ISMARA results: prdm4

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PRJNA195909:zebrafish embryo and larva development

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Results for prdm4

Z-value: 0.34

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Transcription factors associated with prdm4

Gene Symbol	Gene ID	Gene Info
prdm4 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000017366	PR domain containing 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
prdm4	dr11_v1_chr4_-_14926637_14926637	0.77	1.6e-02	Click!

Activity profile of prdm4 motif

Sorted Z-values of prdm4 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_31621774 Show fit	1.55	ENSDART00000076636	fzd2 NCBI UniProt ZFIN ENSEMBL Google Show fit	frizzled class receptor 2
chr9_-_13355071 Show fit	0.90	ENSDART00000084055	fzd7a NCBI UniProt ZFIN ENSEMBL Google Show fit	frizzled class receptor 7a
chr23_-_24682244 Show fit	0.82	ENSDART00000104035	ctdsp2 NCBI UniProt ZFIN ENSEMBL Google Show fit	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr10_-_3332362 Show fit	0.57	ENSDART00000007577 ENSDART00000055140	tor4aa NCBI UniProt ZFIN ENSEMBL Google Show fit	torsin family 4, member Aa
chr20_-_26001288 Show fit	0.19	ENSDART00000136518 ENSDART00000063177	capn3b NCBI UniProt ZFIN ENSEMBL Google Show fit	calpain 3b
chr3_+_32425202 Show fit	0.17	ENSDART00000156464	prr12b NCBI UniProt ZFIN ENSEMBL Google Show fit	proline rich 12b
chr3_+_25999477 Show fit	0.15	ENSDART00000024316	mcm5 NCBI UniProt ZFIN ENSEMBL Google Show fit	minichromosome maintenance complex component 5
chr19_+_2670130 Show fit	0.14	ENSDART00000152152	si:ch73-24k9.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-24k9.2
chr22_-_21046654 Show fit	0.13	ENSDART00000064902	ssbp4 NCBI UniProt ZFIN ENSEMBL Google Show fit	single stranded DNA binding protein 4
chr22_-_21046843 Show fit	0.12	ENSDART00000133982	ssbp4 NCBI UniProt ZFIN ENSEMBL Google Show fit	single stranded DNA binding protein 4
chr9_+_15893093 Show fit	0.11	ENSDART00000099483 ENSDART00000134657	si:dkey-14o1.20 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-14o1.20
chrM_+_9735 Show fit	0.09	ENSDART00000093613	mt-co3 NCBI UniProt ZFIN ENSEMBL Google Show fit	cytochrome c oxidase III, mitochondrial
chr20_-_45709990 Show fit	0.09	ENSDART00000027482	gpcpd1 NCBI UniProt ZFIN ENSEMBL Google Show fit	glycerophosphocholine phosphodiesterase 1
chr17_+_31611854 Show fit	0.07	ENSDART00000011706	adprhl2 NCBI UniProt ZFIN ENSEMBL Google Show fit	ADP-ribosylhydrolase like 2
chr20_-_42203629 Show fit	0.05	ENSDART00000074959	slc35f1 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 35, member F1
chr5_+_27442247 Show fit	0.05	ENSDART00000184129	loxl2b NCBI UniProt ZFIN ENSEMBL Google Show fit	lysyl oxidase-like 2b
chr8_+_20679759 Show fit	0.02	ENSDART00000088668	nfic NCBI UniProt ZFIN ENSEMBL Google Show fit	nuclear factor I/C
chr9_+_22359919 Show fit	0.01	ENSDART00000009591	crygs4 NCBI UniProt ZFIN ENSEMBL Google Show fit	crystallin, gamma S4

Network of associatons between targets according to the STRING database.

First level regulatory network of prdm4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.2	0.9	GO:0035988	chondrocyte proliferation(GO:0035988)
0.1	0.2	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0036388	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0	0.0	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	0.8	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0047389	glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0	0.1	GO:0043142	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	0.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.8	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA