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PRJNA195909:zebrafish embryo and larva development

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Results for prdm14

Z-value: 0.55

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Transcription factors associated with prdm14

Gene Symbol Gene ID Gene Info
prdm14
ENSDARG00000045371 PR domain containing 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prdm14dr11_v1_chr24_+_14451404_14451404-0.068.7e-01Click!

Activity profile of prdm14 motif

Sorted Z-values of prdm14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_49069087 0.70 ENSDART00000150622
si:ch211-234c11.3
si:ch211-234c11.3
chr14_+_35428152 0.61 ENSDART00000172597
sytl4
synaptotagmin-like 4
chr20_+_51061695 0.58 ENSDART00000134416
im:7140055
im:7140055
chr3_-_25268751 0.50 ENSDART00000139423
mgat3a
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a
chr4_-_46648979 0.47 ENSDART00000162101
BX927193.2

chr23_+_9522942 0.47 ENSDART00000137751
osbpl2b
oxysterol binding protein-like 2b
chr5_-_67115872 0.46 ENSDART00000065262
rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr17_+_25871304 0.45 ENSDART00000185143
wapla
WAPL cohesin release factor a
chr7_+_34794829 0.45 ENSDART00000009698
ENSDART00000075089
ENSDART00000173456
esrp2
epithelial splicing regulatory protein 2
chr18_+_44768829 0.42 ENSDART00000016271
ilvbl
ilvB (bacterial acetolactate synthase)-like
chr23_+_9522781 0.42 ENSDART00000136486
osbpl2b
oxysterol binding protein-like 2b
chr17_+_12075805 0.42 ENSDART00000155329
cnsta
consortin, connexin sorting protein a
chr8_-_25566347 0.42 ENSDART00000138289
ENSDART00000078022
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr17_+_27162367 0.41 ENSDART00000193345
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr10_-_33343244 0.41 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr11_+_31380495 0.38 ENSDART00000185073
sipa1l2
signal-induced proliferation-associated 1 like 2
chr11_-_23080970 0.35 ENSDART00000127791
atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr5_+_37903790 0.34 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr24_+_26402110 0.33 ENSDART00000133684
si:ch211-230g15.5
si:ch211-230g15.5
chr12_-_6818676 0.32 ENSDART00000106391
pcdh15b
protocadherin-related 15b
chr8_-_49285801 0.32 ENSDART00000113159
prickle3
prickle homolog 3
chr6_-_24384654 0.32 ENSDART00000164723
brdt
bromodomain, testis-specific
chr13_+_49727333 0.31 ENSDART00000168799
ENSDART00000037559
ggps1
geranylgeranyl diphosphate synthase 1
chr6_+_518979 0.30 ENSDART00000151012
CACNA1I (1 of many)
si:ch73-379f7.5
chr10_+_573667 0.29 ENSDART00000110384
smad4a
SMAD family member 4a
chr21_-_27272657 0.29 ENSDART00000040754
ENSDART00000175009
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr15_-_34930727 0.28 ENSDART00000179723
dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr23_-_27442544 0.28 ENSDART00000019521
dip2ba
disco-interacting protein 2 homolog Ba
chr21_-_27273147 0.28 ENSDART00000143239
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr2_-_32826108 0.27 ENSDART00000098834
prpf4ba
pre-mRNA processing factor 4Ba
chr9_+_33261330 0.27 ENSDART00000135384
usp9
ubiquitin specific peptidase 9
chr21_-_14692119 0.25 ENSDART00000123047
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr23_+_21261313 0.25 ENSDART00000104268
ENSDART00000159046
emc1
ER membrane protein complex subunit 1
chr4_-_17353100 0.24 ENSDART00000134467
ENSDART00000189019
parpbp
PARP1 binding protein
chr2_-_37458527 0.24 ENSDART00000146820
si:dkey-57k2.7
si:dkey-57k2.7
chr11_-_18791834 0.24 ENSDART00000156431
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr19_-_4851411 0.23 ENSDART00000110398
fbxl20
F-box and leucine-rich repeat protein 20
chr10_-_32877348 0.23 ENSDART00000018977
ENSDART00000133421
rabgef1
RAB guanine nucleotide exchange factor (GEF) 1
chr7_+_13491452 0.21 ENSDART00000053535
arih1l
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 like
chr20_-_4049862 0.21 ENSDART00000158057
sprtn
SprT-like N-terminal domain
chr9_+_8364553 0.21 ENSDART00000190713
si:dkey-90l23.2
si:dkey-90l23.2
chr17_+_28675120 0.20 ENSDART00000159067
hectd1
HECT domain containing 1
chr5_-_69482891 0.19 ENSDART00000109487
CABZ01032476.1

