.0 0.6 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 2.1 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 1.6 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 1.8 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.7 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0 0.2 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.0 0.4 GO:0048641 regulation of skeletal muscle tissue development(GO:0048641)
0.0 0.4 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 2.6 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.6 GO:0032981 mitochondrial electron transport, NADH to ubiquinone(GO:0006120) NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 3.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 1.1 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.9 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.9 GO:0033339 pectoral fin development(GO:0033339)
0.0 1.1 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 0.3 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.3 GO:0010717 regulation of epithelial to mesenchymal transition(GO:0010717)
0.0 1.5 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.9 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 1.7 GO:0007492 endoderm development(GO:0007492)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0050802 circadian sleep/wake cycle process(GO:0022410) melatonin metabolic process(GO:0030186) circadian sleep/wake cycle(GO:0042745) regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) circadian sleep/wake cycle, sleep(GO:0050802)
0.0 0.5 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0030431 sleep(GO:0030431)
0.0 0.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.0 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 1.1 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.6 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.0 GO:0060326 cell chemotaxis(GO:0060326)
0.0 1.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.5 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.3 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 1.5 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0099558 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558) presynaptic active zone organization(GO:1990709)
0.0 0.3 GO:0033334 fin morphogenesis(GO:0033334)
0.0 1.7 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 1.0 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.4 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 0.3 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 1.1 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0005588 collagen type V trimer(GO:0005588)
0.7 28.8 GO:0005861 troponin complex(GO:0005861)
0.6 6.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.3 1.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.3 2.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 0.9 GO:0060171 stereocilium membrane(GO:0060171)
0.2 1.5 GO:0061700 GATOR2 complex(GO:0061700)
0.2 1.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.2 0.5 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.2 2.6 GO:0005869 dynactin complex(GO:0005869)
0.2 0.6 GO:0070195 growth hormone receptor complex(GO:0070195)
0.2 1.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 1.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.1 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.1 0.4 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 1.9 GO:0043195 terminal bouton(GO:0043195)
0.1 4.3 GO:0030426 growth cone(GO:0030426)
0.1 0.7 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.1 1.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 4.4 GO:0055037 recycling endosome(GO:0055037)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0035060 brahma complex(GO:0035060)
0.0 0.3 GO:0014704 intercalated disc(GO:0014704)
0.0 1.0 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.8 GO:0030141 secretory granule(GO:0030141)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0043679 axon terminus(GO:0043679)
0.0 2.0 GO:0030018 Z disc(GO:0030018)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.9 GO:0005840 ribosome(GO:0005840)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.0 GO:0031417 NatC complex(GO:0031417)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.8 2.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.7 6.8 GO:0016936 galactoside binding(GO:0016936)
0.6 1.9 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 2.5 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.6 1.8 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.5 5.4 GO:0016918 retinal binding(GO:0016918)
0.4 3.7 GO:0008263 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.4 1.2 GO:0001729 ceramide kinase activity(GO:0001729)
0.4 2.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 2.3 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.4 2.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 2.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 1.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.3 2.2 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.3 0.9 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.3 3.5 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.3 1.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 1.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 2.1 GO:0070325 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.2 0.7 GO:0031716 calcitonin receptor binding(GO:0031716)
0.2 1.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.5 GO:0070728 leucine binding(GO:0070728)
0.2 1.0 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.7 GO:0072571 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.2 0.5 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.2 1.0 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.2 0.6 GO:0004903 growth hormone receptor activity(GO:0004903)
0.2 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 3.0 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.6 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.1 1.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.5 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 1.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 1.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.3 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.0 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.1 2.7 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 0.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.5 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 1.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.0 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 2.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 6.8 GO:0008201 heparin binding(GO:0008201)
0.1 0.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.5 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 1.0 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.5 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.7 GO:0010851 cyclase regulator activity(GO:0010851)
0.1 0.3 GO:0015288 porin activity(GO:0015288)
0.1 1.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.8 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 0.5 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 1.1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.7 GO:2001069 glycogen binding(GO:2001069)
0.0 0.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 3.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0051117 ATPase binding(GO:0051117)
0.0 3.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 2.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 2.0 GO:0008009 chemokine activity(GO:0008009)
0.0 0.4 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.6 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 1.0 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.4 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 33.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 5.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 1.7 GO:0001664 G-protein coupled receptor binding(GO:0001664)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.2 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 2.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 3.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.5 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 1.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 1.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 5.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.7 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.1 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.9 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import