chr2_+_32826235 0.18 ENSDART00000143127
si:dkey-154p10.3
si:dkey-154p10.3
chr7_+_51324834 0.17 ENSDART00000114429
usp12b
ubiquitin specific peptidase 12b
chr9_-_33477588 0.16 ENSDART00000144150
caska
calcium/calmodulin-dependent serine protein kinase a
chr16_+_32014552 0.14 ENSDART00000047570
mboat7
membrane bound O-acyltransferase domain containing 7
chr1_+_46509176 0.13 ENSDART00000166028
mcf2la
mcf.2 cell line derived transforming sequence-like a
chr13_+_18321140 0.13 ENSDART00000180947
eif4e1c
eukaryotic translation initiation factor 4E family member 1c
chr17_+_30843881 0.13 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr18_-_25646286 0.13 ENSDART00000099511
ENSDART00000186890
si:ch211-13k12.2
si:ch211-13k12.2
chr24_-_21131607 0.11 ENSDART00000010126
zdhhc23b
zinc finger, DHHC-type containing 23b
chr18_+_27926839 0.11 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr11_+_13642157 0.11 ENSDART00000060251
wdr18
WD repeat domain 18
chr2_-_36819624 0.11 ENSDART00000140844
slitrk3b
SLIT and NTRK-like family, member 3b
chr6_-_39919982 0.10 ENSDART00000065091
ENSDART00000064903
sumf1
sulfatase modifying factor 1
chr7_+_13418812 0.10 ENSDART00000191905
ENSDART00000091567
dagla
diacylglycerol lipase, alpha
chr1_+_27690 0.10 ENSDART00000162928
eed
embryonic ectoderm development
chr15_+_20363859 0.10 ENSDART00000166846
supt5h
SPT5 homolog, DSIF elongation factor subunit
chr22_+_39074688 0.08 ENSDART00000153547
ip6k1
inositol hexakisphosphate kinase 1
chr10_-_43721530 0.08 ENSDART00000025366
cetn3
centrin 3
chr22_+_16308806 0.08 ENSDART00000162685
lrrc39
leucine rich repeat containing 39
chr8_+_47677208 0.07 ENSDART00000123254
dpp9
dipeptidyl-peptidase 9
chr21_-_14630831 0.07 ENSDART00000132142
ENSDART00000089967
cacna1bb
calcium channel, voltage-dependent, N type, alpha 1B subunit, b
chr7_-_17780048 0.07 ENSDART00000183336
si:dkey-106g10.7
si:dkey-106g10.7
chr20_-_51727860 0.07 ENSDART00000147044
brox
BRO1 domain and CAAX motif containing
chr20_-_46467280 0.07 ENSDART00000060702
rmdn3
regulator of microtubule dynamics 3
chr7_+_16806473 0.07 ENSDART00000113332
ENSDART00000173541
nav2a
neuron navigator 2a
chr8_-_25716074 0.06 ENSDART00000007482
tspy
testis specific protein, Y-linked
chr24_-_30275735 0.05 ENSDART00000168723
snx7
sorting nexin 7
chr12_-_4435303 0.05 ENSDART00000159007
si:ch211-173d10.1
si:ch211-173d10.1
chr2_-_14793343 0.05 ENSDART00000132264
si:ch73-366i20.1
si:ch73-366i20.1
chr10_+_29849497 0.05 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr22_-_9890386 0.04 ENSDART00000132304
si:dkey-253d23.5
si:dkey-253d23.5
chr3_-_24456451 0.04 ENSDART00000024480
ENSDART00000156814
baiap2l2a
BAI1-associated protein 2-like 2a
chr25_-_8030113 0.04 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr9_-_40073255 0.03 ENSDART00000189139
IKZF2
si:zfos-1425h8.1
chr23_-_2448234 0.02 ENSDART00000082097
LO018513.1

chr24_-_22003031 0.02 ENSDART00000133627
si:rp71-1f1.5
si:rp71-1f1.5
chr21_+_44300689 0.02 ENSDART00000186298
ENSDART00000142810
gabra3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr22_+_2680895 0.01 ENSDART00000082245
zgc:194221
zgc:194221

Network of associatons between targets according to the STRING database.

First level regulatory network of prdm14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.4 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.3 GO:0051037 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 0.4 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.1 0.5 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.2 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.3 GO:1901985 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.3 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.0 0.1 GO:0060760 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.4 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005948 acetolactate synthase complex(GO:0005948)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003984 acetolactate synthase activity(GO:0003984)
0.1 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.9 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis